Evidence of two oxidation states of copper during aggregation of hen egg white lysozyme (HEWL)

In vitro fibrillation of hen egg white lysozyme (HEWL) causes complete reduction of Cu(II) to Cu(I) at pH 7. Here in the present article, we have shown the presence of both Cu(II) and Cu(I) at pH 11 during fibrillation of HEWL using electron paramagnetic resonance and Raman spectroscopy. Our results...

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Veröffentlicht in:	International journal of biological macromolecules 2015-05, Vol.76, p.1-9
Hauptverfasser:	Ghosh, Sudeshna, Pandey, Nitin K., Bhattacharya, Susmita, Roy, Anushree, Nagy, Nóra Veronika, Dasgupta, Swagata
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid - chemistry Animals Copper - chemistry Cu(II) Egg White - chemistry Female Fibrillation Hemolysis Hen egg white lysozyme Hydrogen-Ion Concentration Kinetics Models, Molecular Muramidase - chemistry Nuclear Magnetic Resonance, Biomolecular Oxidation state Oxidation-Reduction Protein Aggregates Protein Aggregation, Pathological Protein Conformation Protein Multimerization Spectrum Analysis, Raman
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