Tumor promotion by fecapentaene-12 in a rat colon carcinogenesis model
Fecapentaenes are a group of fecal mutagens produced by anaerobic microflora of the colon. The potential of fecapentaene-12 (FP-12) to promote tumor development was tested in a rat colon carcinogenesis model using N-methyl-N-nitrosourea (MNU) as the initiating agent. Two groups of female F-344 rats...
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Veröffentlicht in: | Carcinogenesis (New York) 1993-07, Vol.14 (7), p.1261-1264 |
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creator | Zarkovic, Mirjana Qin, Xiusheng Nakatsuru, Yoko Oda, Hideaki Nakamura, Takuro Shamsuddin, Abulkalam M. Ishikawa, Takatoshi |
description | Fecapentaenes are a group of fecal mutagens produced by anaerobic microflora of the colon. The potential of fecapentaene-12 (FP-12) to promote tumor development was tested in a rat colon carcinogenesis model using N-methyl-N-nitrosourea (MNU) as the initiating agent. Two groups of female F-344 rats were initiated by intrarectal instillations of MNU (2 mg in 0.5 ml H2O, 3 times a week, for 3 weeks; MNU and MNU + FP-12 groups). Two additional groups (FP-12 and Control) were given H2O without carcinogen. In the post-initiation phase, rats of the MNU + FP-12 and FP-12 groups were intrarectally administered 400 ng of FP-12 in 0.5 ml T-E buffer, twice a week, for 24 weeks, whereas the MNU and Control groups received the vehicle only. Tumors were found only in the MNU and MNU + FP-12 groups, their number being higher in the latter. The number of carcinoma bearing rats as well as the average number of carcinomas per rat were significantly higher (P< 0.05) in the MNU + FP-12 group as compared to the MNU-alone values. Aberrant crypt foci (ACF) were found in all carcinogen-treated rats, including those that did not contain tumors, whereas none were observed in the FP-12 and Control groups. The average number of ACF/cm2 was also significantly higher in the MNU + FP-12 group, as was the case for the average number of ACF containing >10 aberrant crypts per focus. These findings suggest that FP-12 can express promoting activity in chemically induced colon carcinogenesis. |
doi_str_mv | 10.1093/carcin/14.7.1261 |
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The potential of fecapentaene-12 (FP-12) to promote tumor development was tested in a rat colon carcinogenesis model using N-methyl-N-nitrosourea (MNU) as the initiating agent. Two groups of female F-344 rats were initiated by intrarectal instillations of MNU (2 mg in 0.5 ml H2O, 3 times a week, for 3 weeks; MNU and MNU + FP-12 groups). Two additional groups (FP-12 and Control) were given H2O without carcinogen. In the post-initiation phase, rats of the MNU + FP-12 and FP-12 groups were intrarectally administered 400 ng of FP-12 in 0.5 ml T-E buffer, twice a week, for 24 weeks, whereas the MNU and Control groups received the vehicle only. Tumors were found only in the MNU and MNU + FP-12 groups, their number being higher in the latter. The number of carcinoma bearing rats as well as the average number of carcinomas per rat were significantly higher (P< 0.05) in the MNU + FP-12 group as compared to the MNU-alone values. Aberrant crypt foci (ACF) were found in all carcinogen-treated rats, including those that did not contain tumors, whereas none were observed in the FP-12 and Control groups. The average number of ACF/cm2 was also significantly higher in the MNU + FP-12 group, as was the case for the average number of ACF containing >10 aberrant crypts per focus. These findings suggest that FP-12 can express promoting activity in chemically induced colon carcinogenesis.