Insights into the mechanisms of chitosan–anionic polymers-based matrix tablets for extended drug release

[Display omitted] The aim of this study was to investigate drug release mechanisms from physical mixtures of chitosan–anionic polymers-based matrix tablets and to obtain a comprehensive understanding about release characteristics. Six types of anionic polymers (i.e., Eudragit® L100, sodium alginate,...

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Veröffentlicht in:	International journal of pharmaceutics 2014-12, Vol.476 (1-2), p.253-265
Hauptverfasser:	Li, Liang, Wang, Linlin, Li, Jinfeng, Jiang, Shan, Wang, Yitong, Zhang, Xin, Ding, Jiaojiao, Yu, Tongya, Mao, Shirui
Format:	Artikel
Sprache:	eng
Schlagworte:	Anionic polymer Anions Calorimetry, Differential Scanning Chemistry, Pharmaceutical - methods Chitosan Chitosan - chemistry Delayed-Action Preparations Drug Liberation Gastrointestinal Tract - metabolism Hydrogen-Ion Concentration Hydrophilic matrices Matrix tablets Metoprolol - administration & dosage Metoprolol - analogs & derivatives Metoprolol - chemistry Oral controlled release/delivery Polyelectrolyte complexes Polymers - chemistry Solubility Spectroscopy, Fourier Transform Infrared Tablets Theophylline - administration & dosage Theophylline - chemistry
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