Cloning, Sequence Determination, and Regulation of the Ribonucleotide Reductase Subunits from Plasmodium falciparum: A Target for Antimalarial Therapy

Malaria remains a leading cause of morbidity and mortality worldwide, accounting for more than one million deaths annually. We have focused on the reduction of ribonucleotides to 2'-deoxyribonucleotides, catalyzed by ribonucleotide reductase, which represents the rate-determining step in DNA re...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-10, Vol.90 (20), p.9280-9284
Hauptverfasser:	Rubin, Harvey, Salem, Jerome S., Li, Lin-Sheng, Yang, Fu-de, Mama, Saffudin, Wang, Zhi-mei, Fisher, Alison, Hamann, Christian S., Cooperman, Barry S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarials Antiparasitic agents Base Sequence Binding Sites Biological and medical sciences Cell Cycle Chromosome Mapping Chromosomes Cloning, Molecular Deoxyribonucleic acid DNA DNA Primers - genetics Enzymes Escherichia coli - genetics Gene Expression Generally accepted auditing standards Genes Genes, Protozoan Humans Inhibitory concentration 50 Iron - metabolism Malaria Medical research Medical sciences Molecular Sequence Data Pharmacology. Drug treatments Plasmodium falciparum Plasmodium falciparum - enzymology Plasmodium falciparum - genetics Polymerase chain reaction Ribonucleotide Reductases - genetics Ribonucleotides RNA, Messenger - genetics Sequence Alignment Sequence Homology, Amino Acid Therapy
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