Effects of OPRM1 A118G polymorphism on epidural analgesia with fentanyl during labor: a meta-analysis
Emerging evidence has shown that the most common polymorphism (A118G; rs1799971 A>G) in the μ-opioid receptor (OPRM1) gene may influence the response to labor analgesia, but individually published studies showed inconclusive results. This meta-analysis aimed to derive a more precise estimation of...
Gespeichert in:
| Veröffentlicht in: | Genetic testing and molecular biomarkers 2013-10, Vol.17 (10), p.743-749 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 749 |
|---|---|
| container_issue | 10 |
| container_start_page | 743 |
| container_title | Genetic testing and molecular biomarkers |
| container_volume | 17 |
| creator | Song, Zheming Du, Boxiang Wang, Kai Shi, Xueyin |
| description | Emerging evidence has shown that the most common polymorphism (A118G; rs1799971 A>G) in the μ-opioid receptor (OPRM1) gene may influence the response to labor analgesia, but individually published studies showed inconclusive results.
This meta-analysis aimed to derive a more precise estimation of the effects of the OPRM1 A118G polymorphism on epidural analgesia with fentanyl during labor.
A literature search was conducted on PubMed, Embase, Web of Science, and China BioMedicine databases before April 1st, 2013. The crude standardized mean difference (SMD) or odds ratio (OR) with 95% confidence interval (CI) was calculated.
Six clinical studies were included with a total 838 women who received epidural analgesia with fentanyl during labor. The meta-analysis results indicated that women carrying the G allele (AG+GG) of the OPRM1 A118G polymorphism required less fentanyl doses to achieve adequate pain relief compared with those with the AA homozygote (SMD=-0.24, 95% CI [-0.44, -0.03], p=0.022). The 118G variant was associated with a decreased ED50 of fentanyl for labor analgesia (SMD=-1.56, 95% CI [-1.97, -1.15], p |
| doi_str_mv | 10.1089/gtmb.2013.0282 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1673397048</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1435845620</sourcerecordid><originalsourceid>FETCH-LOGICAL-c328t-7fbe68fd45045d600c9c47fabdaaa0078a0c1762a7a47b0d0d941627958b832e3</originalsourceid><addsrcrecordid>eNqFkT1LxEAQhhdRPD1tLWVLm8TZj-yHnYiegnIiWodJsntG8mU2QfLvvaBeazUD87xvMQ8hZwxiBsZeboY6izkwEQM3fI8cMSuTCHii93e7ShbkOIQPACWFUYdkwYUFKy07Iu7We5cPgbaerp9fnhi9ZsysaNdWU9323XsZato21HVlMfZYUWyw2rhQIv0qh3fqXTNgM1V0ey2bDa0wa_srirR2A0YzPIUynJADj1Vwp79zSd7ubl9v7qPH9erh5voxygU3Q6R95pTxhUxAJoUCyG0utcesQEQAbRByphVHjVJnUEBhJVNc28RkRnAnluTip7fr28_RhSGty5C7qsLGtWNImdJCWA3S_I9KkRiZKA5bNP5B874NoXc-7fqyxn5KGaSzhXS2kM4W0tnCNnD-2z1mtSt2-N_bxTdnMIJJ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1435845620</pqid></control><display><type>article</type><title>Effects of OPRM1 A118G polymorphism on epidural analgesia with fentanyl during labor: a meta-analysis</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Song, Zheming ; Du, Boxiang ; Wang, Kai ; Shi, Xueyin</creator><creatorcontrib>Song, Zheming ; Du, Boxiang ; Wang, Kai ; Shi, Xueyin</creatorcontrib><description>Emerging evidence has shown that the most common polymorphism (A118G; rs1799971 A>G) in the μ-opioid receptor (OPRM1) gene may influence the response to labor analgesia, but individually published studies showed inconclusive results.
This meta-analysis aimed to derive a more precise estimation of the effects of the OPRM1 A118G polymorphism on epidural analgesia with fentanyl during labor.
