HU-211, a non-psychotropic cannabinoid, rescues cortical neurones from excitatory amino acid toxicity in culture

The present study examined potential neuroprotective effects of HU-211, a synthetic non-psychotropic cannabinoid with non-competitive NMDA antagonist properties on neurones exposed to various excitotoxins in culture. HU-211 was found to protect neurones from NMDA and quisqualate-induced toxicity but...

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Veröffentlicht in:	Neuroreport 1993-12, Vol.5 (3), p.237-240
Hauptverfasser:	ESHHAR, N, STRIEM, S, BIEGON, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - antagonists & inhibitors Amino Acids - toxicity Animals Biological and medical sciences Cannabinoids - pharmacology Cell Survival - drug effects Cells, Cultured Cerebral Cortex - cytology Dizocilpine Maleate - pharmacokinetics Dronabinol - analogs & derivatives Dronabinol - pharmacology Immunohistochemistry Medical sciences Membranes - drug effects Membranes - metabolism Neurons - drug effects Neuropharmacology Neuroprotective agent Pharmacology. Drug treatments Phosphopyruvate Hydratase - immunology Phosphopyruvate Hydratase - metabolism Radioligand Assay Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
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