Outbreak of Pseudomonas aeruginosa bacteraemia in a haematology department
Infection by Pseudomonas aeruginosa represents a major cause of morbidity and mortality among immunocompromised patients. In Denmark, an increase in P. aeruginosa isolates from blood cultures from a haematology department prompted a hygienic audit in 2007. Blood cultures that tested positive for P....
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Veröffentlicht in: | Danish medical journal 2015-04, Vol.62 (4), p.A5040-A5040 |
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creator | Rasmussen, Benjamin Schnack Christensen, Nikolas Sørensen, Jan Rosenvinge, Flemming S Kolmos, Hans Jørn Skov, Marianne N |
description | Infection by Pseudomonas aeruginosa represents a major cause of morbidity and mortality among immunocompromised patients. In Denmark, an increase in P. aeruginosa isolates from blood cultures from a haematology department prompted a hygienic audit in 2007.
Blood cultures that tested positive for P. aeruginosa were collected from the laboratory information system (MADS, Skejby Hospital, Aarhus, Denmark). Environmental samples were obtained from shower heads in the department. The genotype was established by pulse field gel electrophoresis (PFGE). An audit was conducted during the outbreak and 12 months later. The audits were conducted by the method of direct observation.
Several PFGE types were involved with no clear association to isolates from environmental samples. The audit revealed poor hygiene related to the handling of central venous catheters. After optimising catheter hygiene, the number of P. aeruginosa bacteraemia cases fell significantly.
Since no clear association between patient and environmental genotype was established, it was suspected that central venous catheters were the main portal of entry. This was further supported by a simultaneous decline in bacteraemia cases with coagulase-negative staphylococci. Though several hygienic precautions were taken, the increased focus on disinfection of hubs and injection ports was presumably the more important element.
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Blood cultures that tested positive for P. aeruginosa were collected from the laboratory information system (MADS, Skejby Hospital, Aarhus, Denmark). Environmental samples were obtained from shower heads in the department. The genotype was established by pulse field gel electrophoresis (PFGE). An audit was conducted during the outbreak and 12 months later. The audits were conducted by the method of direct observation.
Several PFGE types were involved with no clear association to isolates from environmental samples. The audit revealed poor hygiene related to the handling of central venous catheters. After optimising catheter hygiene, the number of P. aeruginosa bacteraemia cases fell significantly.
Since no clear association between patient and environmental genotype was established, it was suspected that central venous catheters were the main portal of entry. This was further supported by a simultaneous decline in bacteraemia cases with coagulase-negative staphylococci. Though several hygienic precautions were taken, the increased focus on disinfection of hubs and injection ports was presumably the more important element.
not relevant.
not relevant.</description><identifier>EISSN: 2245-1919</identifier><identifier>PMID: 25872547</identifier><language>eng</language><publisher>Denmark</publisher><subject>Aged ; Bacteremia - epidemiology ; Bacteremia - etiology ; Catheter-Related Infections - epidemiology ; Cohort Studies ; Confidence Intervals ; Cross Infection - epidemiology ; Cross Infection - etiology ; Denmark - epidemiology ; Disease Outbreaks ; Equipment Contamination ; Female ; Hematology ; Hospital Departments ; Humans ; Immunocompromised Host ; Incidence ; Male ; Middle Aged ; Pseudomonas aeruginosa - isolation & purification ; Pseudomonas Infections - epidemiology ; Pseudomonas Infections - etiology ; Regression Analysis ; Retrospective Studies ; Risk Assessment</subject><ispartof>Danish medical journal, 2015-04, Vol.62 (4), p.A5040-A5040</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25872547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rasmussen, Benjamin Schnack</creatorcontrib><creatorcontrib>Christensen, Nikolas</creatorcontrib><creatorcontrib>Sørensen, Jan</creatorcontrib><creatorcontrib>Rosenvinge, Flemming S</creatorcontrib><creatorcontrib>Kolmos, Hans Jørn</creatorcontrib><creatorcontrib>Skov, Marianne N</creatorcontrib><title>Outbreak of Pseudomonas aeruginosa bacteraemia in a haematology department</title><title>Danish medical journal</title><addtitle>Dan Med J</addtitle><description>Infection by Pseudomonas aeruginosa represents a major cause of morbidity and mortality among immunocompromised patients. In Denmark, an increase in P. aeruginosa isolates from blood cultures from a haematology department prompted a hygienic audit in 2007.
Blood cultures that tested positive for P. aeruginosa were collected from the laboratory information system (MADS, Skejby Hospital, Aarhus, Denmark). Environmental samples were obtained from shower heads in the department. The genotype was established by pulse field gel electrophoresis (PFGE). An audit was conducted during the outbreak and 12 months later. The audits were conducted by the method of direct observation.
Several PFGE types were involved with no clear association to isolates from environmental samples. The audit revealed poor hygiene related to the handling of central venous catheters. After optimising catheter hygiene, the number of P. aeruginosa bacteraemia cases fell significantly.