A literature search was conducted on PubMed, Embase, Web of Science, and China BioMedicine databases before April 1st, 2013. The crude standardized mean difference (SMD) or odds ratio (OR) with 95% confidence interval (CI) was calculated.
Six clinical studies were included with a total 838 women who received epidural analgesia with fentanyl during labor. The meta-analysis results indicated that women carrying the G allele (AG+GG) of the OPRM1 A118G polymorphism required less fentanyl doses to achieve adequate pain relief compared with those with the AA homozygote (SMD=-0.24, 95% CI [-0.44, -0.03], p=0.022). The 118G variant was associated with a decreased ED50 of fentanyl for labor analgesia (SMD=-1.56, 95% CI [-1.97, -1.15], p<0.001). The analgesia satisfaction in women carrying the G allele (AG+GG) was higher than those with the AA homozygote (SMD=0.22, 95% CI [0.05, 0.39], p=0.012). However, there were no statistically significant differences between an AA homozygote and a G carrier (AG+GG) in the incidence of nausea and vomiting (OR=1.99, 95% CI [0.88, 4.52], p=0.101).
In conclusion, the current meta-analysis indicates that women carrying the G allele (AG+GG) of OPRM1 A118G polymorphism may have a good response to epidural analgesia with fentanyl during labor. The OPRM1 A118G polymorphism may help predict individuals' response to epidural labor analgesia and so optimize postoperative pain control.</description><identifier>ISSN: 1945-0265</identifier><identifier>EISSN: 1945-0257</identifier><identifier>DOI: 10.1089/gtmb.2013.0282</identifier><identifier>PMID: 23909491</identifier><language>eng</language><publisher>United States</publisher><subject>Alleles ; Analgesia, Epidural ; Analgesics, Opioid - therapeutic use ; Clinical Trials as Topic ; Female ; Fentanyl - therapeutic use ; Homozygote ; Humans ; Labor, Obstetric - drug effects ; Labor, Obstetric - genetics ; Pain, Postoperative - drug therapy ; Pain, Postoperative - genetics ; Polymorphism, Genetic ; Pregnancy ; PubMed ; Receptors, Opioid, mu - genetics</subject><ispartof>Genetic testing and molecular biomarkers, 2013-10, Vol.17 (10), p.743-749</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-7fbe68fd45045d600c9c47fabdaaa0078a0c1762a7a47b0d0d941627958b832e3</citedby><cites>FETCH-LOGICAL-c328t-7fbe68fd45045d600c9c47fabdaaa0078a0c1762a7a47b0d0d941627958b832e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23909491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Zheming</creatorcontrib><creatorcontrib>Du, Boxiang</creatorcontrib><creatorcontrib>Wang, Kai</creatorcontrib><creatorcontrib>Shi, Xueyin</creatorcontrib><title>Effects of OPRM1 A118G polymorphism on epidural analgesia with fentanyl during labor: a meta-analysis</title><title>Genetic testing and molecular biomarkers</title><addtitle>Genet Test Mol Biomarkers</addtitle><description>Emerging evidence has shown that the most common polymorphism (A118G; rs1799971 A>G) in the μ-opioid receptor (OPRM1) gene may influence the response to labor analgesia, but individually published studies showed inconclusive results.
This meta-analysis aimed to derive a more precise estimation of the effects of the OPRM1 A118G polymorphism on epidural analgesia with fentanyl during labor.
A literature search was conducted on PubMed, Embase, Web of Science, and China BioMedicine databases before April 1st, 2013. The crude standardized mean difference (SMD) or odds ratio (OR) with 95% confidence interval (CI) was calculated.
