Production of hydrogen peroxide by neutrophilic polymorphonuclear leukocytes in patients with diabetic nephropathy
The production of hydrogen peroxide (H2O2) by neutrophilic polymorphonuclear leukocytes (PMN) after stimulation with phorbol myristate acetate (PMA), n‐formyl‐I‐methionyl‐IIeucyl‐I‐phenylalanine (FMLP), aggregated human IgG, or Staphylococcus aureus was determined in 36 patients with non‐insulin dep...
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| Veröffentlicht in: | Journal of clinical laboratory analysis 1993, Vol.7 (4), p.209-213 |
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| creator | Watanabe, Asako Tomino, Yasuhiko Yokoyama, Ken-Ichi Koide, Hikaru |
| description | The production of hydrogen peroxide (H2O2) by neutrophilic polymorphonuclear leukocytes (PMN) after stimulation with phorbol myristate acetate (PMA), n‐formyl‐I‐methionyl‐IIeucyl‐I‐phenylalanine (FMLP), aggregated human IgG, or Staphylococcus aureus was determined in 36 patients with non‐insulin dependent diabetes mellitus (NIDDM). H2O2 production by PMN after stimulation was measured using flow cytometry. Thirty‐six patients with NIDDM were divided into four stages as follows: 1) stage I: non‐microalbuminuric stage;2) stage II: microalbuminuric stage; 3) stage III: proteinuric stage without impairment of renal function; and 4) stage IV: proteinuric stage with impairment of renal function. H2O2 production after PMA stimulation in all stages of NIDDM patients was higher than that in healthy controls. This increase of H2O2 production by PMN was particularly observed in stage IV of NIDDM patients after stimulation. Furthermore, H2O2 production in patients in stage IV was higher than that in patients with non‐diabetic disease with impairment of renal function.
It appears that reactive oxygen species produced by PMN after stimulation under some conditions may play an important role in the progression of diabetic nephropathy. © 1993 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jcla.1860070404 |
| format | Article |
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It appears that reactive oxygen species produced by PMN after stimulation under some conditions may play an important role in the progression of diabetic nephropathy. © 1993 Wiley‐Liss, Inc.</description><identifier>ISSN: 0887-8013</identifier><identifier>EISSN: 1098-2825</identifier><identifier>DOI: 10.1002/jcla.1860070404</identifier><identifier>PMID: 8360796</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Blood Glucose - analysis ; Diabetes Mellitus, Type 2 - blood ; Diabetic Nephropathies - blood ; Female ; flow cytometry ; Humans ; Hydrogen Peroxide - blood ; Immunoglobulin G - immunology ; Male ; Middle Aged ; N-Formylmethionine Leucyl-Phenylalanine - pharmacology ; Neutrophils - metabolism ; NIDDM ; reactive oxygen species ; Staphylococcus aureus - immunology ; Tetradecanoylphorbol Acetate - pharmacology</subject><ispartof>Journal of clinical laboratory analysis, 1993, Vol.7 (4), p.209-213</ispartof><rights>Copyright © 1993 Wiley Periodicals, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4134-d96ff81e536598e5f0a3d30ec953c6ea9d080ca733af74e3c0a10712ea349e753</citedby><cites>FETCH-LOGICAL-c4134-d96ff81e536598e5f0a3d30ec953c6ea9d080ca733af74e3c0a10712ea349e753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcla.1860070404$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcla.1860070404$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,4025,27927,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8360796$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Watanabe, Asako</creatorcontrib><creatorcontrib>Tomino, Yasuhiko</creatorcontrib><creatorcontrib>Yokoyama, Ken-Ichi</creatorcontrib><creatorcontrib>Koide, Hikaru</creatorcontrib><title>Production of hydrogen peroxide by neutrophilic polymorphonuclear leukocytes in patients with diabetic nephropathy</title><title>Journal of clinical laboratory analysis</title><addtitle>J. Clin. Lab. Anal</addtitle><description>The production of hydrogen peroxide (H2O2) by neutrophilic polymorphonuclear leukocytes (PMN) after stimulation with phorbol myristate acetate (PMA), n‐formyl‐I‐methionyl‐IIeucyl‐I‐phenylalanine (FMLP), aggregated human IgG, or Staphylococcus aureus was determined in 36 patients with non‐insulin dependent diabetes mellitus (NIDDM). H2O2 production by PMN after stimulation was measured using flow cytometry. Thirty‐six patients with NIDDM were divided into four stages as follows: 1) stage I: non‐microalbuminuric stage;2) stage II: microalbuminuric stage; 3) stage III: proteinuric stage without impairment of renal function; and 4) stage IV: proteinuric stage with impairment of renal function. H2O2 production after PMA stimulation in all stages of NIDDM patients was higher than that in healthy controls. This increase of H2O2 production by PMN was particularly observed in stage IV of NIDDM patients after stimulation. Furthermore, H2O2 production in patients in stage IV was higher than that in patients with non‐diabetic disease with impairment of renal function.
