Association of mutation patterns in GyrA and ParC genes with quinolone resistance levels in lactic acid bacteria
The quinolone resistance of 19 lactic acid bacterial strains belonging to the genera Enterococcus and Lactobacillus isolated from the natural fermented koumiss and yoghurt were investigated. The objective of this study was to determine the quinolone resistance levels and to explore the association o...
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| Veröffentlicht in: | Journal of antibiotics 2015-02, Vol.68 (2), p.81-87 |
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| creator | Li, Shaoying Li, Zhen Wei, Wan Ma, Chunyan Song, Xiaomin Li, Shufen He, Wenying Tian, Jianjun Huo, Xiaoyan |
| description | The quinolone resistance of 19 lactic acid bacterial strains belonging to the genera
Enterococcus
and
Lactobacillus
isolated from the natural fermented koumiss and yoghurt were investigated. The objective of this study was to determine the quinolone resistance levels and to explore the association of the resistance with the mutation patterns in
gyrA
and
parC
genes, as is currently recommended by the Food and Agriculture Organization/World Health Organization Joint Expert Committee in Guidelines for Evaluation of Probiotics in Food for probiotic lactic acid bacteria drug resistance in 2001. The Oxford Cup method and double-tube dilution method were used to determine the quinolone resistance levels of the isolated strains. Generally, all of the 19 strains showed resistance towards norfloxacin and ciprofloxacin when the Oxford cup method was used, whereas the incidence was lower (to norfloxacin 89.5% and to ciprofloxacin 68.4%) when minimum inhibitory concentration breakpoints (CLSI M100-S23) were tested. Furthermore, gene sequencing was conducted on
gyrA
and
parC
of topoisomerase II of these isolated strains. The genetic basis for quinolone resistance may be closely related to mutations in
gyrA
genes as there were 10 mutation sites in amino-acid sequences encoded by
gyrA
genes in 10 quinolone resistance strains and 14 mutation sites in
Enterococcus durans
HZ28, whereas no typical mutations were detected in
parC
genes. |
| doi_str_mv | 10.1038/ja.2014.113 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1673377720</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2331616112</sourcerecordid><originalsourceid>FETCH-LOGICAL-c406t-48371c95ddd0f56206abdf9d21aad9f64b9d8ed0855cd07ab9f302b3b8fed5d53</originalsourceid><addsrcrecordid>eNp9kdFrFDEQxoNY7Fl98l0Cvgi65yTZ3WQfj0OrUGgf9Dlkk9maYy-5JtlK_3vTXhURkXmYgfnNN8N8hLxisGYg1IedWXNg7Zox8YSsmFKsYW0_PCUrAM4apTickuc57wCEFFI9I6e849CKtluRwybnaL0pPgYaJ7pfyrE-mFIwhUx9oOd3aUNNcPTKpC29xoCZ_vDlO71ZfIhzDEgTZp-LCRbpjLc4P8zNxhZvqbHe0bHWmLx5QU4mM2d8-ZjPyLdPH79uPzcXl-dftpuLxrbQl6ZVQjI7dM45mLqeQ29GNw2OM2PcMPXtODiFDlTXWQfSjMMkgI9iVBO6znXijLw96h5SvFkwF7332eI8m4BxyZr1UggpJYeKvvkL3cUlhXqd5kKwvgbj_6OYVH19s2hZpd4dKZtizgknfUh-b9KdZqDv7dI7o-_t0tWuSr9-1FzGPbrf7C9_KvD-COTaCteY_lj6D72fP3-eMA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1786882341</pqid></control><display><type>article</type><title>Association of mutation patterns in GyrA and ParC genes with quinolone resistance levels in lactic acid bacteria</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Li, Shaoying ; Li, Zhen ; Wei, Wan ; Ma, Chunyan ; Song, Xiaomin ; Li, Shufen ; He, Wenying ; Tian, Jianjun ; Huo, Xiaoyan</creator><creatorcontrib>Li, Shaoying ; Li, Zhen ; Wei, Wan ; Ma, Chunyan ; Song, Xiaomin ; Li, Shufen ; He, Wenying ; Tian, Jianjun ; Huo, Xiaoyan</creatorcontrib><description>The quinolone resistance of 19 lactic acid bacterial strains belonging to the genera
Enterococcus
and
Lactobacillus
isolated from the natural fermented koumiss and yoghurt were investigated. The objective of this study was to determine the quinolone resistance levels and to explore the association of the resistance with the mutation patterns in
gyrA
and
parC
