Endogenous gamma interferon mediates resistance to Brucella abortus infection
Depletion of endogenous gamma interferon (IFN-gamma) with anti-IFN-gamma monoclonal antibody resulted in increased numbers of Brucella abortus in the spleen and liver of infected CBA mice. This increase was accompanied by a decrease in splenomegaly and a lower proportion of macrophages in the spleen...
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| Veröffentlicht in: | Infection and Immunity 1993-11, Vol.61 (11), p.4899-4901 |
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| container_title | Infection and Immunity |
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| creator | Zhan, Y Cheers, C |
| description | Depletion of endogenous gamma interferon (IFN-gamma) with anti-IFN-gamma monoclonal antibody resulted in increased numbers of Brucella abortus in the spleen and liver of infected CBA mice. This increase was accompanied by a decrease in splenomegaly and a lower proportion of macrophages in the spleen. Furthermore, treatment of recipient mice with anti-IFN-gamma antibody blocked the adoptive transfer of resistance with immune T cells. Together, the results indicated that endogenous IFN-gamma plays an important role in mediating resistance to primary and secondary Brucella infection |
| doi_str_mv | 10.1128/iai.61.11.4899-4901.1993 |
| format | Article |
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This increase was accompanied by a decrease in splenomegaly and a lower proportion of macrophages in the spleen. Furthermore, treatment of recipient mice with anti-IFN-gamma antibody blocked the adoptive transfer of resistance with immune T cells. Together, the results indicated that endogenous IFN-gamma plays an important role in mediating resistance to primary and secondary Brucella infection</description><subject>Animals</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>BRUCELLA ABORTUS</subject><subject>Brucellosis - immunology</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Immunity, Innate</topic><topic>Immunotherapy, Adoptive</topic><topic>INTERFERON</topic><topic>Interferon-gamma - physiology</topic><topic>INTERFERONAS</topic><topic>Mice</topic><topic>Mice, Inbred CBA</topic><topic>Microbiology</topic><topic>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</topic><topic>RATON</topic><topic>SOURIS</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhan, Y</creatorcontrib><creatorcontrib>Cheers, C</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Infection and Immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhan, Y</au><au>Cheers, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endogenous gamma interferon mediates resistance to Brucella abortus infection</atitle><jtitle>Infection and Immunity</jtitle><addtitle>Infect Immun</addtitle><date>1993-11-01</date><risdate>1993</risdate><volume>61</volume><issue>11</issue><spage>4899</spage><epage>4901</epage><pages>4899-4901</pages><issn>0019-9567</issn><eissn>1098-5522</eissn><coden>INFIBR</coden><abstract>Depletion of endogenous gamma interferon (IFN-gamma) with anti-IFN-gamma monoclonal antibody resulted in increased numbers of Brucella abortus in the spleen and liver of infected CBA mice. This increase was accompanied by a decrease in splenomegaly and a lower proportion of macrophages in the spleen. Furthermore, treatment of recipient mice with anti-IFN-gamma antibody blocked the adoptive transfer of resistance with immune T cells. Together, the results indicated that endogenous IFN-gamma plays an important role in mediating resistance to primary and secondary Brucella infection</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>8406893</pmid><doi>10.1128/iai.61.11.4899-4901.1993</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Infection and Immunity, 1993-11, Vol.61 (11), p.4899-4901 |
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| language | eng |
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| source | American Society for Microbiology; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Antibodies, Monoclonal - immunology Bacteriology Biological and medical sciences BRUCELLA ABORTUS Brucellosis - immunology Fundamental and applied biological sciences. Psychology Immunity, Innate Immunotherapy, Adoptive INTERFERON Interferon-gamma - physiology INTERFERONAS Mice Mice, Inbred CBA Microbiology Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains RATON SOURIS T-Lymphocytes - immunology |
| title | Endogenous gamma interferon mediates resistance to Brucella abortus infection |
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