It appears that reactive oxygen species produced by PMN after stimulation under some conditions may play an important role in the progression of diabetic nephropathy. © 1993 Wiley‐Liss, Inc.</description><subject>Blood Glucose - analysis</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetic Nephropathies - blood</subject><subject>Female</subject><subject>flow cytometry</subject><subject>Humans</subject><subject>Hydrogen Peroxide - blood</subject><subject>Immunoglobulin G - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>N-Formylmethionine Leucyl-Phenylalanine - pharmacology</subject><subject>Neutrophils - metabolism</subject><subject>NIDDM</subject><subject>reactive oxygen species</subject><subject>Staphylococcus aureus - immunology</subject><subject>Tetradecanoylphorbol Acetate - pharmacology</subject><issn>0887-8013</issn><issn>1098-2825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLFv1DAUhy1EVY7CzITkiS3t8zmxHTFVR1tanQpIICQWy-e8ELe-ONiO2vz35HSnVkxMb3i_7xs-Qt4xOGUAy7M7680pUwJAQgnlC7JgUKtiqZbVS7IApWShgPFX5HVKdwCgaiaOybHiAmQtFiR-jaEZbXahp6Gl3dTE8Bt7OmAMj65Buploj2OOYeicd5YOwU_bEIcu9KP1aCL1ON4HO2VM1M2gyQ77nOiDyx1tnNlgnrEeh252mNxNb8hRa3zCt4d7Qn5cXnxffS7WX66uV-frwpaMl0VTi7ZVDCsuqlph1YLhDQe0dcWtQFM3oMAayblpZYncgmEg2RINL2uUFT8hH_beIYY_I6asty5Z9N70GMakmZDlPN0Nz_ZDG0NKEVs9RLc1cdIM9K6y3lXWz5Vn4v1BPW622DztD1nn_8f9_8F5nP6n0zer9fk_9mJPu5Tx8Yk28V4LyWWlf95eafXpm2I365X-xf8CgVacSQ</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Watanabe, Asako</creator><creator>Tomino, Yasuhiko</creator><creator>Yokoyama, Ken-Ichi</creator><creator>Koide, Hikaru</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>1993</creationdate><title>Production of hydrogen peroxide by neutrophilic polymorphonuclear leukocytes in patients with diabetic nephropathy</title><author>Watanabe, Asako ; Tomino, Yasuhiko ; Yokoyama, Ken-Ichi ; Koide, Hikaru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4134-d96ff81e536598e5f0a3d30ec953c6ea9d080ca733af74e3c0a10712ea349e753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Blood Glucose - analysis</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetic Nephropathies - blood</topic><topic>Female</topic><topic>flow cytometry</topic><topic>Humans</topic><topic>Hydrogen Peroxide - blood</topic><topic>Immunoglobulin G - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>N-Formylmethionine Leucyl-Phenylalanine - pharmacology</topic><topic>Neutrophils - metabolism</topic><topic>NIDDM</topic><topic>reactive oxygen species</topic><topic>Staphylococcus aureus - immunology</topic><topic>Tetradecanoylphorbol Acetate - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Watanabe, Asako</creatorcontrib><creatorcontrib>Tomino, Yasuhiko</creatorcontrib><creatorcontrib>Yokoyama, Ken-Ichi</creatorcontrib><creatorcontrib>Koide, Hikaru</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of clinical laboratory analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Watanabe, Asako</au><au>Tomino, Yasuhiko</au><au>Yokoyama, Ken-Ichi</au><au>Koide, Hikaru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Production of hydrogen peroxide by neutrophilic polymorphonuclear leukocytes in patients with diabetic nephropathy</atitle><jtitle>Journal of clinical laboratory analysis</jtitle><addtitle>J. Clin. Lab. Anal</addtitle><date>1993</date><risdate>1993</risdate><volume>7</volume><issue>4</issue><spage>209</spage><epage>213</epage><pages>209-213</pages><issn>0887-8013</issn><eissn>1098-2825</eissn><abstract>The production of hydrogen peroxide (H2O2) by neutrophilic polymorphonuclear leukocytes (PMN) after stimulation with phorbol myristate acetate (PMA), n‐formyl‐I‐methionyl‐IIeucyl‐I‐phenylalanine (FMLP), aggregated human IgG, or Staphylococcus aureus was determined in 36 patients with non‐insulin dependent diabetes mellitus (NIDDM). H2O2 production by PMN after stimulation was measured using flow cytometry. Thirty‐six patients with NIDDM were divided into four stages as follows: 1) stage I: non‐microalbuminuric stage;2) stage II: microalbuminuric stage; 3) stage III: proteinuric stage without impairment of renal function; and 4) stage IV: proteinuric stage with impairment of renal function. H2O2 production after PMA stimulation in all stages of NIDDM patients was higher than that in healthy controls. This increase of H2O2 production by PMN was particularly observed in stage IV of NIDDM patients after stimulation. Furthermore, H2O2 production in patients in stage IV was higher than that in patients with non‐diabetic disease with impairment of renal function.
It appears that reactive oxygen species produced by PMN after stimulation under some conditions may play an important role in the progression of diabetic nephropathy. © 1993 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8360796</pmid><doi>10.1002/jcla.1860070404</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals |
| subjects | Blood Glucose - analysis Diabetes Mellitus, Type 2 - blood Diabetic Nephropathies - blood Female flow cytometry Humans Hydrogen Peroxide - blood Immunoglobulin G - immunology Male Middle Aged N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neutrophils - metabolism NIDDM reactive oxygen species Staphylococcus aureus - immunology Tetradecanoylphorbol Acetate - pharmacology |
| title | Production of hydrogen peroxide by neutrophilic polymorphonuclear leukocytes in patients with diabetic nephropathy |
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