genes, as is currently recommended by the Food and Agriculture Organization/World Health Organization Joint Expert Committee in Guidelines for Evaluation of Probiotics in Food for probiotic lactic acid bacteria drug resistance in 2001. The Oxford Cup method and double-tube dilution method were used to determine the quinolone resistance levels of the isolated strains. Generally, all of the 19 strains showed resistance towards norfloxacin and ciprofloxacin when the Oxford cup method was used, whereas the incidence was lower (to norfloxacin 89.5% and to ciprofloxacin 68.4%) when minimum inhibitory concentration breakpoints (CLSI M100-S23) were tested. Furthermore, gene sequencing was conducted on
gyrA
and
parC
of topoisomerase II of these isolated strains. The genetic basis for quinolone resistance may be closely related to mutations in
gyrA
genes as there were 10 mutation sites in amino-acid sequences encoded by
gyrA
genes in 10 quinolone resistance strains and 14 mutation sites in
Enterococcus durans
HZ28, whereas no typical mutations were detected in
parC
genes.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.1038/ja.2014.113</identifier><identifier>PMID: 25204345</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>38 ; 38/77 ; 45/23 ; 631/326/22/1434 ; Acids ; Amino Acid Sequence ; Anti-Bacterial Agents - pharmacology ; Bacteria ; Bacteriology ; Biomedical and Life Sciences ; Bioorganic Chemistry ; Ciprofloxacin - pharmacology ; Cultured Milk Products - microbiology ; DNA Gyrase - genetics ; DNA Topoisomerase IV - genetics ; DNA Topoisomerases, Type II - genetics ; Drug resistance ; Drug Resistance, Bacterial - genetics ; Enterococcus - drug effects ; Enterococcus - genetics ; Enterococcus - isolation & purification ; Lactic Acid - metabolism ; Lactobacillus - drug effects ; Lactobacillus - genetics ; Lactobacillus - isolation & purification ; Life Sciences ; Medicinal Chemistry ; Microbial Sensitivity Tests ; Microbiology ; Mutation ; Norfloxacin - pharmacology ; Organic Chemistry ; original-article ; Quinolones - pharmacology ; Yogurt ; Yogurt - microbiology</subject><ispartof>Journal of antibiotics, 2015-02, Vol.68 (2), p.81-87</ispartof><rights>Japan Antibiotics Research Association 2015</rights><rights>Copyright Nature Publishing Group Feb 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-48371c95ddd0f56206abdf9d21aad9f64b9d8ed0855cd07ab9f302b3b8fed5d53</citedby><cites>FETCH-LOGICAL-c406t-48371c95ddd0f56206abdf9d21aad9f64b9d8ed0855cd07ab9f302b3b8fed5d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25204345$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Shaoying</creatorcontrib><creatorcontrib>Li, Zhen</creatorcontrib><creatorcontrib>Wei, Wan</creatorcontrib><creatorcontrib>Ma, Chunyan</creatorcontrib><creatorcontrib>Song, Xiaomin</creatorcontrib><creatorcontrib>Li, Shufen</creatorcontrib><creatorcontrib>He, Wenying</creatorcontrib><creatorcontrib>Tian, Jianjun</creatorcontrib><creatorcontrib>Huo, Xiaoyan</creatorcontrib><title>Association of mutation patterns in GyrA and ParC genes with quinolone resistance levels in lactic acid bacteria</title><title>Journal of antibiotics</title><addtitle>J Antibiot</addtitle><addtitle>J Antibiot (Tokyo)</addtitle><description>The quinolone resistance of 19 lactic acid bacterial strains belonging to the genera
Enterococcus
and
Lactobacillus
isolated from the natural fermented koumiss and yoghurt were investigated. The objective of this study was to determine the quinolone resistance levels and to explore the association of the resistance with the mutation patterns in
gyrA
and
parC
genes, as is currently recommended by the Food and Agriculture Organization/World Health Organization Joint Expert Committee in Guidelines for Evaluation of Probiotics in Food for probiotic lactic acid bacteria drug resistance in 2001. The Oxford Cup method and double-tube dilution method were used to determine the quinolone resistance levels of the isolated strains. Generally, all of the 19 strains showed resistance towards norfloxacin and ciprofloxacin when the Oxford cup method was used, whereas the incidence was lower (to norfloxacin 89.5% and to ciprofloxacin 68.4%) when minimum inhibitory concentration breakpoints (CLSI M100-S23) were tested. Furthermore, gene sequencing was conducted on
