Fenofibrate reduces amyloidogenic processing of APP in APP/PS1 transgenic mice via PPAR-α/PI3-K pathway

•The levels of PPAR-α significantly reduced in the hippocampus of APP/PS1 transgenic mice.•Fenofibrate increased the levels of PPAR-α in the hippocampus of APP/PS1 transgenic mice.•Fenofibrate reduced the levels of BACE-1, sAPPβ, and Aβ42, but did not alter the expressions of AAP and PS1.•LY294002 r...

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Veröffentlicht in:	International journal of developmental neuroscience 2014-11, Vol.38 (1), p.223-231
Hauptverfasser:	Zhang, Hua, Gao, Ying, Qiao, Pei-feng, Zhao, Feng-li, Yan, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Amyloid precursor protein Amyloid Precursor Protein Secretases - metabolism Amyloid-β Amyloidosis - drug therapy Amyloidosis - genetics Animals Aspartic Acid Endopeptidases - metabolism Beta-site amyloid precursor protein cleaving enzyme 1 Disease Models, Animal Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Enzyme-Linked Immunosorbent Assay Fenofibrate Fenofibrate - therapeutic use Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Hypolipidemic Agents - therapeutic use Mice Mice, Transgenic Peptide Fragments - metabolism Peroxisome proliferator-activated receptor alpha Phosphatidylinositol 3-Kinases - metabolism Phosphoinositide 3-kinase PPAR alpha - metabolism Presenilin-1 - genetics Signal Transduction - drug effects Signal Transduction - genetics
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