Tumor promotion by fecapentaene-12 in a rat colon carcinogenesis model

Fecapentaenes are a group of fecal mutagens produced by anaerobic microflora of the colon. The potential of fecapentaene-12 (FP-12) to promote tumor development was tested in a rat colon carcinogenesis model using N-methyl-N-nitrosourea (MNU) as the initiating agent. Two groups of female F-344 rats...

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Veröffentlicht in:	Carcinogenesis (New York) 1993-07, Vol.14 (7), p.1261-1264
Hauptverfasser:	Zarkovic, Mirjana, Qin, Xiusheng, Nakatsuru, Yoko, Oda, Hideaki, Nakamura, Takuro, Shamsuddin, Abulkalam M., Ishikawa, Takatoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinogens - toxicity Chemical agents Cocarcinogenesis Colonic Neoplasms - chemically induced Colonic Neoplasms - pathology Disease Models, Animal Female Intestinal Mucosa - drug effects Intestinal Mucosa - pathology Medical sciences Methylnitrosourea - toxicity Polyenes - toxicity Rats Rats, Inbred F344 Tumors
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