Synergism between bovine papillomavirus type 4 and the flavonoid quercetin in cell transformation in vitro
Bovine papillomavirus type 4 (BPV-4) morphologically transforms primary bovine cells in vitro only in the presence of an activated ras gene. The transformed cells are capable of anchorage-independent growth, but are not immortal and are incapable of inducing tumors in nude mice, suggesting that othe...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 1992-10, Vol.190 (2), p.861-865 |
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| creator | Pennie, William D. Saveria Campo, M. |
| description | Bovine papillomavirus type 4 (BPV-4) morphologically transforms primary bovine cells
in vitro only in the presence of an activated
ras gene. The transformed cells are capable of anchorage-independent growth, but are not immortal and are incapable of inducing tumors in nude mice, suggesting that other events are needed to convert the cells to the fully transformed phenotype. We show here that treatment of the cells with a single dose of the flavonoid quercetin leads to full oncogenic transformation of cells transfected with BPV-4 and
ras. Quercetin is one of the most potent mutagens found in bracken fern, the environmental cofactor in BPV-4-associated carcinogenesis of the upper alimentary canal of cattle. Our results point to quercetin as the probable
in vivo cocarcinogen synergizing with BPV-4 in malignant progression. |
| doi_str_mv | 10.1016/0042-6822(92)90926-G |
| format | Article |
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in vitro only in the presence of an activated
ras gene. The transformed cells are capable of anchorage-independent growth, but are not immortal and are incapable of inducing tumors in nude mice, suggesting that other events are needed to convert the cells to the fully transformed phenotype. We show here that treatment of the cells with a single dose of the flavonoid quercetin leads to full oncogenic transformation of cells transfected with BPV-4 and
ras. Quercetin is one of the most potent mutagens found in bracken fern, the environmental cofactor in BPV-4-associated carcinogenesis of the upper alimentary canal of cattle. Our results point to quercetin as the probable
in vivo cocarcinogen synergizing with BPV-4 in malignant progression.</description><identifier>ISSN: 0042-6822</identifier><identifier>EISSN: 1096-0341</identifier><identifier>DOI: 10.1016/0042-6822(92)90926-G</identifier><identifier>PMID: 1325710</identifier><identifier>CODEN: VIRLAX</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>3T3 Cells ; Animals ; Biological and medical sciences ; BOVIN ; Bovine papillomavirus 1 - physiology ; Bovine papillomavirus 4 ; Carcinogenicity Tests ; Cattle ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Cell Transformation, Viral - drug effects ; Colony-Forming Units Assay ; CRECIMIENTO ; CROISSANCE ; CULTIVO DE CELULAS ; CULTURE DE CELLULE ; FIBROBLASTE ; FIBROBLASTOS ; FLAVONOIDE ; FLAVONOIDES ; Fundamental and applied biological sciences. Psychology ; GANADO BOVINO ; GENE ; GENES ; Genes, ras - genetics ; Mice ; Mice, Nude ; Molecular and cellular biology ; MUTAGENE ; MUTAGENOS ; NEOPLASMAS ; NEOPLASME ; ONCOGENICIDAD ; ONCOGENICITE ; PAPILLOMAVIRUS BOVIN ; Quercetin - pharmacology ; RATON ; SINERGISMO ; SOURIS ; SYNERGIE ; VIRUS ; VIRUS DEL PAPILOMA BOVINO</subject><ispartof>Virology (New York, N.Y.), 1992-10, Vol.190 (2), p.861-865</ispartof><rights>1992</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-fcd7c2e0de7ed5a9e75f06effff44e9242526f127fa163dbe895a5c444f389643</citedby><cites>FETCH-LOGICAL-c351t-fcd7c2e0de7ed5a9e75f06effff44e9242526f127fa163dbe895a5c444f389643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0042-6822(92)90926-G$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4394754$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1325710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pennie, William D.</creatorcontrib><creatorcontrib>Saveria Campo, M.</creatorcontrib><title>Synergism between bovine papillomavirus type 4 and the flavonoid quercetin in cell transformation in vitro</title><title>Virology (New York, N.Y.)</title><addtitle>Virology</addtitle><description>Bovine papillomavirus type 4 (BPV-4) morphologically transforms primary bovine cells