Since no clear association between patient and environmental genotype was established, it was suspected that central venous catheters were the main portal of entry. This was further supported by a simultaneous decline in bacteraemia cases with coagulase-negative staphylococci. Though several hygienic precautions were taken, the increased focus on disinfection of hubs and injection ports was presumably the more important element.
not relevant.
not relevant.</description><subject>Aged</subject><subject>Bacteremia - epidemiology</subject><subject>Bacteremia - etiology</subject><subject>Catheter-Related Infections - epidemiology</subject><subject>Cohort Studies</subject><subject>Confidence Intervals</subject><subject>Cross Infection - epidemiology</subject><subject>Cross Infection - etiology</subject><subject>Denmark - epidemiology</subject><subject>Disease Outbreaks</subject><subject>Equipment Contamination</subject><subject>Female</subject><subject>Hematology</subject><subject>Hospital Departments</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>Incidence</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pseudomonas aeruginosa - isolation & purification</subject><subject>Pseudomonas Infections - epidemiology</subject><subject>Pseudomonas Infections - etiology</subject><subject>Regression Analysis</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><issn>2245-1919</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1jz1rwzAURUWhNCHNXygauxisJ9myxhL6SSAd2tk82c-pW8tyJXnIv6-hyV3OHQ4X7hVbA6giE0aYFdvG-J0vKaGsRH7DVlBUGgql1-ztMCcbCH-47_h7pLn1zo8YOVKYj_3oI3KLTaKA5Hrk_ciRfy0dkx_88cRbmjAkR2O6ZdcdDpG2Z27Y59Pjx-4l2x-eX3cP-2yCSqSs6BoUClRprdaNFAhFnqvGSFFgjth2JdjKYGVkq2yHShMK0I2QYCyILpcbdv-_OwX_O1NMtetjQ8OAI_k51qLUUhsQlVrUu7M6W0dtPYXeYTjVl__yDyfzVrU</recordid><startdate>201504</startdate><enddate>201504</enddate><creator>Rasmussen, Benjamin Schnack</creator><creator>Christensen, Nikolas</creator><creator>Sørensen, Jan</creator><creator>Rosenvinge, Flemming S</creator><creator>Kolmos, Hans Jørn</creator><creator>Skov, Marianne N</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201504</creationdate><title>Outbreak of Pseudomonas aeruginosa bacteraemia in a haematology department</title><author>Rasmussen, Benjamin Schnack ; Christensen, Nikolas ; Sørensen, Jan ; Rosenvinge, Flemming S ; Kolmos, Hans Jørn ; Skov, Marianne N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p281t-5fca14246bb77c31a25004c9315a0aadf62b89a893d4bfa47ea127c1329b21f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Bacteremia - epidemiology</topic><topic>Bacteremia - etiology</topic><topic>Catheter-Related Infections - epidemiology</topic><topic>Cohort Studies</topic><topic>Confidence Intervals</topic><topic>Cross Infection - epidemiology</topic><topic>Cross Infection - etiology</topic><topic>Denmark - epidemiology</topic><topic>Disease Outbreaks</topic><topic>Equipment Contamination</topic><topic>Female</topic><topic>Hematology</topic><topic>Hospital Departments</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>Incidence</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pseudomonas aeruginosa - isolation & purification</topic><topic>Pseudomonas Infections - epidemiology</topic><topic>Pseudomonas Infections - etiology</topic><topic>Regression Analysis</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><toplevel>online_resources</toplevel><creatorcontrib>Rasmussen, Benjamin Schnack</creatorcontrib><creatorcontrib>Christensen, Nikolas</creatorcontrib><creatorcontrib>Sørensen, Jan</creatorcontrib><creatorcontrib>Rosenvinge, Flemming S</creatorcontrib><creatorcontrib>Kolmos, Hans Jørn</creatorcontrib><creatorcontrib>Skov, Marianne N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Danish medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rasmussen, Benjamin Schnack</au><au>Christensen, Nikolas</au><au>Sørensen, Jan</au><au>Rosenvinge, Flemming S</au><au>Kolmos, Hans Jørn</au><au>Skov, Marianne N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outbreak of Pseudomonas aeruginosa bacteraemia in a haematology department</atitle><jtitle>Danish medical journal</jtitle><addtitle>Dan Med J</addtitle><date>2015-04</date><risdate>2015</risdate><volume>62</volume><issue>4</issue><spage>A5040</spage><epage>A5040</epage><pages>A5040-A5040</pages><eissn>2245-1919</eissn><abstract>Infection by Pseudomonas aeruginosa represents a major cause of morbidity and mortality among immunocompromised patients. In Denmark, an increase in P. aeruginosa isolates from blood cultures from a haematology department prompted a hygienic audit in 2007.
Blood cultures that tested positive for P. aeruginosa were collected from the laboratory information system (MADS, Skejby Hospital, Aarhus, Denmark). Environmental samples were obtained from shower heads in the department. The genotype was established by pulse field gel electrophoresis (PFGE). An audit was conducted during the outbreak and 12 months later. The audits were conducted by the method of direct observation.
Several PFGE types were involved with no clear association to isolates from environmental samples. The audit revealed poor hygiene related to the handling of central venous catheters. After optimising catheter hygiene, the number of P. aeruginosa bacteraemia cases fell significantly.
Since no clear association between patient and environmental genotype was established, it was suspected that central venous catheters were the main portal of entry. This was further supported by a simultaneous decline in bacteraemia cases with coagulase-negative staphylococci. Though several hygienic precautions were taken, the increased focus on disinfection of hubs and injection ports was presumably the more important element.
not relevant.
not relevant.</abstract><cop>Denmark</cop><pmid>25872547</pmid></addata></record> |
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source | MEDLINE; Alma/SFX Local Collection |
subjects | Aged Bacteremia - epidemiology Bacteremia - etiology Catheter-Related Infections - epidemiology Cohort Studies Confidence Intervals Cross Infection - epidemiology Cross Infection - etiology Denmark - epidemiology Disease Outbreaks Equipment Contamination Female Hematology Hospital Departments Humans Immunocompromised Host Incidence Male Middle Aged Pseudomonas aeruginosa - isolation & purification Pseudomonas Infections - epidemiology Pseudomonas Infections - etiology Regression Analysis Retrospective Studies Risk Assessment |
title | Outbreak of Pseudomonas aeruginosa bacteraemia in a haematology department |
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