Killer cell immunoglobulin-like receptor (KIR) gene diversity in a population naturally exposed to malaria in Porto Velho, Northern Brazil
Killer cell immunoglobulin‐like receptors (KIR) are expressed mainly in natural killer cells and specifically recognize human leukocyte antigen (HLA) class I molecules. The repertoire of KIR genes and KIR–HLA pairs is known to play a key role in the susceptibilities to and the outcomes of several di...
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| Veröffentlicht in: | Tissue antigens 2015-03, Vol.85 (3), p.190-199 |
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| creator | Perce-da-Silva, D. S. Silva, L. A. Lima-Junior, J. C. Cardoso-Oliveira, J. Ribeiro-Alves, M. Santos, F. Porto, L. C. M. S. Oliveira-Ferreira, J. Banic, D. M. |
| description | Killer cell immunoglobulin‐like receptors (KIR) are expressed mainly in natural killer cells and specifically recognize human leukocyte antigen (HLA) class I molecules. The repertoire of KIR genes and KIR–HLA pairs is known to play a key role in the susceptibilities to and the outcomes of several diseases, including malaria. The aim of this study was to investigate the distribution of KIR genes, KIR genotypes and KIR–HLA pair combinations in a population naturally exposed to malaria from Brazilian Amazon. All 16 KIR genes investigated were present in the studied population. Overall, 46 KIR genotypes were defined. The two most common genotypes in the Porto Velho communities, genotypes 1 and 2, were present at similar frequencies as in the Americas. Principal component analysis based on the frequencies of the KIR genes placed the Porto Velho population closer to the Venezuela Mestizos, USA California hispanic and Brazil Paraná Mixed in terms of KIR gene frequencies. This analysis highlights the multi‐ethnic profile of the Porto Velho population. Most of the individuals were found to have at least one inhibitory KIR–HLA pair. Seventy‐five KIR–HLA pair combinations were identified. The KIR‐2DL2/3_HLA‐C1, KIR3DL1_HLA‐Bw4 and KIR2DL1_HLA‐C2 pairs were the most common. There was no association between KIR genes, KIR genotypes or KIR–HLA pair combinations and malaria susceptibility in the studied population. This is the first report on the distribution of KIR and known HLA ligands in the Porto Velho population. Taken together, these results should provide baseline information that will be relevant to population evolutionary history, malaria and other diseases studies in populations of the Brazilian Amazon. |
| doi_str_mv | 10.1111/tan.12523 |
| format | Article |
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S. ; Silva, L. A. ; Lima-Junior, J. C. ; Cardoso-Oliveira, J. ; Ribeiro-Alves, M. ; Santos, F. ; Porto, L. C. M. S. ; Oliveira-Ferreira, J. ; Banic, D. M.</creator><creatorcontrib>Perce-da-Silva, D. S. ; Silva, L. A. ; Lima-Junior, J. C. ; Cardoso-Oliveira, J. ; Ribeiro-Alves, M. ; Santos, F. ; Porto, L. C. M. S. ; Oliveira-Ferreira, J. ; Banic, D. M.</creatorcontrib><description>Killer cell immunoglobulin‐like receptors (KIR) are expressed mainly in natural killer cells and specifically recognize human leukocyte antigen (HLA) class I molecules. The repertoire of KIR genes and KIR–HLA pairs is known to play a key role in the susceptibilities to and the outcomes of several diseases, including malaria. The aim of this study was to investigate the distribution of KIR genes, KIR genotypes and KIR–HLA pair combinations in a population naturally exposed to malaria from Brazilian Amazon. All 16 KIR genes investigated were present in the studied population. Overall, 46 KIR genotypes were defined. The two most common genotypes in the Porto Velho communities, genotypes 1 and 2, were present at similar frequencies as in the Americas. Principal component analysis based on the frequencies of the KIR genes placed the Porto Velho population closer to the Venezuela Mestizos, USA California hispanic and Brazil Paraná Mixed in terms of KIR gene frequencies. This analysis highlights the multi‐ethnic profile of the Porto Velho population. Most of the individuals were found to have at least one inhibitory KIR–HLA pair. Seventy‐five KIR–HLA pair combinations were identified. The KIR‐2DL2/3_HLA‐C1, KIR3DL1_HLA‐Bw4 and KIR2DL1_HLA‐C2 pairs were the most common. There was no association between KIR genes, KIR genotypes or KIR–HLA pair combinations and malaria susceptibility in the studied population. This is the first report on the distribution of KIR and known HLA ligands in the Porto Velho population. Taken together, these results should provide baseline information that will be relevant to population evolutionary history, malaria and other diseases studies in populations of the Brazilian Amazon.