Obatoclax induces Beclin 1- and ATG5-dependent apoptosis and autophagy in adenoid cystic carcinoma cells

Objectives Adenoid cystic carcinoma (ACC) is one of the most common salivary gland cancers. The prognosis of adenoid cystic carcinoma is poor for its high frequency of distant metastases and insensitivity to chemotherapy or molecular therapies. This study investigated the effect of Obatoclax on aden...

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Veröffentlicht in:	Oral diseases 2015-05, Vol.21 (4), p.470-477
Hauptverfasser:	Liang, L-Z, Ma, B, Liang, Y-J, Liu, H-C, Zhang, T-H, Zheng, G-S, Su, Y-X, Liao, G-Q
Format:	Artikel
Sprache:	eng
Schlagworte:	adenoid cystic carcinoma Apoptosis ATG5 Autophagy Autophagy - drug effects Autophagy - genetics Autophagy-Related Protein 5 - antagonists & inhibitors Autophagy-Related Protein 5 - genetics Autophagy-Related Protein 5 - metabolism beclin 1 Beclin-1 - antagonists & inhibitors Beclin-1 - genetics Beclin-1 - metabolism Cancer Carcinoma, Adenoid Cystic - drug therapy Carcinoma, Adenoid Cystic - genetics Carcinoma, Adenoid Cystic - metabolism Carcinoma, Adenoid Cystic - pathology Cell Line, Tumor Cell Survival - drug effects Chemotherapy Dentistry Humans Prognosis Pyrroles - pharmacology Salivary Gland Neoplasms - drug therapy Salivary Gland Neoplasms - metabolism Salivary Gland Neoplasms - pathology
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