Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression

Down‐regulation of the liver‐specific MAT1A gene, encoding S‐adenosylmethionine (SAM) synthesizing isozymes MATI/III, and up‐regulation of widely expressed MAT2A, encoding MATII isozyme, known as MAT1A:MAT2A switch, occurs in hepatocellular carcinoma (HCC). Here we found Mat1A:Mat2A switch and low S...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2012-07, Vol.56 (1), p.165-175
Hauptverfasser:	Frau, Maddalena, Tomasi, Maria L., Simile, Maria M., Demartis, Maria I., Salis, Fabiana, Latte, Gavinella, Calvisi, Diego F., Seddaiu, Maria A., Daino, Lucia, Feo, Claudio F., Brozzetti, Stefania, Solinas, Giuliana, Yamashita, Satoshi, Ushijima, Toshikazu, Feo, Francesco, Pascale, Rosa M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Binding Sites Biological and medical sciences Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - pathology Cell cycle Cell growth Disease Models, Animal Disease Progression DNA Methylation Down-Regulation Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Enzymologic Hepatology Humans Kinases Liver - metabolism Liver cancer Liver Neoplasms - enzymology Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical prognosis Medical sciences Methionine Adenosyltransferase - genetics Methionine Adenosyltransferase - metabolism Multivariate Analysis Prognosis Promoter Regions, Genetic Proportional Hazards Models Rats Rats, Inbred BN Rats, Inbred F344 RNA, Messenger - metabolism Rodents S-Adenosylmethionine - metabolism Statistics, Nonparametric Transcriptional Activation Tumor Cells, Cultured Tumors
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