Six clinical studies were included with a total 838 women who received epidural analgesia with fentanyl during labor. The meta-analysis results indicated that women carrying the G allele (AG+GG) of the OPRM1 A118G polymorphism required less fentanyl doses to achieve adequate pain relief compared with those with the AA homozygote (SMD=-0.24, 95% CI [-0.44, -0.03], p=0.022). The 118G variant was associated with a decreased ED50 of fentanyl for labor analgesia (SMD=-1.56, 95% CI [-1.97, -1.15], p<0.001). The analgesia satisfaction in women carrying the G allele (AG+GG) was higher than those with the AA homozygote (SMD=0.22, 95% CI [0.05, 0.39], p=0.012). However, there were no statistically significant differences between an AA homozygote and a G carrier (AG+GG) in the incidence of nausea and vomiting (OR=1.99, 95% CI [0.88, 4.52], p=0.101).
In conclusion, the current meta-analysis indicates that women carrying the G allele (AG+GG) of OPRM1 A118G polymorphism may have a good response to epidural analgesia with fentanyl during labor. The OPRM1 A118G polymorphism may help predict individuals' response to epidural labor analgesia and so optimize postoperative pain control.</description><subject>Alleles</subject><subject>Analgesia, Epidural</subject><subject>Analgesics, Opioid - therapeutic use</subject><subject>Clinical Trials as Topic</subject><subject>Female</subject><subject>Fentanyl - therapeutic use</subject><subject>Homozygote</subject><subject>Humans</subject><subject>Labor, Obstetric - drug effects</subject><subject>Labor, Obstetric - genetics</subject><subject>Pain, Postoperative - drug therapy</subject><subject>Pain, Postoperative - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Pregnancy</subject><subject>PubMed</subject><subject>Receptors, Opioid, mu - genetics</subject><issn>1945-0265</issn><issn>1945-0257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkT1LxEAQhhdRPD1tLWVLm8TZj-yHnYiegnIiWodJsntG8mU2QfLvvaBeazUD87xvMQ8hZwxiBsZeboY6izkwEQM3fI8cMSuTCHii93e7ShbkOIQPACWFUYdkwYUFKy07Iu7We5cPgbaerp9fnhi9ZsysaNdWU9323XsZato21HVlMfZYUWyw2rhQIv0qh3fqXTNgM1V0ey2bDa0wa_srirR2A0YzPIUynJADj1Vwp79zSd7ubl9v7qPH9erh5voxygU3Q6R95pTxhUxAJoUCyG0utcesQEQAbRByphVHjVJnUEBhJVNc28RkRnAnluTip7fr28_RhSGty5C7qsLGtWNImdJCWA3S_I9KkRiZKA5bNP5B874NoXc-7fqyxn5KGaSzhXS2kM4W0tnCNnD-2z1mtSt2-N_bxTdnMIJJ</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Song, Zheming</creator><creator>Du, Boxiang</creator><creator>Wang, Kai</creator><creator>Shi, Xueyin</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201310</creationdate><title>Effects of OPRM1 A118G polymorphism on epidural analgesia with fentanyl during labor: a meta-analysis</title><author>Song, Zheming ; Du, Boxiang ; Wang, Kai ; Shi, Xueyin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-7fbe68fd45045d600c9c47fabdaaa0078a0c1762a7a47b0d0d941627958b832e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Alleles</topic><topic>Analgesia, Epidural</topic><topic>Analgesics, Opioid - therapeutic use</topic><topic>Clinical Trials as Topic</topic><topic>Female</topic><topic>Fentanyl - therapeutic use</topic><topic>Homozygote</topic><topic>Humans</topic><topic>Labor, Obstetric - drug effects</topic><topic>Labor, Obstetric - genetics</topic><topic>Pain, Postoperative - drug therapy</topic><topic>Pain, Postoperative - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Pregnancy</topic><topic>PubMed</topic><topic>Receptors, Opioid, mu - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Zheming</creatorcontrib><creatorcontrib>Du, Boxiang</creatorcontrib><creatorcontrib>Wang, Kai</creatorcontrib><creatorcontrib>Shi, Xueyin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Genetic testing and molecular biomarkers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Zheming</au><au>Du, Boxiang</au><au>Wang, Kai</au><au>Shi, Xueyin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of OPRM1 A118G polymorphism on epidural analgesia with fentanyl during labor: a meta-analysis</atitle><jtitle>Genetic testing and molecular biomarkers</jtitle><addtitle>Genet Test Mol Biomarkers</addtitle><date>2013-10</date><risdate>2013</risdate><volume>17</volume><issue>10</issue><spage>743</spage><epage>749</epage><pages>743-749</pages><issn>1945-0265</issn><eissn>1945-0257</eissn><abstract>Emerging evidence has shown that the most common polymorphism (A118G; rs1799971 A>G) in the μ-opioid receptor (OPRM1) gene may influence the response to labor analgesia, but individually published studies showed inconclusive results.
