Hesperidin ameliorates behavioral impairments and neuropathology of transgenic APP/PS1 mice
•Potential therapeutic effects of hesperidin were investigated in transgenic APP/PS1 mice.•Hesperidin significantly ameliorated deficits in nesting and in social interactive behaviors.•Hesperidin significantly attenuated β-amyloid deposition and microglial activation in brain of these transgenic mic...
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| Veröffentlicht in: | Behavioural brain research 2015-03, Vol.281, p.32-42 |
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| creator | Li, Chaoyun Zug, Caroline Qu, Hongchun Schluesener, Hermann Zhang, Zhiyuan |
| description | •Potential therapeutic effects of hesperidin were investigated in transgenic APP/PS1 mice.•Hesperidin significantly ameliorated deficits in nesting and in social interactive behaviors.•Hesperidin significantly attenuated β-amyloid deposition and microglial activation in brain of these transgenic mice.
In addition to cognitive impairments, deficits in non-cognitive behaviors are also common neurological sequelae in Alzheimer's disease and its animal models. Hesperidin, a flavanone glycoside found abundantly in citrus fruits, was orally given (100mg/kg body weight) to 5-month-old transgenic APP/PS1 mice, a mouse model of cerebral amyloidosis for Alzheimer's disease. After a relatively short-term treatment of 10 days, hesperidin significantly restored deficits in non-cognitive nesting ability and social interaction. Further immunohistochemical analysis showed significantly attenuated β-amyloid deposition, plaque associated APP expression, microglial activation and TGF-β immunoreactivity in brains of APP/PS1 mice, which suggests that ameliorated behavioral impairments might be attributable to reduced Aβ deposition and attenuated neuro-inflammatory reaction. Additionally, efficient anti-inflammatory effects of hesperidin were confirmed in vitro. Our findings suggest that hesperidin might be a potential candidate for the treatment of AD or even other neurodegenerative diseases. |
| doi_str_mv | 10.1016/j.bbr.2014.12.012 |
| format | Article |
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In addition to cognitive impairments, deficits in non-cognitive behaviors are also common neurological sequelae in Alzheimer's disease and its animal models. Hesperidin, a flavanone glycoside found abundantly in citrus fruits, was orally given (100mg/kg body weight) to 5-month-old transgenic APP/PS1 mice, a mouse model of cerebral amyloidosis for Alzheimer's disease. After a relatively short-term treatment of 10 days, hesperidin significantly restored deficits in non-cognitive nesting ability and social interaction. Further immunohistochemical analysis showed significantly attenuated β-amyloid deposition, plaque associated APP expression, microglial activation and TGF-β immunoreactivity in brains of APP/PS1 mice, which suggests that ameliorated behavioral impairments might be attributable to reduced Aβ deposition and attenuated neuro-inflammatory reaction. Additionally, efficient anti-inflammatory effects of hesperidin were confirmed in vitro. Our findings suggest that hesperidin might be a potential candidate for the treatment of AD or even other neurodegenerative diseases.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2014.12.012</identifier><identifier>PMID: 25510196</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Alzheimer Disease - drug therapy ; Alzheimer Disease - pathology ; Alzheimer Disease - psychology ; Alzheimer's disease ; Amyloid beta-Protein Precursor - deficiency ; Amyloid beta-Protein Precursor - genetics ; Animals ; Behavioral deficit ; Brain - drug effects ; Brain - pathology ; Cerebral amyloidosis ; Citrus ; Disease Models, Animal ; Hesperidin ; Hesperidin - pharmacology ; Male ; Mice ; Mice, Transgenic ; Microglia - drug effects ; Microglia - immunology ; Neuro-inflammation ; Plaque, Amyloid - drug therapy ; Presenilin-1 - deficiency ; Presenilin-1 - genetics ; Psychomotor Performance - drug effects ; Social Behavior ; Transforming Growth Factor beta - immunology ; Transgenic mouse model ; Treatment Outcome</subject><ispartof>Behavioural brain research, 2015-03, Vol.281, p.32-42</ispartof><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-7a8d141804a9317099486130bda00d98becf6e3bb99bb730f5463cbdc512da513</citedby><cites>FETCH-LOGICAL-c386t-7a8d141804a9317099486130bda00d98becf6e3bb99bb730f5463cbdc512da513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbr.2014.12.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25510196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Chaoyun</creatorcontrib><creatorcontrib>Zug, Caroline</creatorcontrib><creatorcontrib>Qu, Hongchun</creatorcontrib><creatorcontrib>Schluesener, Hermann</creatorcontrib><creatorcontrib>Zhang, Zhiyuan</creatorcontrib><title>Hesperidin ameliorates behavioral impairments and neuropathology of transgenic APP/PS1 mice</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>•Potential therapeutic effects of hesperidin were investigated in transgenic APP/PS1 mice.•Hesperidin significantly ameliorated deficits in nesting and in social interactive behaviors.•Hesperidin significantly attenuated β-amyloid deposition and microglial activation in brain of these transgenic mice.
