Early life arsenic exposure and brain dopaminergic alterations in rats

•Impact of early life arsenic exposure investigated on brain dopaminergic alterations.•Arsenic increased DA-D2 receptors in corpus striatum associated with hyperactivity.•Dopaminergic alterations linked with mitochondrial dysfunctions and enhanced apoptosis.•Behavioral and neurochemical changes pers...

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Veröffentlicht in:	International journal of developmental neuroscience 2014-11, Vol.38 (1), p.91-104
Hauptverfasser:	Chandravanshi, Lalit P., Shukla, Rajendra K., Sultana, Sarwat, Pant, Aditya B., Khanna, Vinay K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Animals, Newborn Apoptosis Arsenic - toxicity bcl-2-Associated X Protein - metabolism Brain Caspase 3 - metabolism Corpus Striatum - drug effects Corpus Striatum - growth & development Corpus Striatum - metabolism Corpus Striatum - ultrastructure Dopamine - metabolism Dopaminergic system Dose-Response Relationship, Drug Exploratory Behavior - drug effects Gene Expression Regulation - drug effects Male Membrane Potential, Mitochondrial - drug effects Mitochondrial dysfunctions Motor Activity - drug effects Oxidative stress Oxidative Stress - drug effects Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Rats, Wistar Reactive Oxygen Species - metabolism Receptors, Dopamine - metabolism Tyrosine 3-Monooxygenase - metabolism
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