gyrA
and
parC
of topoisomerase II of these isolated strains. The genetic basis for quinolone resistance may be closely related to mutations in
gyrA
genes as there were 10 mutation sites in amino-acid sequences encoded by
gyrA
genes in 10 quinolone resistance strains and 14 mutation sites in
Enterococcus durans
HZ28, whereas no typical mutations were detected in
parC
genes.</description><subject>38</subject><subject>38/77</subject><subject>45/23</subject><subject>631/326/22/1434</subject><subject>Acids</subject><subject>Amino Acid Sequence</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacteria</subject><subject>Bacteriology</subject><subject>Biomedical and Life Sciences</subject><subject>Bioorganic Chemistry</subject><subject>Ciprofloxacin - pharmacology</subject><subject>Cultured Milk Products - microbiology</subject><subject>DNA Gyrase - genetics</subject><subject>DNA Topoisomerase IV - genetics</subject><subject>DNA Topoisomerases, Type II - genetics</subject><subject>Drug resistance</subject><subject>Drug Resistance, Bacterial - genetics</subject><subject>Enterococcus - drug effects</subject><subject>Enterococcus - genetics</subject><subject>Enterococcus - isolation & purification</subject><subject>Lactic Acid - metabolism</subject><subject>Lactobacillus - drug effects</subject><subject>Lactobacillus - genetics</subject><subject>Lactobacillus - isolation & purification</subject><subject>Life Sciences</subject><subject>Medicinal Chemistry</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Mutation</subject><subject>Norfloxacin - pharmacology</subject><subject>Organic Chemistry</subject><subject>original-article</subject><subject>Quinolones - pharmacology</subject><subject>Yogurt</subject><subject>Yogurt - microbiology</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kdFrFDEQxoNY7Fl98l0Cvgi65yTZ3WQfj0OrUGgf9Dlkk9maYy-5JtlK_3vTXhURkXmYgfnNN8N8hLxisGYg1IedWXNg7Zox8YSsmFKsYW0_PCUrAM4apTickuc57wCEFFI9I6e849CKtluRwybnaL0pPgYaJ7pfyrE-mFIwhUx9oOd3aUNNcPTKpC29xoCZ_vDlO71ZfIhzDEgTZp-LCRbpjLc4P8zNxhZvqbHe0bHWmLx5QU4mM2d8-ZjPyLdPH79uPzcXl-dftpuLxrbQl6ZVQjI7dM45mLqeQ29GNw2OM2PcMPXtODiFDlTXWQfSjMMkgI9iVBO6znXijLw96h5SvFkwF7332eI8m4BxyZr1UggpJYeKvvkL3cUlhXqd5kKwvgbj_6OYVH19s2hZpd4dKZtizgknfUh-b9KdZqDv7dI7o-_t0tWuSr9-1FzGPbrf7C9_KvD-COTaCteY_lj6D72fP3-eMA</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Li, Shaoying</creator><creator>Li, Zhen</creator><creator>Wei, Wan</creator><creator>Ma, Chunyan</creator><creator>Song, Xiaomin</creator><creator>Li, Shufen</creator><creator>He, Wenying</creator><creator>Tian, Jianjun</creator><creator>Huo, Xiaoyan</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150201</creationdate><title>Association of mutation patterns in GyrA and ParC genes with quinolone resistance levels in lactic acid bacteria</title><author>Li, Shaoying ; Li, Zhen ; Wei, Wan ; Ma, Chunyan ; Song, Xiaomin ; Li, Shufen ; He, Wenying ; Tian, Jianjun ; Huo, Xiaoyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-48371c95ddd0f56206abdf9d21aad9f64b9d8ed0855cd07ab9f302b3b8fed5d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>38</topic><topic>38/77</topic><topic>45/23</topic><topic>631/326/22/1434</topic><topic>Acids</topic><topic>Amino Acid Sequence</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacteria</topic><topic>Bacteriology</topic><topic>Biomedical and Life Sciences</topic><topic>Bioorganic Chemistry</topic><topic>Ciprofloxacin - pharmacology</topic><topic>Cultured Milk Products - microbiology</topic><topic>DNA Gyrase - genetics</topic><topic>DNA Topoisomerase IV - genetics</topic><topic>DNA Topoisomerases, Type II - genetics</topic><topic>Drug resistance</topic><topic>Drug Resistance, Bacterial - genetics</topic><topic>Enterococcus - drug effects</topic><topic>Enterococcus - genetics</topic><topic>Enterococcus - isolation & purification</topic><topic>Lactic Acid - metabolism</topic><topic>Lactobacillus - drug effects</topic><topic>Lactobacillus - genetics</topic><topic>Lactobacillus - isolation & purification</topic><topic>Life