in vitro only in the presence of an activated
ras gene. The transformed cells are capable of anchorage-independent growth, but are not immortal and are incapable of inducing tumors in nude mice, suggesting that other events are needed to convert the cells to the fully transformed phenotype. We show here that treatment of the cells with a single dose of the flavonoid quercetin leads to full oncogenic transformation of cells transfected with BPV-4 and
ras. Quercetin is one of the most potent mutagens found in bracken fern, the environmental cofactor in BPV-4-associated carcinogenesis of the upper alimentary canal of cattle. Our results point to quercetin as the probable
in vivo cocarcinogen synergizing with BPV-4 in malignant progression.</description><subject>3T3 Cells</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>BOVIN</subject><subject>Bovine papillomavirus 1 - physiology</subject><subject>Bovine papillomavirus 4</subject><subject>Carcinogenicity Tests</subject><subject>Cattle</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>Cell Transformation, Viral - drug effects</subject><subject>Colony-Forming Units Assay</subject><subject>CRECIMIENTO</subject><subject>CROISSANCE</subject><subject>CULTIVO DE CELULAS</subject><subject>CULTURE DE CELLULE</subject><subject>FIBROBLASTE</subject><subject>FIBROBLASTOS</subject><subject>FLAVONOIDE</subject><subject>FLAVONOIDES</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GANADO BOVINO</subject><subject>GENE</subject><subject>GENES</subject><subject>Genes, ras - genetics</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Molecular and cellular biology</subject><subject>MUTAGENE</subject><subject>MUTAGENOS</subject><subject>NEOPLASMAS</subject><subject>NEOPLASME</subject><subject>ONCOGENICIDAD</subject><subject>ONCOGENICITE</subject><subject>PAPILLOMAVIRUS BOVIN</subject><subject>Quercetin - pharmacology</subject><subject>RATON</subject><subject>SINERGISMO</subject><subject>SOURIS</subject><subject>SYNERGIE</subject><subject>VIRUS</subject><subject>VIRUS DEL PAPILOMA BOVINO</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF9rFDEUxYModVv9AqKQBxF9GM2_mWxeClLqKhR8qH0O2eSmpsxMxiQ7st_ejLPUN8OFcHPOvTn8EHpNyUdKaPeJEMGabsvYe8U-KKJY1-yeoA0lqmsIF_Qp2jxanqPznB9I7aUkZ-iMctZKSjbo4fY4QroPecB7KL8BRryPcxgBT2YKfR8HM4d0yLgcJ8ACm9Hh8hOw780cxxgc_nWAZKGEEdey0Pe4JDNmH9NgSoh_n-dQUnyBnnnTZ3h5ui_Q3ZfrH1dfm5vvu29Xn28ay1taGm-dtAyIAwmuNQpk60kHvh4hQDHBWtZ5yqQ3tONuD1vVmtYKITzfqk7wC_Ru3TulWMPlooeQl2BmhHjImnaSC8YXo1iNNsWcE3g9pTCYdNSU6AWxXvjphZ9WtRbEelfH3pz2H_YDuH9DK9Oqvz3pJlvT-0rDhvxoE1wJ2S6_v1pt3kRt7lO13N0qzracsSperiJUUHOApLMNMFpwIYEt2sXw_5B_AHu3od4</recordid><startdate>199210</startdate><enddate>199210</enddate><creator>Pennie, William D.</creator><creator>Saveria Campo, M.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>199210</creationdate><title>Synergism between bovine papillomavirus type 4 and the flavonoid quercetin in cell transformation in vitro</title><author>Pennie, William D. ; Saveria Campo, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-fcd7c2e0de7ed5a9e75f06effff44e9242526f127fa163dbe895a5c444f389643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>3T3 Cells</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>BOVIN</topic><topic>Bovine papillomavirus 1 - physiology</topic><topic>Bovine papillomavirus 4</topic><topic>Carcinogenicity