Higher lifetime chance of spontaneous surface antigen loss in hepatitis B carriers with genotype C infection
Summary Background Clearance of hepatitis B surface antigen (HBsAg) indicates clinical control of hepatitis B virus (HBV) infection. However, little is known about the impact of viral genomic variations on HBsAg loss. Methods We explored the association between viral genomic factors and HBsAg loss i...
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| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2015-05, Vol.41 (10), p.949-960 |
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| creator | Tseng, T.‐C. Liu, C.‐J. Chen, C.‐L. Yang, W.‐T. Yang, H.‐C. Su, T.‐H. Wang, C.‐C. Kuo, S. F.‐T. Liu, C.‐H. Chen, P.‐J. Chen, D.‐S. Kao, J.‐H. |
| description | Summary
Background
Clearance of hepatitis B surface antigen (HBsAg) indicates clinical control of hepatitis B virus (HBV) infection. However, little is known about the impact of viral genomic variations on HBsAg loss.
Methods
We explored the association between viral genomic factors and HBsAg loss in 2121HBeAg‐negative patients. HBV pre‐core stop codon (1896) and basal core promoter (BCP) (1762/1764) sequences were determined in patients with HBV DNA ≥200 IU/mL (N = 1693). The effect of HBV genotype on HBsAg loss was further validated in the whole cohort of 3445 HBsAg carriers.
Results
The cumulative lifetime (age 28–75 years) incidence of HBsAg loss was 50.4% in 2121 HBeAg‐negative patients. We found that genotype C, but not pre‐core stop codon or BCP mutants, was associated with HBsAg loss. Compared to genotype B patients, genotype C patients had higher lifetime chance of HBsAg loss, with hazard ratio of 1.8 (95% confidence interval: 1.4–2.4). Multivariable analysis showed that male sex, elevated ALT levels, lower serum HBV DNA and HBsAg levels, and genotype C infection were associated with higher chance of HBsAg loss independently. We then performed sensitivity analysis, which re‐included HBeAg‐positive, cirrhotic and treatment‐experienced patients, and confirmed the robustness of our results in 3445 HBsAg carriers.
Conclusion
Genotype C infection, compared to genotype B, is associated with a higher lifetime chance of HBsAg loss in Asian HBV carriers. |
| doi_str_mv | 10.1111/apt.13170 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1674199380</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1674199380</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3600-6289a56dc64889eca879614c6718021155cb88f3bd75b6e4675016e91c91ac923</originalsourceid><addsrcrecordid>eNp1kE1LAzEQQIMotlYP_gHJUQ_bJvuRTY5a1AoFPdRzyKaz3ch-mWQp_fdGt3pzLgPD48E8hK4pmdMwC9X7OU1oTk7QlCYsi2KSsFM0JTETUcxpMkEXzn0QQlhO4nM0iTNORJaSKapXZleBxbUpwZsGsK5UqwF3JXZ913rVQjc47AZbqnBWrTc7aHHdOYdNiyvolTfeOPyAtbLWgHV4b3yFA9X5Qw94GbgStDdde4nOSlU7uDruGXp_etwsV9H69flleb-OdMIIiVjMhcrYVrOUcwFa8VwwmmqWU05iSrNMF5yXSbHNs4JByvKMUAaCakGVFnEyQ7ejt7fd5wDOy8Y4DXU9fiMpy1MqRMJJQO9GVNvwkoVS9tY0yh4kJfI7rgxx5U_cwN4ctUPRwPaP_K0ZgMUI7E0Nh_9N8v5tMyq_ABhig2U</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1674199380</pqid></control><display><type>article</type><title>Higher lifetime chance of spontaneous surface antigen loss in hepatitis B carriers with genotype C infection</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Tseng, T.‐C. ; Liu, C.‐J. ; Chen, C.‐L. ; Yang, W.‐T. ; Yang, H.‐C. ; Su, T.‐H. ; Wang, C.‐C. ; Kuo, S. F.‐T. ; Liu, C.‐H. ; Chen, P.‐J. ; Chen, D.‐S. ; Kao, J.‐H.</creator><creatorcontrib>Tseng, T.‐C. ; Liu, C.‐J. ; Chen, C.‐L. ; Yang, W.‐T. ; Yang, H.‐C. ; Su, T.‐H. ; Wang, C.‐C. ; Kuo, S. F.‐T. ; Liu, C.‐H. ; Chen, P.‐J. ; Chen, D.‐S. ; Kao, J.‐H.</creatorcontrib><description>Summary
Background
Clearance of hepatitis B surface antigen (HBsAg) indicates clinical control of hepatitis B virus (HBV) infection. However, little is known about the impact of viral genomic variations on HBsAg loss.
