Outbreak of Pseudomonas aeruginosa bacteraemia in a haematology department

Infection by Pseudomonas aeruginosa represents a major cause of morbidity and mortality among immunocompromised patients. In Denmark, an increase in P. aeruginosa isolates from blood cultures from a haematology department prompted a hygienic audit in 2007. Blood cultures that tested positive for P....

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Veröffentlicht in:Danish medical journal 2015-04, Vol.62 (4), p.A5040-A5040
Hauptverfasser: Rasmussen, Benjamin Schnack, Christensen, Nikolas, Sørensen, Jan, Rosenvinge, Flemming S, Kolmos, Hans Jørn, Skov, Marianne N
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container_end_page A5040
container_issue 4
container_start_page A5040
container_title Danish medical journal
container_volume 62
creator Rasmussen, Benjamin Schnack
Christensen, Nikolas
Sørensen, Jan
Rosenvinge, Flemming S
Kolmos, Hans Jørn
Skov, Marianne N
description Infection by Pseudomonas aeruginosa represents a major cause of morbidity and mortality among immunocompromised patients. In Denmark, an increase in P. aeruginosa isolates from blood cultures from a haematology department prompted a hygienic audit in 2007. Blood cultures that tested positive for P. aeruginosa were collected from the laboratory information system (MADS, Skejby Hospital, Aarhus, Denmark). Environmental samples were obtained from shower heads in the department. The genotype was established by pulse field gel electrophoresis (PFGE). An audit was conducted during the outbreak and 12 months later. The audits were conducted by the method of direct observation. Several PFGE types were involved with no clear association to isolates from environmental samples. The audit revealed poor hygiene related to the handling of central venous catheters. After optimising catheter hygiene, the number of P. aeruginosa bacteraemia cases fell significantly. Since no clear association between patient and environmental genotype was established, it was suspected that central venous catheters were the main portal of entry. This was further supported by a simultaneous decline in bacteraemia cases with coagulase-negative staphylococci. Though several hygienic precautions were taken, the increased focus on disinfection of hubs and injection ports was presumably the more important element. not relevant. not relevant.
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Since no clear association between patient and environmental genotype was established, it was suspected that central venous catheters were the main portal of entry. This was further supported by a simultaneous decline in bacteraemia cases with coagulase-negative staphylococci. 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source MEDLINE; Alma/SFX Local Collection
subjects Aged
Bacteremia - epidemiology
Bacteremia - etiology
Catheter-Related Infections - epidemiology
Cohort Studies
Confidence Intervals
Cross Infection - epidemiology
Cross Infection - etiology
Denmark - epidemiology
Disease Outbreaks
Equipment Contamination
Female
Hematology
Hospital Departments
Humans
Immunocompromised Host
Incidence
Male
Middle Aged
Pseudomonas aeruginosa - isolation & purification
Pseudomonas Infections - epidemiology
Pseudomonas Infections - etiology
Regression Analysis
Retrospective Studies
Risk Assessment
title Outbreak of Pseudomonas aeruginosa bacteraemia in a haematology department
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