Genotoxic effects of nicotine in combination with arecoline on CHO cells
Genotoxic effects of nicotine and arecoline, major alkaloids of tobacco and areca nut, respectively, were analysed in combination on CHO cells utilising two different cytogenetic end points, namely chromosome aberration frequency and sister chromatid exchange frequency. Statistically significant ele...
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| Veröffentlicht in: | Cancer letters 1993-10, Vol.74 (1), p.105-110 |
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| container_end_page | 110 |
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| container_issue | 1 |
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| container_title | Cancer letters |
| container_volume | 74 |
| creator | Trivedi, A.H. Dave, B.J. Adhvaryu, S.C. |
| description | Genotoxic effects of nicotine and arecoline, major alkaloids of tobacco and areca nut, respectively, were analysed in combination on CHO cells utilising two different cytogenetic end points, namely chromosome aberration frequency and sister chromatid exchange frequency. Statistically significant elevation in the values of both markers compared with controls, as well as nicotine alone, clearly indicated a more clastogenic and genotoxic effect following the addition of areca nut to tobacco. The effects observed following the treatment with a low dose for a longer duration are of relevance to the condition of oral mucosa of the chewers of tobacco with areca nut. |
| doi_str_mv | 10.1016/0304-3835(93)90051-A |
| format | Article |
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Statistically significant elevation in the values of both markers compared with controls, as well as nicotine alone, clearly indicated a more clastogenic and genotoxic effect following the addition of areca nut to tobacco. The effects observed following the treatment with a low dose for a longer duration are of relevance to the condition of oral mucosa of the chewers of tobacco with areca nut.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/0304-3835(93)90051-A</identifier><identifier>PMID: 8287363</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Arecoline ; Arecoline - toxicity ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Chemical agents ; CHO cells ; CHO Cells - drug effects ; Chromosome Aberrations ; Cricetinae ; Dose-Response Relationship, Drug ; Drug Synergism ; Genotoxicity ; Medical sciences ; Mutagenicity Tests ; Mutagens - toxicity ; Nicotine ; Nicotine - toxicity ; Sister Chromatid Exchange ; Tumors</subject><ispartof>Cancer letters, 1993-10, Vol.74 (1), p.105-110</ispartof><rights>1993</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-b902e5f0742ec877710172ad3c7a9a8af5aee6ea57006eca88bb26373feaad393</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3835(93)90051-A$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3813166$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8287363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trivedi, A.H.</creatorcontrib><creatorcontrib>Dave, B.J.</creatorcontrib><creatorcontrib>Adhvaryu, S.C.</creatorcontrib><title>Genotoxic effects of nicotine in combination with arecoline on CHO cells</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Genotoxic effects of nicotine and arecoline, major alkaloids of tobacco and areca nut, respectively, were analysed in combination on CHO cells utilising two different cytogenetic end points, namely chromosome aberration frequency and sister chromatid exchange frequency. Statistically significant elevation in the values of both markers compared with controls, as well as nicotine alone, clearly indicated a more clastogenic and genotoxic effect following the addition of areca nut to tobacco. The effects observed following the treatment with a low dose for a longer duration are of relevance to the condition of oral mucosa of the chewers of tobacco with areca nut.</description><subject>Animals</subject><subject>Arecoline</subject><subject>Arecoline - toxicity</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Chemical agents</subject><subject>CHO cells</subject><subject>CHO Cells - drug effects</subject><subject>Chromosome Aberrations</subject><subject>Cricetinae</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Synergism</subject><subject>Genotoxicity</subject><subject>Medical sciences</subject><subject>Mutagenicity Tests</subject><subject>Mutagens - toxicity</subject><subject>Nicotine</subject><subject>Nicotine - toxicity</subject><subject>Sister Chromatid Exchange</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo67r6DxR6ENFDNWnaJr0Iy6KusLAXPYc0nWCkTdYm68e_N3XLHj0F5n1mMvMgdE7wLcGkvMMU5ynltLiu6E2FcUHS-QGaEs6ylFUcH6LpHjlGJ96_4wjlrJigCc84oyWdouUTWBfct1EJaA0q-MTpxBrlgrGQGJso19XGymCcTb5MeEtkD8q1Qxori-U6UdC2_hQdadl6OBvfGXp9fHhZLNPV-ul5MV-lKicspHWFMyg0ZnkGijPG4ikskw1VTFaSS11IgBJkwTAuQUnO6zorKaMaZKQqOkNXu7mb3n1swQfRGT9sIC24rRekZHm8soxgvgNV77zvQYtNbzrZ_wiCxSBQDHbEYEdUVPwJFPPYdjHO39YdNPum0VjML8dceiVb3UurjN9jlBNKyuH3-x0G0cWngV54ZcAqaEzUF0TjzP97_AL67Ivf</recordid><startdate>19931015</startdate><enddate>19931015</enddate><creator>Trivedi, A.H.</creator><creator>Dave, B.J.</creator><creator>Adhvaryu, S.C.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19931015</creationdate><title>Genotoxic effects of nicotine in combination with arecoline on CHO cells</title><author>Trivedi, A.H. ; Dave, B.J. ; Adhvaryu, S.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-b902e5f0742ec877710172ad3c7a9a8af5aee6ea57006eca88bb26373feaad393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Arecoline</topic><topic>Arecoline - toxicity</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Chemical agents</topic><topic>CHO cells</topic><topic>CHO Cells - drug effects</topic><topic>Chromosome Aberrations</topic><topic>Cricetinae</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Synergism</topic><topic>Genotoxicity</topic><topic>Medical sciences</topic><topic>Mutagenicity Tests</topic><topic>Mutagens - toxicity</topic><topic>Nicotine</topic><topic>Nicotine - toxicity</topic><topic>Sister Chromatid Exchange</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trivedi, A.H.</creatorcontrib><creatorcontrib>Dave, B.J.</creatorcontrib><creatorcontrib>Adhvaryu, S.C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trivedi, A.H.</au><au>Dave, B.J.</au><au>Adhvaryu, S.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genotoxic effects of nicotine in combination with arecoline on CHO cells</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1993-10-15</date><risdate>1993</risdate><volume>74</volume><issue>1</issue><spage>105</spage><epage>110</epage><pages>105-110</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>Genotoxic effects of nicotine and arecoline, major alkaloids of tobacco and areca nut, respectively, were analysed in combination on CHO cells utilising two different cytogenetic end points, namely chromosome aberration frequency and sister chromatid exchange frequency. Statistically significant elevation in the values of both markers compared with controls, as well as nicotine alone, clearly indicated a more clastogenic and genotoxic effect following the addition of areca nut to tobacco. The effects observed following the treatment with a low dose for a longer duration are of relevance to the condition of oral mucosa of the chewers of tobacco with areca nut.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>8287363</pmid><doi>10.1016/0304-3835(93)90051-A</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 1993-10, Vol.74 (1), p.105-110 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Arecoline Arecoline - toxicity Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents CHO cells CHO Cells - drug effects Chromosome Aberrations Cricetinae Dose-Response Relationship, Drug Drug Synergism Genotoxicity Medical sciences Mutagenicity Tests Mutagens - toxicity Nicotine Nicotine - toxicity Sister Chromatid Exchange Tumors |
| title | Genotoxic effects of nicotine in combination with arecoline on CHO cells |
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