Methods
We explored the association between viral genomic factors and HBsAg loss in 2121HBeAg‐negative patients. HBV pre‐core stop codon (1896) and basal core promoter (BCP) (1762/1764) sequences were determined in patients with HBV DNA ≥200 IU/mL (N = 1693). The effect of HBV genotype on HBsAg loss was further validated in the whole cohort of 3445 HBsAg carriers.
Results
The cumulative lifetime (age 28–75 years) incidence of HBsAg loss was 50.4% in 2121 HBeAg‐negative patients. We found that genotype C, but not pre‐core stop codon or BCP mutants, was associated with HBsAg loss. Compared to genotype B patients, genotype C patients had higher lifetime chance of HBsAg loss, with hazard ratio of 1.8 (95% confidence interval: 1.4–2.4). Multivariable analysis showed that male sex, elevated ALT levels, lower serum HBV DNA and HBsAg levels, and genotype C infection were associated with higher chance of HBsAg loss independently. We then performed sensitivity analysis, which re‐included HBeAg‐positive, cirrhotic and treatment‐experienced patients, and confirmed the robustness of our results in 3445 HBsAg carriers.
Conclusion
Genotype C infection, compared to genotype B, is associated with a higher lifetime chance of HBsAg loss in Asian HBV carriers.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/apt.13170</identifier><identifier>PMID: 25809540</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Aged ; Carrier State - virology ; Cohort Studies ; DNA, Viral - genetics ; Female ; Follow-Up Studies ; Genotype ; Hepatitis B - blood ; Hepatitis B Surface Antigens - blood ; Hepatitis B virus - genetics ; Humans ; Incidence ; Male ; Middle Aged</subject><ispartof>Alimentary pharmacology & therapeutics, 2015-05, Vol.41 (10), p.949-960</ispartof><rights>2015 John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3600-6289a56dc64889eca879614c6718021155cb88f3bd75b6e4675016e91c91ac923</citedby><cites>FETCH-LOGICAL-c3600-6289a56dc64889eca879614c6718021155cb88f3bd75b6e4675016e91c91ac923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapt.13170$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapt.13170$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25809540$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tseng, T.‐C.</creatorcontrib><creatorcontrib>Liu, C.‐J.</creatorcontrib><creatorcontrib>Chen, C.‐L.</creatorcontrib><creatorcontrib>Yang, W.‐T.</creatorcontrib><creatorcontrib>Yang, H.‐C.</creatorcontrib><creatorcontrib>Su, T.‐H.</creatorcontrib><creatorcontrib>Wang, C.‐C.</creatorcontrib><creatorcontrib>Kuo, S. F.‐T.</creatorcontrib><creatorcontrib>Liu, C.‐H.</creatorcontrib><creatorcontrib>Chen, P.‐J.</creatorcontrib><creatorcontrib>Chen, D.‐S.</creatorcontrib><creatorcontrib>Kao, J.‐H.</creatorcontrib><title>Higher lifetime chance of spontaneous surface antigen loss in hepatitis B carriers with genotype C infection</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background
Clearance of hepatitis B surface antigen (HBsAg) indicates clinical control of hepatitis B virus (HBV) infection. However, little is known about the impact of viral genomic variations on HBsAg loss.
