Estrogen receptorβ2 regulates interlukin-12 receptorβ2 expression via p38 mitogen-activated protein kinase signaling and inhibits non-small-cell lung cancer proliferation and invasion

Lung cancer is one of the most common types of cancer and is the leading cause of cancer-related mortality worldwide. Estrogens are known to be involved in the development and progression of non-small-cell lung cancer (NSCLC). These effects are initially mediated through binding of estrogen to estro...

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Veröffentlicht in:	Molecular medicine reports 2015-07, Vol.12 (1), p.248-254
Hauptverfasser:	LIU, ZHAO-GUO, JIAO, XING-YUAN, CHEN, ZHEN-GUANG, FENG, KE, LUO, HONG-HE
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Bronchi - metabolism Bronchi - pathology Cell growth Cell Line, Tumor Cell migration Cell Movement Cell Nucleus - metabolism Cell Proliferation Cytoplasm Cytoplasm - metabolism Development and progression Diffusion Chambers, Culture Epithelial cells Epithelial Cells - metabolism Epithelial Cells - pathology Estrogen Receptor beta - genetics Estrogen Receptor beta - metabolism estrogen receptor β2 Estrogen receptors Estrogens Gene Expression Regulation, Neoplastic Growth factors Humans Interleukin 12 interleukin-12 receptorβ2 Invasiveness Kinases LTEP-a2 and H358 Lung cancer Lung cancer, Non-small cell Lungs MAP kinase Metastases Non-small cell lung carcinoma non-small-cell lung cancer Nuclei p38 mitogen-activated protein kinase p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Physiological aspects Plasmids Polymerase chain reaction proliferation and invasion Protein Binding Protein expression Protein Isoforms - genetics Protein Isoforms - metabolism Protein kinase Protein kinases Proteins Receptors, Interleukin-12 - antagonists & inhibitors Receptors, Interleukin-12 - genetics Receptors, Interleukin-12 - metabolism Reverse transcription RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Rodents Signal Transduction Studies Wound healing
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