Increased expression of the regulatory T cell-associated marker CTLA-4 in bovine leukemia virus infection

Regulatory T cells (Tregs) play a critical role in the maintenance of the host's immune system. Tregs, particularly CD4+CD25+Foxp3+ T cells, have been reported to be involved in the immune evasion mechanism of tumors and several pathogens that cause chronic infections. Recent studies showed tha...

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Veröffentlicht in:	Veterinary immunology and immunopathology 2015-02, Vol.163 (3-4), p.115-124
Hauptverfasser:	Suzuki, Saori, Konnai, Satoru, Okagawa, Tomohiro, Ikebuchi, Ryoyo, Nishimori, Asami, Kohara, Junko, Mingala, Claro N., Murata, Shiro, Ohashi, Kazuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals BLV Bovine leukemia virus Cattle Cloning, Molecular CTLA-4 CTLA-4 Antigen - genetics CTLA-4 Antigen - metabolism Cytokines - genetics Cytokines - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enzootic Bovine Leukosis - metabolism Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Foxp3 Gene Expression Regulation, Viral - immunology Leukemia Virus, Bovine - immunology Molecular Sequence Data Phylogeny RNA, Messenger - genetics RNA, Messenger - metabolism T-Lymphocytes, Regulatory - metabolism TGF-β Treg
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