Methods
We explored the association between viral genomic factors and HBsAg loss in 2121HBeAg‐negative patients. HBV pre‐core stop codon (1896) and basal core promoter (BCP) (1762/1764) sequences were determined in patients with HBV DNA ≥200 IU/mL (N = 1693). The effect of HBV genotype on HBsAg loss was further validated in the whole cohort of 3445 HBsAg carriers.
Results
The cumulative lifetime (age 28–75 years) incidence of HBsAg loss was 50.4% in 2121 HBeAg‐negative patients. We found that genotype C, but not pre‐core stop codon or BCP mutants, was associated with HBsAg loss. Compared to genotype B patients, genotype C patients had higher lifetime chance of HBsAg loss, with hazard ratio of 1.8 (95% confidence interval: 1.4–2.4). Multivariable analysis showed that male sex, elevated ALT levels, lower serum HBV DNA and HBsAg levels, and genotype C infection were associated with higher chance of HBsAg loss independently. We then performed sensitivity analysis, which re‐included HBeAg‐positive, cirrhotic and treatment‐experienced patients, and confirmed the robustness of our results in 3445 HBsAg carriers.
Conclusion
Genotype C infection, compared to genotype B, is associated with a higher lifetime chance of HBsAg loss in Asian HBV carriers.</description><subject>Adult</subject><subject>Aged</subject><subject>Carrier State - virology</subject><subject>Cohort Studies</subject><subject>DNA, Viral - genetics</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Genotype</subject><subject>Hepatitis B - blood</subject><subject>Hepatitis B Surface Antigens - blood</subject><subject>Hepatitis B virus - genetics</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Middle Aged</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LAzEQQIMotlYP_gHJUQ_bJvuRTY5a1AoFPdRzyKaz3ch-mWQp_fdGt3pzLgPD48E8hK4pmdMwC9X7OU1oTk7QlCYsi2KSsFM0JTETUcxpMkEXzn0QQlhO4nM0iTNORJaSKapXZleBxbUpwZsGsK5UqwF3JXZ913rVQjc47AZbqnBWrTc7aHHdOYdNiyvolTfeOPyAtbLWgHV4b3yFA9X5Qw94GbgStDdde4nOSlU7uDruGXp_etwsV9H69flleb-OdMIIiVjMhcrYVrOUcwFa8VwwmmqWU05iSrNMF5yXSbHNs4JByvKMUAaCakGVFnEyQ7ejt7fd5wDOy8Y4DXU9fiMpy1MqRMJJQO9GVNvwkoVS9tY0yh4kJfI7rgxx5U_cwN4ctUPRwPaP_K0ZgMUI7E0Nh_9N8v5tMyq_ABhig2U</recordid><startdate>201505</startdate><enddate>201505</enddate><creator>Tseng, T.‐C.</creator><creator>Liu, C.‐J.</creator><creator>Chen, C.‐L.</creator><creator>Yang, W.‐T.</creator><creator>Yang, H.‐C.</creator><creator>Su, T.‐H.</creator><creator>Wang, C.‐C.</creator><creator>Kuo, S. F.‐T.</creator><creator>Liu, C.‐H.</creator><creator>Chen, P.‐J.</creator><creator>Chen, D.‐S.</creator><creator>Kao, J.‐H.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201505</creationdate><title>Higher lifetime chance of spontaneous surface antigen loss in hepatitis B carriers with genotype C infection</title><author>Tseng, T.‐C. ; Liu, C.‐J. ; Chen, C.‐L. ; Yang, W.‐T. ; Yang, H.‐C. ; Su, T.‐H. ; Wang, C.‐C. ; Kuo, S. F.‐T. ; Liu, C.‐H. ; Chen, P.‐J. ; Chen, D.‐S. ; Kao, J.‐H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3600-6289a56dc64889eca879614c6718021155cb88f3bd75b6e4675016e91c91ac923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carrier State - virology</topic><topic>Cohort Studies</topic><topic>DNA, Viral - genetics</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Genotype</topic><topic>Hepatitis B - blood</topic><topic>Hepatitis B Surface Antigens - blood</topic><topic>Hepatitis B virus - genetics</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tseng, T.