Influence of dose and animal species on accelerated blood clearance of PEGylated liposomal doxorubicin

[Display omitted] We recently demonstrated that Doxil loses its long-circulating properties when injected repeatedly at doses below 2mg/m2 in dogs. In studies using other animal species, PEGylated liposomal doxorubicin has been reported not to induce the accelerated blood clearance (ABC) phenomenon....

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Veröffentlicht in:	International journal of pharmaceutics 2014-12, Vol.476 (1-2), p.205-212
Hauptverfasser:	Suzuki, Takuya, Ichihara, Masako, Hyodo, Kenji, Yamamoto, Eiichi, Ishida, Tatsuhiro, Kiwada, Hiroshi, Kikuchi, Hiroshi, Ishihara, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Accelerated blood clearance phenomenon Animals Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - pharmacokinetics Dose-Response Relationship, Drug Doxil Doxorubicin Doxorubicin - administration & dosage Doxorubicin - analogs & derivatives Doxorubicin - pharmacokinetics Immunoglobulin M - immunology Macaca fascicularis Male Mice Mice, Inbred BALB C PEGylated liposomes Polyethylene glycol Polyethylene Glycols - administration & dosage Polyethylene Glycols - pharmacokinetics Rats Rats, Wistar Species difference Species Specificity Swine Swine, Miniature
Online-Zugang:	Volltext
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