</description><identifier>ISSN: 0001-2815</identifier><identifier>EISSN: 1399-0039</identifier><identifier>DOI: 10.1111/tan.12523</identifier><identifier>PMID: 25656387</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>African Continental Ancestry Group ; Alleles ; Brazil ; Brazil - ethnology ; European Continental Ancestry Group ; Gene Expression ; Gene Frequency ; Genotype ; Hispanic Americans ; HLA Antigens - classification ; HLA Antigens - genetics ; HLA Antigens - immunology ; human leukocyte antigen ; Humans ; killer immunoglobulin-like receptors ; malaria ; Malaria, Falciparum - ethnology ; Malaria, Falciparum - genetics ; Malaria, Falciparum - immunology ; Malaria, Falciparum - parasitology ; Malaria, Vivax - ethnology ; Malaria, Vivax - genetics ; Malaria, Vivax - immunology ; Malaria, Vivax - parasitology ; Plasmodium falciparum - isolation & purification ; Plasmodium vivax - isolation & purification ; Polymorphism, Genetic ; Principal Component Analysis ; Receptors, KIR - classification ; Receptors, KIR - genetics ; Receptors, KIR - immunology</subject><ispartof>Tissue antigens, 2015-03, Vol.85 (3), p.190-199</ispartof><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3963-5b8245d497de04a8210acc64b478054ede8d291d04c732fa1f27a108ae6cad2b3</citedby><cites>FETCH-LOGICAL-c3963-5b8245d497de04a8210acc64b478054ede8d291d04c732fa1f27a108ae6cad2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftan.12523$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftan.12523$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25656387$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perce-da-Silva, D. S.</creatorcontrib><creatorcontrib>Silva, L. A.</creatorcontrib><creatorcontrib>Lima-Junior, J. C.</creatorcontrib><creatorcontrib>Cardoso-Oliveira, J.</creatorcontrib><creatorcontrib>Ribeiro-Alves, M.</creatorcontrib><creatorcontrib>Santos, F.</creatorcontrib><creatorcontrib>Porto, L. C. M. S.</creatorcontrib><creatorcontrib>Oliveira-Ferreira, J.</creatorcontrib><creatorcontrib>Banic, D. M.</creatorcontrib><title>Killer cell immunoglobulin-like receptor (KIR) gene diversity in a population naturally exposed to malaria in Porto Velho, Northern Brazil</title><title>Tissue antigens</title><addtitle>Tissue Antigens</addtitle><description>Killer cell immunoglobulin‐like receptors (KIR) are expressed mainly in natural killer cells and specifically recognize human leukocyte antigen (HLA) class I molecules. The repertoire of KIR genes and KIR–HLA pairs is known to play a key role in the susceptibilities to and the outcomes of several diseases, including malaria. The aim of this study was to investigate the distribution of KIR genes, KIR genotypes and KIR–HLA pair combinations in a population naturally exposed to malaria from Brazilian Amazon. All 16 KIR genes investigated were present in the studied population. Overall, 46 KIR genotypes were defined. The two most common genotypes in the Porto Velho communities, genotypes 1 and 2, were present at similar frequencies as in the Americas. Principal component analysis based on the frequencies of the KIR genes placed the Porto Velho population closer to the Venezuela Mestizos, USA California hispanic and Brazil Paraná Mixed in terms of KIR gene frequencies. This analysis highlights the multi‐ethnic profile of the Porto Velho population. Most of the individuals were found to have at least one inhibitory KIR–HLA pair. Seventy‐five KIR–HLA pair combinations were identified. The KIR‐2DL2/3_HLA‐C1, KIR3DL1_HLA‐Bw4 and KIR2DL1_HLA‐C2 pairs were the most common. There was no association between KIR genes, KIR genotypes or KIR–HLA pair combinations and malaria susceptibility in the studied population. This is the first report on the distribution of KIR and known HLA ligands in the Porto Velho population. Taken together, these results should provide baseline information that will be relevant to population evolutionary history, malaria and other diseases studies in populations of the Brazilian Amazon.</description><subject>African Continental Ancestry Group</subject><subject>Alleles</subject><subject>Brazil</subject><subject>Brazil - ethnology</subject><subject>European Continental Ancestry Group</subject><subject>Gene Expression</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Hispanic Americans</subject><subject>HLA Antigens - classification</subject><subject>HLA Antigens - genetics</subject><subject>HLA Antigens - immunology</subject><subject>human leukocyte antigen</subject><subject>Humans</subject><subject>killer immunoglobulin-like receptors</subject><subject>malaria</subject><subject>Malaria, Falciparum - ethnology</subject><subject>Malaria, Falciparum - genetics</subject><subject>Malaria, Falciparum - immunology</subject><subject>Malaria, Falciparum - parasitology</subject><subject>Malaria, Vivax - ethnology</subject><subject>Malaria, Vivax - genetics</subject><subject>Malaria, Vivax - immunology</subject><subject>Malaria, Vivax - parasitology</subject><subject>Plasmodium falciparum - isolation & purification</subject><subject>Plasmodium vivax - isolation & purification</subject><subject>Polymorphism, Genetic</subject><subject>Principal