‐C.</creatorcontrib><creatorcontrib>Liu, C.‐J.</creatorcontrib><creatorcontrib>Chen, C.‐L.</creatorcontrib><creatorcontrib>Yang, W.‐T.</creatorcontrib><creatorcontrib>Yang, H.‐C.</creatorcontrib><creatorcontrib>Su, T.‐H.</creatorcontrib><creatorcontrib>Wang, C.‐C.</creatorcontrib><creatorcontrib>Kuo, S. F.‐T.</creatorcontrib><creatorcontrib>Liu, C.‐H.</creatorcontrib><creatorcontrib>Chen, P.‐J.</creatorcontrib><creatorcontrib>Chen, D.‐S.</creatorcontrib><creatorcontrib>Kao, J.‐H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tseng, T.‐C.</au><au>Liu, C.‐J.</au><au>Chen, C.‐L.</au><au>Yang, W.‐T.</au><au>Yang, H.‐C.</au><au>Su, T.‐H.</au><au>Wang, C.‐C.</au><au>Kuo, S. F.‐T.</au><au>Liu, C.‐H.</au><au>Chen, P.‐J.</au><au>Chen, D.‐S.</au><au>Kao, J.‐H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Higher lifetime chance of spontaneous surface antigen loss in hepatitis B carriers with genotype C infection</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2015-05</date><risdate>2015</risdate><volume>41</volume><issue>10</issue><spage>949</spage><epage>960</epage><pages>949-960</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Summary
Background
Clearance of hepatitis B surface antigen (HBsAg) indicates clinical control of hepatitis B virus (HBV) infection. However, little is known about the impact of viral genomic variations on HBsAg loss.
Methods
We explored the association between viral genomic factors and HBsAg loss in 2121HBeAg‐negative patients. HBV pre‐core stop codon (1896) and basal core promoter (BCP) (1762/1764) sequences were determined in patients with HBV DNA ≥200 IU/mL (N = 1693). The effect of HBV genotype on HBsAg loss was further validated in the whole cohort of 3445 HBsAg carriers.
Results
The cumulative lifetime (age 28–75 years) incidence of HBsAg loss was 50.4% in 2121 HBeAg‐negative patients. We found that genotype C, but not pre‐core stop codon or BCP mutants, was associated with HBsAg loss. Compared to genotype B patients, genotype C patients had higher lifetime chance of HBsAg loss, with hazard ratio of 1.8 (95% confidence interval: 1.4–2.4). Multivariable analysis showed that male sex, elevated ALT levels, lower serum HBV DNA and HBsAg levels, and genotype C infection were associated with higher chance of HBsAg loss independently. We then performed sensitivity analysis, which re‐included HBeAg‐positive, cirrhotic and treatment‐experienced patients, and confirmed the robustness of our results in 3445 HBsAg carriers.
Conclusion
Genotype C infection, compared to genotype B, is associated with a higher lifetime chance of HBsAg loss in Asian HBV carriers.</abstract><cop>England</cop><pmid>25809540</pmid><doi>10.1111/apt.13170</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0269-2813 |
| ispartof | Alimentary pharmacology & therapeutics, 2015-05, Vol.41 (10), p.949-960 |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Carrier State - virology Cohort Studies DNA, Viral - genetics Female Follow-Up Studies Genotype Hepatitis B - blood Hepatitis B Surface Antigens - blood Hepatitis B virus - genetics Humans Incidence Male Middle Aged |
| title | Higher lifetime chance of spontaneous surface antigen loss in hepatitis B carriers with genotype C infection |
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