</description><identifier>ISSN: 0143-3334</identifier><identifier>EISSN: 1460-2180</identifier><identifier>DOI: 10.1093/carcin/14.7.1261</identifier><identifier>PMID: 8330337</identifier><identifier>CODEN: CRNGDP</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Carcinogens - toxicity ; Chemical agents ; Cocarcinogenesis ; Colonic Neoplasms - chemically induced ; Colonic Neoplasms - pathology ; Disease Models, Animal ; Female ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - pathology ; Medical sciences ; Methylnitrosourea - toxicity ; Polyenes - toxicity ; Rats ; Rats, Inbred F344 ; Tumors</subject><ispartof>Carcinogenesis (New York), 1993-07, Vol.14 (7), p.1261-1264</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-e2c158438af28c14c64d480e905bd44df7b2fb60ceb78a5121957c86816dec3e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4848694$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8330337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zarkovic, Mirjana</creatorcontrib><creatorcontrib>Qin, Xiusheng</creatorcontrib><creatorcontrib>Nakatsuru, Yoko</creatorcontrib><creatorcontrib>Oda, Hideaki</creatorcontrib><creatorcontrib>Nakamura, Takuro</creatorcontrib><creatorcontrib>Shamsuddin, Abulkalam M.</creatorcontrib><creatorcontrib>Ishikawa, Takatoshi</creatorcontrib><title>Tumor promotion by fecapentaene-12 in a rat colon carcinogenesis model</title><title>Carcinogenesis (New York)</title><addtitle>Carcinogenesis</addtitle><description>Fecapentaenes are a group of fecal mutagens produced by anaerobic microflora of the colon. The potential of fecapentaene-12 (FP-12) to promote tumor development was tested in a rat colon carcinogenesis model using N-methyl-N-nitrosourea (MNU) as the initiating agent. Two groups of female F-344 rats were initiated by intrarectal instillations of MNU (2 mg in 0.5 ml H2O, 3 times a week, for 3 weeks; MNU and MNU + FP-12 groups). Two additional groups (FP-12 and Control) were given H2O without carcinogen. In the post-initiation phase, rats of the MNU + FP-12 and FP-12 groups were intrarectally administered 400 ng of FP-12 in 0.5 ml T-E buffer, twice a week, for 24 weeks, whereas the MNU and Control groups received the vehicle only. Tumors were found only in the MNU and MNU + FP-12 groups, their number being higher in the latter. The number of carcinoma bearing rats as well as the average number of carcinomas per rat were significantly higher (P< 0.05) in the MNU + FP-12 group as compared to the MNU-alone values. Aberrant crypt foci (ACF) were found in all carcinogen-treated rats, including those that did not contain tumors, whereas none were observed in the FP-12 and Control groups. The average number of ACF/cm2 was also significantly higher in the MNU + FP-12 group, as was the case for the average number of ACF containing >10 aberrant crypts per focus. These findings suggest that FP-12 can express promoting activity in chemically induced colon carcinogenesis.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Carcinogens - toxicity</subject><subject>Chemical agents</subject><subject>Cocarcinogenesis</subject><subject>Colonic Neoplasms - chemically induced</subject><subject>Colonic Neoplasms - pathology</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Intestinal Mucosa - pathology</subject><subject>Medical sciences</subject><subject>Methylnitrosourea - toxicity</subject><subject>Polyenes - toxicity</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Tumors</subject><issn>0143-3334</issn><issn>1460-2180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1LxDAQxYMoun7cvQg9iLeumWaapEfxa4UVLyriJaTpVKptsyZd0P_eSpc9zeH93puZx9gp8DnwQlw6G1zTXwLO1RwyCTtsBih5moHmu2zGAUUqhMADdhjjJ-cgRV7ss30tBBdCzdjd87rzIVkF3_mh8X1S_iY1ObuifrDUUwpZ0vSJTYIdEufbkZh2-o9RjU1MOl9Re8z2attGOtnMI_Zyd_t8vUiXT_cP11fL1GGuh5QyB7lGoW2daQfoJFaoORU8LyvEqlZlVpeSOyqVtjlkUOTKaalBVuQEiSN2MeWOB3-vKQ6ma6KjtrU9-XU0IBVihsUI8gl0wccYqDar0HQ2_Brg5r86M71hAI0y_9WNlrNN9rrsqNoaNl2N-vlGt9HZtg62d03cYqhRywJHLJ2wJg70s5Vt-DJSCZWbxdu7Ua9KLB5vlmYh_gArS4Z0</recordid><startdate>19930701</startdate><enddate>19930701</enddate><creator>Zarkovic, Mirjana</creator><creator>Qin, Xiusheng</creator><creator>Nakatsuru, Yoko</creator><creator>Oda, Hideaki</creator><creator>Nakamura, Takuro</creator><creator>Shamsuddin, Abulkalam M.