Sciences</topic><topic>Medicinal Chemistry</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Mutation</topic><topic>Norfloxacin - pharmacology</topic><topic>Organic Chemistry</topic><topic>original-article</topic><topic>Quinolones - pharmacology</topic><topic>Yogurt</topic><topic>Yogurt - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Shaoying</creatorcontrib><creatorcontrib>Li, Zhen</creatorcontrib><creatorcontrib>Wei, Wan</creatorcontrib><creatorcontrib>Ma, Chunyan</creatorcontrib><creatorcontrib>Song, Xiaomin</creatorcontrib><creatorcontrib>Li, Shufen</creatorcontrib><creatorcontrib>He, Wenying</creatorcontrib><creatorcontrib>Tian, Jianjun</creatorcontrib><creatorcontrib>Huo, Xiaoyan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Shaoying</au><au>Li, Zhen</au><au>Wei, Wan</au><au>Ma, Chunyan</au><au>Song, Xiaomin</au><au>Li, Shufen</au><au>He, Wenying</au><au>Tian, Jianjun</au><au>Huo, Xiaoyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of mutation patterns in GyrA and ParC genes with quinolone resistance levels in lactic acid bacteria</atitle><jtitle>Journal of antibiotics</jtitle><stitle>J Antibiot</stitle><addtitle>J Antibiot (Tokyo)</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>68</volume><issue>2</issue><spage>81</spage><epage>87</epage><pages>81-87</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>The quinolone resistance of 19 lactic acid bacterial strains belonging to the genera
Enterococcus
and
Lactobacillus
isolated from the natural fermented koumiss and yoghurt were investigated. The objective of this study was to determine the quinolone resistance levels and to explore the association of the resistance with the mutation patterns in
gyrA
and
parC
genes, as is currently recommended by the Food and Agriculture Organization/World Health Organization Joint Expert Committee in Guidelines for Evaluation of Probiotics in Food for probiotic lactic acid bacteria drug resistance in 2001. The Oxford Cup method and double-tube dilution method were used to determine the quinolone resistance levels of the isolated strains. Generally, all of the 19 strains showed resistance towards norfloxacin and ciprofloxacin when the Oxford cup method was used, whereas the incidence was lower (to norfloxacin 89.5% and to ciprofloxacin 68.4%) when minimum inhibitory concentration breakpoints (CLSI M100-S23) were tested. Furthermore, gene sequencing was conducted on
gyrA
and
parC
of topoisomerase II of these isolated strains. The genetic basis for quinolone resistance may be closely related to mutations in
gyrA
genes as there were 10 mutation sites in amino-acid sequences encoded by
gyrA
genes in 10 quinolone resistance strains and 14 mutation sites in
Enterococcus durans
HZ28, whereas no typical mutations were detected in
parC
genes.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25204345</pmid><doi>10.1038/ja.2014.113</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of antibiotics, 2015-02, Vol.68 (2), p.81-87 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1673377720 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | 38 38/77 45/23 631/326/22/1434 Acids Amino Acid Sequence Anti-Bacterial Agents - pharmacology Bacteria Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Ciprofloxacin - pharmacology Cultured Milk Products - microbiology DNA Gyrase - genetics DNA Topoisomerase IV - genetics DNA Topoisomerases, Type II - genetics Drug resistance Drug Resistance, Bacterial - genetics Enterococcus - drug effects Enterococcus - genetics Enterococcus - isolation & purification Lactic Acid - metabolism Lactobacillus - drug effects Lactobacillus - genetics Lactobacillus - isolation & purification Life Sciences Medicinal Chemistry Microbial Sensitivity Tests Microbiology Mutation Norfloxacin - pharmacology Organic Chemistry original-article Quinolones - pharmacology Yogurt Yogurt - microbiology |
| title | Association of mutation patterns in GyrA and ParC genes with quinolone resistance levels in lactic acid bacteria |
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