In addition to cognitive impairments, deficits in non-cognitive behaviors are also common neurological sequelae in Alzheimer's disease and its animal models. Hesperidin, a flavanone glycoside found abundantly in citrus fruits, was orally given (100mg/kg body weight) to 5-month-old transgenic APP/PS1 mice, a mouse model of cerebral amyloidosis for Alzheimer's disease. After a relatively short-term treatment of 10 days, hesperidin significantly restored deficits in non-cognitive nesting ability and social interaction. Further immunohistochemical analysis showed significantly attenuated β-amyloid deposition, plaque associated APP expression, microglial activation and TGF-β immunoreactivity in brains of APP/PS1 mice, which suggests that ameliorated behavioral impairments might be attributable to reduced Aβ deposition and attenuated neuro-inflammatory reaction. Additionally, efficient anti-inflammatory effects of hesperidin were confirmed in vitro. Our findings suggest that hesperidin might be a potential candidate for the treatment of AD or even other neurodegenerative diseases.</description><subject>Alzheimer Disease - drug therapy</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer Disease - psychology</subject><subject>Alzheimer's disease</subject><subject>Amyloid beta-Protein Precursor - deficiency</subject><subject>Amyloid beta-Protein Precursor - genetics</subject><subject>Animals</subject><subject>Behavioral deficit</subject><subject>Brain - drug effects</subject><subject>Brain - pathology</subject><subject>Cerebral amyloidosis</subject><subject>Citrus</subject><subject>Disease Models, Animal</subject><subject>Hesperidin</subject><subject>Hesperidin - pharmacology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Microglia - drug effects</subject><subject>Microglia - immunology</subject><subject>Neuro-inflammation</subject><subject>Plaque, Amyloid - drug therapy</subject><subject>Presenilin-1 - deficiency</subject><subject>Presenilin-1 - genetics</subject><subject>Psychomotor Performance - drug effects</subject><subject>Social Behavior</subject><subject>Transforming Growth Factor beta - immunology</subject><subject>Transgenic mouse model</subject><subject>Treatment Outcome</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtr3DAURkVpaCZpf0A3Rctu7OjqYVt0FULzgEAG2q66EHpcJxpsy5U8gfz7epi0y9LV5cL5zuIQ8hFYDQyai13tXK45A1kDrxnwN2QDXcurVkn9lmxWpqmk4N0pOStlxxiTTME7csqVWgW62ZCft1hmzDHEidoRh5iyXbBQh0_2-fAMNI6zjXnEaSnUToFOuM9ptstTGtLjC009XbKdyiNO0dPL7fZi-w3oGD2-Jye9HQp-eL3n5Mf11-9Xt9X9w83d1eV95UXXLFVruwASOiatFtAyrWXXgGAuWMaC7hz6vkHhnNbOtYL1SjbCu-AV8GAViHPy-eidc_q1x7KYMRaPw2AnTPtioGmFaHWn2H-giksBXIsVhSPqcyolY2_mHEebXwwwc8hvdmbNbw75DXCz5l83n171ezdi-Lv403sFvhwBXHs8R8ym-IiTxxAz-sWEFP-h_w2aiZUH</recordid><startdate>20150315</startdate><enddate>20150315</enddate><creator>Li, Chaoyun</creator><creator>Zug, Caroline</creator><creator>Qu, Hongchun</creator><creator>Schluesener, Hermann</creator><creator>Zhang, Zhiyuan</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>20150315</creationdate><title>Hesperidin ameliorates behavioral impairments and neuropathology of transgenic APP/PS1 mice</title><author>Li, Chaoyun ; Zug, Caroline ; Qu, Hongchun ; Schluesener, Hermann ; Zhang, Zhiyuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-7a8d141804a9317099486130bda00d98becf6e3bb99bb730f5463cbdc512da513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Alzheimer Disease - drug therapy</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer Disease - psychology</topic><topic>Alzheimer's disease</topic><topic>Amyloid beta-Protein Precursor - deficiency</topic><topic>Amyloid beta-Protein Precursor - genetics</topic><topic>Animals</topic><topic>Behavioral deficit</topic><topic>Brain - drug effects</topic><topic>Brain - pathology</topic><topic>Cerebral