A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

Hyperhomocysteinaemia has been identified as a risk factor for cerebrovascular, peripheral vascular and coronary heart disease 1–4 . Elevated levels of plasma homocysteine can result from genetic or nutrient-related disturbances in the trans-sulphuration or re-methylation pathways for homocysteine m...

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Veröffentlicht in:	Nature genetics 1995-05, Vol.10 (1), p.111-113
Hauptverfasser:	Frosst, P, Blom, H.J, Milos, R, Goyette, P, Sheppard, C.A, Matthews, R.G, Boers, G.J.H, den Heijer, M, Kluijtmans, L.A.J, van den Heuve, L.P, Rozen, R
Format:	Artikel
Sprache:	eng
Schlagworte:	5,10-methylenetetrahydrofolate reductase Adult Agriculture Aminoacid disorders Animal Genetics and Genomics Base Sequence Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research DNA, Complementary Enzyme Stability Errors of metabolism Escherichia coli - metabolism Female Gene Function Homocysteine - metabolism Human Genetics Humans hyperhomocysteinemia Kidney - metabolism letter Liver - metabolism Lymphocytes - metabolism Male man Medical sciences Metabolic diseases Methylenetetrahydrofolate Reductase (NADPH2) Middle Aged Molecular Sequence Data MTHFR gene Mutagenesis, Site-Directed Mutation Oxidoreductases Acting on CH-NH Group Donors - deficiency Oxidoreductases Acting on CH-NH Group Donors - genetics Quebec Risk Factors Temperature vascular disease Vascular Diseases - epidemiology Vascular Diseases - genetics
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