Reduction of liver taurine in rats by β-alanine treatment increases carbon tetrachloride toxicity

Treatment of rats with β-alanine increases the urinary levels and markedly reduces the concentration of taurine in the liver. Dosing with carbon tetrachloride (CCL 4) during treatment with β-alanine results in a marked decrease in urinary taurine concomitant with a decrease in food intake. Treatment...

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Veröffentlicht in:	Toxicology (Amsterdam) 1993-01, Vol.77 (1), p.7-20
Hauptverfasser:	Waterfield, Catherine J., Turton, John A., Scales, M.David C., Timbrell, John A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Animals Aspartate Aminotransferases - blood beta-Alanine - pharmacology Biological and medical sciences Carbon tetrachloride Carbon Tetrachloride - administration & dosage Carbon Tetrachloride - toxicity Creatine - urine Eating General pharmacology Hepatotoxicity Increased susceptibility Liver Liver - chemistry Liver - drug effects Male Medical sciences Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Taurine Taurine - analysis Taurine - urine Triglycerides - analysis β-Alanine
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