Divergent Construction of Pyrazoles via Michael Addition of N‑Arylhydrazones to 1,2-Diaza-1,3-dienes
The base (NaH)-promoted Michael addition of N-arylhydrazones (AHs) with 1,2-diaza-1,3-dienes (DDs) produces unprecedented β-azohydrazone adducts. Strategically, the use of AHs as acyl anion equivalents (d 1 synthon) and DDs as α-electrophiles (a 2 synthon) of carbonyl compounds open the way to two i...
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| Veröffentlicht in: | Organic letters 2015-04, Vol.17 (8), p.2014-2017 |
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| container_end_page | 2017 |
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| container_issue | 8 |
| container_start_page | 2014 |
| container_title | Organic letters |
| container_volume | 17 |
| creator | Mantenuto, Serena Mantellini, Fabio Favi, Gianfranco Attanasi, Orazio A |
| description | The base (NaH)-promoted Michael addition of N-arylhydrazones (AHs) with 1,2-diaza-1,3-dienes (DDs) produces unprecedented β-azohydrazone adducts. Strategically, the use of AHs as acyl anion equivalents (d 1 synthon) and DDs as α-electrophiles (a 2 synthon) of carbonyl compounds open the way to two important classes of pyrazole compounds. |
| doi_str_mv | 10.1021/acs.orglett.5b00776 |
| format | Article |
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| ispartof | Organic letters, 2015-04, Vol.17 (8), p.2014-2017 |
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| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Alkadienes - chemistry Aza Compounds - chemistry Hydrazones - chemistry Molecular Structure Pyrazoles - chemical synthesis Pyrazoles - chemistry |
| title | Divergent Construction of Pyrazoles via Michael Addition of N‑Arylhydrazones to 1,2-Diaza-1,3-dienes |
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