Component Analysis</subject><subject>Receptors, KIR - classification</subject><subject>Receptors, KIR - genetics</subject><subject>Receptors, KIR - immunology</subject><issn>0001-2815</issn><issn>1399-0039</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS0EokvhwBdAPrYSaf03To5tBUvVaqGwFImLNUlmW1MnDnYCXT4Cn5os2_aGxFxGM_q9Jz09Ql5ydsCnORygO-BCC_mIzLgsy4wxWT4mM8YYz0TB9Q55ltK36VKmLJ-SHaFzncvCzMjvM-c9Rlqj99S17diFKx-q0bsu8-4GacQa-yFEund2-nGfXmGHtHE_MCY3rKnrKNA-9KOHwYWOdjCMEbxfU7ztQ8KGDoG24CE62MAfQpwel-ivw2u6mI5rjB09jvDL-efkyQp8whd3e5d8fvtmefIuO38_Pz05Os9qWeYy01UhlG5UaRpkCgrBGdR1riplCqYVNlg0ouQNU7WRYgV8JQxwVgDmNTSikrtkb-vbx_B9xDTY1qVNfugwjMny3EhptNLmP9BcCS4kkxO6v0XrGFKKuLJ9dC3EteXMblqyU0v2b0sT--rOdqxabB7I-1om4HAL_HQe1_92ssujxb1ltlW4NODtgwLijZ3iGG2_LOb2q1zK-cXFpf0k_wDPrqw_</recordid><startdate>201503</startdate><enddate>201503</enddate><creator>Perce-da-Silva, D. S.</creator><creator>Silva, L. A.</creator><creator>Lima-Junior, J. C.</creator><creator>Cardoso-Oliveira, J.</creator><creator>Ribeiro-Alves, M.</creator><creator>Santos, F.</creator><creator>Porto, L. C. M. S.</creator><creator>Oliveira-Ferreira, J.</creator><creator>Banic, D. 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S.</au><au>Silva, L. A.</au><au>Lima-Junior, J. C.</au><au>Cardoso-Oliveira, J.</au><au>Ribeiro-Alves, M.</au><au>Santos, F.</au><au>Porto, L. C. M. S.</au><au>Oliveira-Ferreira, J.</au><au>Banic, D. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Killer cell immunoglobulin-like receptor (KIR) gene diversity in a population naturally exposed to malaria in Porto Velho, Northern Brazil</atitle><jtitle>Tissue antigens</jtitle><addtitle>Tissue Antigens</addtitle><date>2015-03</date><risdate>2015</risdate><volume>85</volume><issue>3</issue><spage>190</spage><epage>199</epage><pages>190-199</pages><issn>0001-2815</issn><eissn>1399-0039</eissn><abstract>Killer cell immunoglobulin‐like receptors (KIR) are expressed mainly in natural killer cells and specifically recognize human leukocyte antigen (HLA) class I molecules. The repertoire of KIR genes and KIR–HLA pairs is known to play a key role in the susceptibilities to and the outcomes of several diseases, including malaria. The aim of this study was to investigate the distribution of KIR genes, KIR genotypes and KIR–HLA pair combinations in a population naturally exposed to malaria from Brazilian Amazon. All 16 KIR genes investigated were present in the studied population. Overall, 46 KIR genotypes were defined. The two most common genotypes in the Porto Velho communities, genotypes 1 and 2, were present at similar frequencies as in the Americas. Principal component analysis based on the frequencies of the KIR genes placed the Porto Velho population closer to the Venezuela Mestizos, USA California hispanic and Brazil Paraná Mixed in terms of KIR gene frequencies. This analysis highlights the multi‐ethnic profile of the Porto Velho population. Most of the individuals were found to have at least one inhibitory KIR–HLA pair. Seventy‐five KIR–HLA pair combinations were identified. The KIR‐2DL2/3_HLA‐C1, KIR3DL1_HLA‐Bw4 and KIR2DL1_HLA‐C2 pairs were the most common. There was no association between KIR genes, KIR genotypes or KIR–HLA pair combinations and malaria susceptibility in the studied population. This is the first report on the distribution of KIR and known HLA ligands in the Porto Velho population. Taken together, these results should provide baseline information that will be relevant to population evolutionary history, malaria and other diseases studies in populations of the Brazilian Amazon.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>25656387</pmid><doi>10.1111/tan.12523</doi><tpages>10</tpages></addata></record> |
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| ispartof | Tissue antigens, 2015-03, Vol.85 (3), p.190-199 |
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| subjects | African Continental Ancestry Group Alleles Brazil Brazil - ethnology European Continental Ancestry Group Gene Expression Gene Frequency Genotype Hispanic Americans HLA Antigens - classification HLA Antigens - genetics HLA Antigens - immunology human leukocyte antigen Humans killer immunoglobulin-like receptors malaria Malaria, Falciparum - ethnology Malaria, Falciparum - genetics Malaria, Falciparum - immunology Malaria, Falciparum - parasitology Malaria, Vivax - ethnology Malaria, Vivax - genetics Malaria, Vivax - immunology Malaria, Vivax - parasitology Plasmodium falciparum - isolation & purification Plasmodium vivax - isolation & purification Polymorphism, Genetic Principal Component Analysis Receptors, KIR - classification Receptors, KIR - genetics Receptors, KIR - immunology |
| title | Killer cell immunoglobulin-like receptor (KIR) gene diversity in a population naturally exposed to malaria in Porto Velho, Northern Brazil |
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