</creator><creator>Ishikawa, Takatoshi</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19930701</creationdate><title>Tumor promotion by fecapentaene-12 in a rat colon carcinogenesis model</title><author>Zarkovic, Mirjana ; Qin, Xiusheng ; Nakatsuru, Yoko ; Oda, Hideaki ; Nakamura, Takuro ; Shamsuddin, Abulkalam M. ; Ishikawa, Takatoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-e2c158438af28c14c64d480e905bd44df7b2fb60ceb78a5121957c86816dec3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Carcinogens - toxicity</topic><topic>Chemical agents</topic><topic>Cocarcinogenesis</topic><topic>Colonic Neoplasms - chemically induced</topic><topic>Colonic Neoplasms - pathology</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Intestinal Mucosa - pathology</topic><topic>Medical sciences</topic><topic>Methylnitrosourea - toxicity</topic><topic>Polyenes - toxicity</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zarkovic, Mirjana</creatorcontrib><creatorcontrib>Qin, Xiusheng</creatorcontrib><creatorcontrib>Nakatsuru, Yoko</creatorcontrib><creatorcontrib>Oda, Hideaki</creatorcontrib><creatorcontrib>Nakamura, Takuro</creatorcontrib><creatorcontrib>Shamsuddin, Abulkalam M.</creatorcontrib><creatorcontrib>Ishikawa, Takatoshi</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Carcinogenesis (New York)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zarkovic, Mirjana</au><au>Qin, Xiusheng</au><au>Nakatsuru, Yoko</au><au>Oda, Hideaki</au><au>Nakamura, Takuro</au><au>Shamsuddin, Abulkalam M.</au><au>Ishikawa, Takatoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor promotion by fecapentaene-12 in a rat colon carcinogenesis model</atitle><jtitle>Carcinogenesis (New York)</jtitle><addtitle>Carcinogenesis</addtitle><date>1993-07-01</date><risdate>1993</risdate><volume>14</volume><issue>7</issue><spage>1261</spage><epage>1264</epage><pages>1261-1264</pages><issn>0143-3334</issn><eissn>1460-2180</eissn><coden>CRNGDP</coden><abstract>Fecapentaenes are a group of fecal mutagens produced by anaerobic microflora of the colon. The potential of fecapentaene-12 (FP-12) to promote tumor development was tested in a rat colon carcinogenesis model using N-methyl-N-nitrosourea (MNU) as the initiating agent. Two groups of female F-344 rats were initiated by intrarectal instillations of MNU (2 mg in 0.5 ml H2O, 3 times a week, for 3 weeks; MNU and MNU + FP-12 groups). Two additional groups (FP-12 and Control) were given H2O without carcinogen. In the post-initiation phase, rats of the MNU + FP-12 and FP-12 groups were intrarectally administered 400 ng of FP-12 in 0.5 ml T-E buffer, twice a week, for 24 weeks, whereas the MNU and Control groups received the vehicle only. Tumors were found only in the MNU and MNU + FP-12 groups, their number being higher in the latter. The number of carcinoma bearing rats as well as the average number of carcinomas per rat were significantly higher (P< 0.05) in the MNU + FP-12 group as compared to the MNU-alone values. Aberrant crypt foci (ACF) were found in all carcinogen-treated rats, including those that did not contain tumors, whereas none were observed in the FP-12 and Control groups. The average number of ACF/cm2 was also significantly higher in the MNU + FP-12 group, as was the case for the average number of ACF containing >10 aberrant crypts per focus. These findings suggest that FP-12 can express promoting activity in chemically induced colon carcinogenesis.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>8330337</pmid><doi>10.1093/carcin/14.7.1261</doi><tpages>4</tpages></addata></record> |
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subjects | Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinogens - toxicity Chemical agents Cocarcinogenesis Colonic Neoplasms - chemically induced Colonic Neoplasms - pathology Disease Models, Animal Female Intestinal Mucosa - drug effects Intestinal Mucosa - pathology Medical sciences Methylnitrosourea - toxicity Polyenes - toxicity Rats Rats, Inbred F344 Tumors |
title | Tumor promotion by fecapentaene-12 in a rat colon carcinogenesis model |
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