Suppression of Autophagy Dysregulates the Antioxidant Response and Causes Premature Senescence of Melanocytes

Autophagy is the central cellular mechanism for delivering organelles and cytoplasm to lysosomes for degradation and recycling of their molecular components. To determine the contribution of autophagy to melanocyte (MC) biology, we inactivated the essential autophagy gene Atg7 specifically in MCs us...

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Veröffentlicht in:	Journal of investigative dermatology 2015-05, Vol.135 (5), p.1348-1357
Hauptverfasser:	Zhang, Cheng-Feng, Gruber, Florian, Ni, Chunya, Mildner, Michael, Koenig, Ulrich, Karner, Susanne, Barresi, Caterina, Rossiter, Heidemarie, Narzt, Marie-Sophie, Nagelreiter, Ionela M., Larue, Lionel, Tobin, Desmond J., Eckhart, Leopold, Tschachler, Erwin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging, Premature - metabolism Aging, Premature - physiopathology Animals Antioxidants - metabolism Autophagy - physiology Autophagy-Related Protein 7 Cell Proliferation - physiology Cells, Cultured Cellular Senescence - physiology Homeostasis - physiology Humans In Vitro Techniques Lipid Peroxidation - physiology Melanins - metabolism Melanocytes - metabolism Melanocytes - pathology Mice Mice, Knockout Microtubule-Associated Proteins - deficiency Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Models, Animal NF-E2-Related Factor 2 - metabolism Reactive Oxygen Species - metabolism
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