This meta-analysis aimed to derive a more precise estimation of the effects of the OPRM1 A118G polymorphism on epidural analgesia with fentanyl during labor.
A literature search was conducted on PubMed, Embase, Web of Science, and China BioMedicine databases before April 1st, 2013. The crude standardized mean difference (SMD) or odds ratio (OR) with 95% confidence interval (CI) was calculated.
Six clinical studies were included with a total 838 women who received epidural analgesia with fentanyl during labor. The meta-analysis results indicated that women carrying the G allele (AG+GG) of the OPRM1 A118G polymorphism required less fentanyl doses to achieve adequate pain relief compared with those with the AA homozygote (SMD=-0.24, 95% CI [-0.44, -0.03], p=0.022). The 118G variant was associated with a decreased ED50 of fentanyl for labor analgesia (SMD=-1.56, 95% CI [-1.97, -1.15], p<0.001). The analgesia satisfaction in women carrying the G allele (AG+GG) was higher than those with the AA homozygote (SMD=0.22, 95% CI [0.05, 0.39], p=0.012). However, there were no statistically significant differences between an AA homozygote and a G carrier (AG+GG) in the incidence of nausea and vomiting (OR=1.99, 95% CI [0.88, 4.52], p=0.101).
In conclusion, the current meta-analysis indicates that women carrying the G allele (AG+GG) of OPRM1 A118G polymorphism may have a good response to epidural analgesia with fentanyl during labor. The OPRM1 A118G polymorphism may help predict individuals' response to epidural labor analgesia and so optimize postoperative pain control.</abstract><cop>United States</cop><pmid>23909491</pmid><doi>10.1089/gtmb.2013.0282</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1945-0265 |
| ispartof | Genetic testing and molecular biomarkers, 2013-10, Vol.17 (10), p.743-749 |
| issn | 1945-0265 1945-0257 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1673397048 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Alleles Analgesia, Epidural Analgesics, Opioid - therapeutic use Clinical Trials as Topic Female Fentanyl - therapeutic use Homozygote Humans Labor, Obstetric - drug effects Labor, Obstetric - genetics Pain, Postoperative - drug therapy Pain, Postoperative - genetics Polymorphism, Genetic Pregnancy PubMed Receptors, Opioid, mu - genetics |
| title | Effects of OPRM1 A118G polymorphism on epidural analgesia with fentanyl during labor: a meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T10%3A20%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20OPRM1%20A118G%20polymorphism%20on%20epidural%20analgesia%20with%20fentanyl%20during%20labor:%20a%20meta-analysis&rft.jtitle=Genetic%20testing%20and%20molecular%20biomarkers&rft.au=Song,%20Zheming&rft.date=2013-10&rft.volume=17&rft.issue=10&rft.spage=743&rft.epage=749&rft.pages=743-749&rft.issn=1945-0265&rft.eissn=1945-0257&rft_id=info:doi/10.1089/gtmb.2013.0282&rft_dat=%3Cproquest_cross%3E1435845620%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1435845620&rft_id=info:pmid/23909491&rfr_iscdi=true |