Vaccarin promotes endothelial cell proliferation in association with neovascularization in vitro and in vivo

Angiogenesis is a major pathological component of several diseases, including traumatic vascular disease and coronary heart disease. The purpose of the present study was to determine the effects of vaccarin on endothelial cell migration and neovascularization, which are important and necessary compo...

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Veröffentlicht in:	Molecular medicine reports 2015-07, Vol.12 (1), p.1131-1136
Hauptverfasser:	XIE, FENGSHAN, FENG, LEI, CAI, WEIWEI, QIU, YUYU, LIU, YANLING, LI, YUE, DU, BIN, QIU, LIYING
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral AKT protein Angiogenesis Animals Cell adhesion & migration Cell growth Cell Line Cell migration Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Collagen - chemistry Coronary artery disease Disease Drug Combinations Endothelial cells Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism Epidermal growth factor Epidermal Growth Factor - pharmacology Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - metabolism Female Flavonoids Flavonoids - pharmacology Gene Expression Regulation Glycosides - pharmacology Heart diseases human microvascular endothelial cell Humans Humidity Immunohistochemistry Inoculation Laminin - chemistry Matrigel plus model Mice Mice, Inbred ICR Microvasculature Neovascularization, Physiologic - drug effects Oral administration Phosphorylation Platelet Endothelial Cell Adhesion Molecule-1 - genetics Platelet Endothelial Cell Adhesion Molecule-1 - metabolism proliferation Proteoglycans - chemistry Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Rhodamines Signal Transduction Studies Sulforhodamine vaccarin Vascularization vasculogenesis Wound healing
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