Synergistic effects of oxyresveratrol in conjunction with antibiotics against methicillin-resistant Staphylococcus aureus
Methicillin-resistant Staphylococcus aureus (MRSA) infection is a serious clinical problem worldwide. The aim of the present study was to examine the antimicrobial activity of oxyresveratrol (ORV) against MRSA. The antimicrobial activity of ORV was evaluated against three strains of MRSA and one met...
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| Veröffentlicht in: | Molecular medicine reports 2015-07, Vol.12 (1), p.663-667 |
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| creator | JOUNG, DAE-KI CHOI, SUNG-HOON KANG, OK-HWA KIM, SUNG-BAE MUN, SU-HYUN SEO, YUN-SOO KANG, DA-HYE GONG, RYONG SHIN, DONG-WON KIM, YOUN-CHUL KWON, DONG-YEUL |
| description | Methicillin-resistant Staphylococcus aureus (MRSA) infection is a serious clinical problem worldwide. The aim of the present study was to examine the antimicrobial activity of oxyresveratrol (ORV) against MRSA. The antimicrobial activity of ORV was evaluated against three strains of MRSA and one methicillin-susceptible S. aureus (MSSA) strain using a minimal inhibitory concentration (MIC) assay, MTT colorimetric assay, checkerboard dilution test and time-kill assay. The MIC of ORV for all strains was moderate at 125 μg/ml. Of note, the antimicrobial activity and fractional inhibitory concentration index values of ORV were markedly increased in the presence of a non-growth inhibitory dose of certain antibiotics. Time-kill curves revealed that a combination of ORV with ciprofloxacin or with gentamicin reduced bacterial counts to below the lowest detectable limit after 24 h. These effective combinations may be used as potential antimicrobial regimens for use in the management of MRSA. |
| doi_str_mv | 10.3892/mmr.2015.3345 |
| format | Article |
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The aim of the present study was to examine the antimicrobial activity of oxyresveratrol (ORV) against MRSA. The antimicrobial activity of ORV was evaluated against three strains of MRSA and one methicillin-susceptible S. aureus (MSSA) strain using a minimal inhibitory concentration (MIC) assay, MTT colorimetric assay, checkerboard dilution test and time-kill assay. The MIC of ORV for all strains was moderate at 125 μg/ml. Of note, the antimicrobial activity and fractional inhibitory concentration index values of ORV were markedly increased in the presence of a non-growth inhibitory dose of certain antibiotics. Time-kill curves revealed that a combination of ORV with ciprofloxacin or with gentamicin reduced bacterial counts to below the lowest detectable limit after 24 h. These effective combinations may be used as potential antimicrobial regimens for use in the management of MRSA.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2015.3345</identifier><identifier>PMID: 25683461</identifier><language>eng</language><publisher>Greece: D.A. 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The aim of the present study was to examine the antimicrobial activity of oxyresveratrol (ORV) against MRSA. The antimicrobial activity of ORV was evaluated against three strains of MRSA and one methicillin-susceptible S. aureus (MSSA) strain using a minimal inhibitory concentration (MIC) assay, MTT colorimetric assay, checkerboard dilution test and time-kill assay. The MIC of ORV for all strains was moderate at 125 μg/ml. Of note, the antimicrobial activity and fractional inhibitory concentration index values of ORV were markedly increased in the presence of a non-growth inhibitory dose of certain antibiotics. Time-kill curves revealed that a combination of ORV with ciprofloxacin or with gentamicin reduced bacterial counts to below the lowest detectable limit after 24 h. These effective combinations may be used as potential antimicrobial regimens for use in the management of MRSA.