Novel arylazopyrazole inhibitors of cyclin-dependent kinases

[Display omitted] Here, we describe new 4-arylazo-3,5-diamino-1H-pyrazole derivatives developed from CAN508, one of the first inhibitors to show preference for transcriptional regulator cyclin-dependent kinase 9. By substituting nitrogen in the pyrazole ring and employing a heteroatom in the 4-aryl...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2015-05, Vol.23 (9), p.1975-1981
Hauptverfasser:	Jorda, Radek, Schütznerová, Eva, Cankař, Petr, Brychtová, Veronika, Navrátilová, Jana, Kryštof, Vladimír
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Cell cycle Cell Proliferation - drug effects Cyclin-dependent kinases Cyclin-Dependent Kinases - antagonists & inhibitors Cyclin-Dependent Kinases - metabolism Dose-Response Relationship, Drug Humans Inhibitor K562 Cells MCF-7 Cells Molecular Structure Protein Kinase Inhibitors - chemical synthesis Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - pharmacology Selectivity Structure-Activity Relationship
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