amyloidosis</topic><topic>Citrus</topic><topic>Disease Models, Animal</topic><topic>Hesperidin</topic><topic>Hesperidin - pharmacology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Microglia - drug effects</topic><topic>Microglia - immunology</topic><topic>Neuro-inflammation</topic><topic>Plaque, Amyloid - drug therapy</topic><topic>Presenilin-1 - deficiency</topic><topic>Presenilin-1 - genetics</topic><topic>Psychomotor Performance - drug effects</topic><topic>Social Behavior</topic><topic>Transforming Growth Factor beta - immunology</topic><topic>Transgenic mouse model</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Chaoyun</creatorcontrib><creatorcontrib>Zug, Caroline</creatorcontrib><creatorcontrib>Qu, Hongchun</creatorcontrib><creatorcontrib>Schluesener, Hermann</creatorcontrib><creatorcontrib>Zhang, Zhiyuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Chaoyun</au><au>Zug, Caroline</au><au>Qu, Hongchun</au><au>Schluesener, Hermann</au><au>Zhang, Zhiyuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hesperidin ameliorates behavioral impairments and neuropathology of transgenic APP/PS1 mice</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2015-03-15</date><risdate>2015</risdate><volume>281</volume><spage>32</spage><epage>42</epage><pages>32-42</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><abstract>•Potential therapeutic effects of hesperidin were investigated in transgenic APP/PS1 mice.•Hesperidin significantly ameliorated deficits in nesting and in social interactive behaviors.•Hesperidin significantly attenuated β-amyloid deposition and microglial activation in brain of these transgenic mice.
In addition to cognitive impairments, deficits in non-cognitive behaviors are also common neurological sequelae in Alzheimer's disease and its animal models. Hesperidin, a flavanone glycoside found abundantly in citrus fruits, was orally given (100mg/kg body weight) to 5-month-old transgenic APP/PS1 mice, a mouse model of cerebral amyloidosis for Alzheimer's disease. After a relatively short-term treatment of 10 days, hesperidin significantly restored deficits in non-cognitive nesting ability and social interaction. Further immunohistochemical analysis showed significantly attenuated β-amyloid deposition, plaque associated APP expression, microglial activation and TGF-β immunoreactivity in brains of APP/PS1 mice, which suggests that ameliorated behavioral impairments might be attributable to reduced Aβ deposition and attenuated neuro-inflammatory reaction. Additionally, efficient anti-inflammatory effects of hesperidin were confirmed in vitro. Our findings suggest that hesperidin might be a potential candidate for the treatment of AD or even other neurodegenerative diseases.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25510196</pmid><doi>10.1016/j.bbr.2014.12.012</doi><tpages>11</tpages></addata></record> |
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| subjects | Alzheimer Disease - drug therapy Alzheimer Disease - pathology Alzheimer Disease - psychology Alzheimer's disease Amyloid beta-Protein Precursor - deficiency Amyloid beta-Protein Precursor - genetics Animals Behavioral deficit Brain - drug effects Brain - pathology Cerebral amyloidosis Citrus Disease Models, Animal Hesperidin Hesperidin - pharmacology Male Mice Mice, Transgenic Microglia - drug effects Microglia - immunology Neuro-inflammation Plaque, Amyloid - drug therapy Presenilin-1 - deficiency Presenilin-1 - genetics Psychomotor Performance - drug effects Social Behavior Transforming Growth Factor beta - immunology Transgenic mouse model Treatment Outcome |
| title | Hesperidin ameliorates behavioral impairments and neuropathology of transgenic APP/PS1 mice |
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