</description><subject>Antibiotics</subject><subject>Antibiotics, Antitubercular - administration & dosage</subject><subject>antimicrobial</subject><subject>Antimicrobial activity</subject><subject>Antimicrobial agents</subject><subject>Bacteria</subject><subject>Bacterial infections</subject><subject>Ciprofloxacin</subject><subject>Ciprofloxacin - administration & dosage</subject><subject>Colorimetry</subject><subject>Drug resistance</subject><subject>Drug Synergism</subject><subject>Gentamicin</subject><subject>Gentamicins - administration & dosage</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Methicillin</subject><subject>methicillin-resistant Staphylococcus aureus</subject><subject>Methicillin-Resistant Staphylococcus aureus - drug effects</subject><subject>Methicillin-Resistant Staphylococcus aureus - pathogenicity</subject><subject>Minimum inhibitory concentration</subject><subject>Natural products</subject><subject>oxyresveratrol</subject><subject>Pathogens</subject><subject>Plant Extracts - administration & dosage</subject><subject>Resveratrol</subject><subject>Skin</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcal Infections - pathology</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus infections</subject><subject>Staphylococcus infections</subject><subject>Stilbenes - administration & dosage</subject><subject>Strains (organisms)</subject><subject>Studies</subject><subject>synergism</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkUuLFDEUhYMozji6dCsBF7qpNq9KVZbD4AsGXIyuQyp1052mKmmT1Gj9e9N0O6JICLmE7xwO9yD0kpIN7xV7N89pwwhtN5yL9hG6pJ2iDSdEPD7PTKnuAj3LeU-IbFmrnqIL1sqeC0kv0Xq3Bkhbn4u3GJwDWzKODsefa4J8D8mUFCfsA7Yx7Jdgi48B__Blh00ofvCxCjM2W-NDLniGsvPWT5MPTdVX20rhu2IOu3WKNlq7VHhJsOTn6IkzU4YX5_cKffvw_uvNp-b2y8fPN9e3jRWtKo0RiinmmKAgFbNMEQIdtM4Ng6kLsAOxlvDOUqaEBUV7w2nvejdKTusd-BV6e_I9pPh9gVz07LOFaTIB4pI1lR3vFGl7XtHX_6D7uKRQ02mqOBM1AJF_qK2ZQPvgYknGHk31tWC8lZx1qlKb_1D1jDD7uktwvv7_JWhOAptizgmcPiQ_m7RqSvSxal2r1seq9bHqyr86h12GGcYH-ne3FXhzAvLBhNGPMT8w1amhrCG0IVJy_gsL1LMP</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>JOUNG, DAE-KI</creator><creator>CHOI, SUNG-HOON</creator><creator>KANG, OK-HWA</creator><creator>KIM, SUNG-BAE</creator><creator>MUN, SU-HYUN</creator><creator>SEO, YUN-SOO</creator><creator>KANG, DA-HYE</creator><creator>GONG, RYONG</creator><creator>SHIN, DONG-WON</creator><creator>KIM, YOUN-CHUL</creator><creator>KWON, DONG-YEUL</creator><general>D.A. 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The aim of the present study was to examine the antimicrobial activity of oxyresveratrol (ORV) against MRSA. The antimicrobial activity of ORV was evaluated against three strains of MRSA and one methicillin-susceptible S. aureus (MSSA) strain using a minimal inhibitory concentration (MIC) assay, MTT colorimetric assay, checkerboard dilution test and time-kill assay. The MIC of ORV for all strains was moderate at 125 μg/ml. Of note, the antimicrobial activity and fractional inhibitory concentration index values of ORV were markedly increased in the presence of a non-growth inhibitory dose of certain antibiotics. Time-kill curves revealed that a combination of ORV with ciprofloxacin or with gentamicin reduced bacterial counts to below the lowest detectable limit after 24 h. These effective combinations may be used as potential antimicrobial regimens for use in the management of MRSA.</abstract><cop>Greece</cop><pub>D.A. 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| ispartof | Molecular medicine reports, 2015-07, Vol.12 (1), p.663-667 |
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| language | eng |
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| source | Spandidos Publications Journals; MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Antibiotics Antibiotics, Antitubercular - administration & dosage antimicrobial Antimicrobial activity Antimicrobial agents Bacteria Bacterial infections Ciprofloxacin Ciprofloxacin - administration & dosage Colorimetry Drug resistance Drug Synergism Gentamicin Gentamicins - administration & dosage Humans Infectious diseases Methicillin methicillin-resistant Staphylococcus aureus Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - pathogenicity Minimum inhibitory concentration Natural products oxyresveratrol Pathogens Plant Extracts - administration & dosage Resveratrol Skin Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcal Infections - pathology Staphylococcus aureus Staphylococcus aureus infections Staphylococcus infections Stilbenes - administration & dosage Strains (organisms) Studies synergism |
| title | Synergistic effects of oxyresveratrol in conjunction with antibiotics against methicillin-resistant Staphylococcus aureus |
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