Tests</topic><topic>Cattle</topic><topic>Cell physiology</topic><topic>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</topic><topic>Cell Transformation, Viral - drug effects</topic><topic>Colony-Forming Units Assay</topic><topic>CRECIMIENTO</topic><topic>CROISSANCE</topic><topic>CULTIVO DE CELULAS</topic><topic>CULTURE DE CELLULE</topic><topic>FIBROBLASTE</topic><topic>FIBROBLASTOS</topic><topic>FLAVONOIDE</topic><topic>FLAVONOIDES</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GANADO BOVINO</topic><topic>GENE</topic><topic>GENES</topic><topic>Genes, ras - genetics</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Molecular and cellular biology</topic><topic>MUTAGENE</topic><topic>MUTAGENOS</topic><topic>NEOPLASMAS</topic><topic>NEOPLASME</topic><topic>ONCOGENICIDAD</topic><topic>ONCOGENICITE</topic><topic>PAPILLOMAVIRUS BOVIN</topic><topic>Quercetin - pharmacology</topic><topic>RATON</topic><topic>SINERGISMO</topic><topic>SOURIS</topic><topic>SYNERGIE</topic><topic>VIRUS</topic><topic>VIRUS DEL PAPILOMA BOVINO</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pennie, William D.</creatorcontrib><creatorcontrib>Saveria Campo, M.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Virology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pennie, William D.</au><au>Saveria Campo, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synergism between bovine papillomavirus type 4 and the flavonoid quercetin in cell transformation in vitro</atitle><jtitle>Virology (New York, N.Y.)</jtitle><addtitle>Virology</addtitle><date>1992-10</date><risdate>1992</risdate><volume>190</volume><issue>2</issue><spage>861</spage><epage>865</epage><pages>861-865</pages><issn>0042-6822</issn><eissn>1096-0341</eissn><coden>VIRLAX</coden><abstract>Bovine papillomavirus type 4 (BPV-4) morphologically transforms primary bovine cells
in vitro only in the presence of an activated
ras gene. The transformed cells are capable of anchorage-independent growth, but are not immortal and are incapable of inducing tumors in nude mice, suggesting that other events are needed to convert the cells to the fully transformed phenotype. We show here that treatment of the cells with a single dose of the flavonoid quercetin leads to full oncogenic transformation of cells transfected with BPV-4 and
ras. Quercetin is one of the most potent mutagens found in bracken fern, the environmental cofactor in BPV-4-associated carcinogenesis of the upper alimentary canal of cattle. Our results point to quercetin as the probable
in vivo cocarcinogen synergizing with BPV-4 in malignant progression.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>1325710</pmid><doi>10.1016/0042-6822(92)90926-G</doi><tpages>5</tpages></addata></record> |
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| ispartof | Virology (New York, N.Y.), 1992-10, Vol.190 (2), p.861-865 |
| issn | 0042-6822 1096-0341 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals |
| subjects | 3T3 Cells Animals Biological and medical sciences BOVIN Bovine papillomavirus 1 - physiology Bovine papillomavirus 4 Carcinogenicity Tests Cattle Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Viral - drug effects Colony-Forming Units Assay CRECIMIENTO CROISSANCE CULTIVO DE CELULAS CULTURE DE CELLULE FIBROBLASTE FIBROBLASTOS FLAVONOIDE FLAVONOIDES Fundamental and applied biological sciences. Psychology GANADO BOVINO GENE GENES Genes, ras - genetics Mice Mice, Nude Molecular and cellular biology MUTAGENE MUTAGENOS NEOPLASMAS NEOPLASME ONCOGENICIDAD ONCOGENICITE PAPILLOMAVIRUS BOVIN Quercetin - pharmacology RATON SINERGISMO SOURIS SYNERGIE VIRUS VIRUS DEL PAPILOMA BOVINO |
| title | Synergism between bovine papillomavirus type 4 and the flavonoid quercetin in cell transformation in vitro |
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