Immunohistochemical Study of Mixed Germ Cell Sex Cord Stromal Tumours in 13 Canine Testes
Mixed germ cell sex cord stromal tumours (MGSCTs) are composed of seminiferous tubules, filled with admixed neoplastic Sertoli cells (SCs) and germ cells (GCs). The aim of the present study was to describe 13 canine testicular MGSCTs and to investigate the histochemical features and the immunophenot...
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| Veröffentlicht in: | Journal of comparative pathology 2015-02, Vol.152 (2-3), p.182-187 |
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| creator | Banco, B. Giudice, C. Ghisleni, G. Romussi, S. Behar, D.K. Grieco, V. |
| description | Mixed germ cell sex cord stromal tumours (MGSCTs) are composed of seminiferous tubules, filled with admixed neoplastic Sertoli cells (SCs) and germ cells (GCs). The aim of the present study was to describe 13 canine testicular MGSCTs and to investigate the histochemical features and the immunophenotype of the neoplastic GCs and SCs. Neoplastic SCs were always diffusely labelled for vimentin (VIM), neuron specific enolase (NSE), inhibin (INH)-α and anti-Müllerian hormone (AMH). Cytokeratins AE1/AE3 (CK) and desmin (DES) were expressed in 6/13 and 8/13 cases, respectively. Neoplastic GCs were labelled for placental alkaline phosphatase (PLAP) in 7/13 cases and for CD117 (KIT) in 8/13 cases, while 10 cases were stained uniformly by periodic acid–Schiff (PAS). Immature canine SCs are known to express CK, DES, INH-α and AMH, while immature GCs are stained by PAS and express PLAP and KIT. This GC phenotype also distinguishes between classical and spermatocytic seminoma, with the latter being negative for these markers. The results of the present study show that both neoplastic SCs and GCs in MGSCTs have a de-differentiated phenotype. |
| doi_str_mv | 10.1016/j.jcpa.2014.12.008 |
| format | Article |
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The aim of the present study was to describe 13 canine testicular MGSCTs and to investigate the histochemical features and the immunophenotype of the neoplastic GCs and SCs. Neoplastic SCs were always diffusely labelled for vimentin (VIM), neuron specific enolase (NSE), inhibin (INH)-α and anti-Müllerian hormone (AMH). Cytokeratins AE1/AE3 (CK) and desmin (DES) were expressed in 6/13 and 8/13 cases, respectively. Neoplastic GCs were labelled for placental alkaline phosphatase (PLAP) in 7/13 cases and for CD117 (KIT) in 8/13 cases, while 10 cases were stained uniformly by periodic acid–Schiff (PAS). Immature canine SCs are known to express CK, DES, INH-α and AMH, while immature GCs are stained by PAS and express PLAP and KIT. This GC phenotype also distinguishes between classical and spermatocytic seminoma, with the latter being negative for these markers. The results of the present study show that both neoplastic SCs and GCs in MGSCTs have a de-differentiated phenotype.</description><identifier>ISSN: 0021-9975</identifier><identifier>EISSN: 1532-3129</identifier><identifier>DOI: 10.1016/j.jcpa.2014.12.008</identifier><identifier>PMID: 25670671</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Biomarkers, Tumor - analysis ; dog ; Dog Diseases - pathology ; Dogs ; Immunohistochemistry ; Male ; mixed germ cell sex cord stromal tumour ; Neoplasms, Germ Cell and Embryonal - pathology ; Neoplasms, Germ Cell and Embryonal - veterinary ; Sex Cord-Gonadal Stromal Tumors - pathology ; Sex Cord-Gonadal Stromal Tumors - veterinary ; testes ; Testicular Neoplasms - pathology ; Testicular Neoplasms - veterinary ; Testis - pathology</subject><ispartof>Journal of comparative pathology, 2015-02, Vol.152 (2-3), p.182-187</ispartof><rights>2014 Elsevier Ltd</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-dca4bbe29c6331820213999d7681c86d8acad270775e1d3948594466c7a9ce853</citedby><cites>FETCH-LOGICAL-c470t-dca4bbe29c6331820213999d7681c86d8acad270775e1d3948594466c7a9ce853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jcpa.2014.12.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25670671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Banco, B.</creatorcontrib><creatorcontrib>Giudice, C.</creatorcontrib><creatorcontrib>Ghisleni, G.</creatorcontrib><creatorcontrib>Romussi, S.</creatorcontrib><creatorcontrib>Behar, D.K.</creatorcontrib><creatorcontrib>Grieco, V.</creatorcontrib><title>Immunohistochemical Study of Mixed Germ Cell Sex Cord Stromal Tumours in 13 Canine Testes</title><title>Journal of comparative pathology</title><addtitle>J Comp Pathol</addtitle><description>Mixed germ cell sex cord stromal tumours (MGSCTs) are composed of seminiferous tubules, filled with admixed neoplastic Sertoli cells (SCs) and germ cells (GCs). The aim of the present study was to describe 13 canine testicular MGSCTs and to investigate the histochemical features and the immunophenotype of the neoplastic GCs and SCs. Neoplastic SCs were always diffusely labelled for vimentin (VIM), neuron specific enolase (NSE), inhibin (INH)-α and anti-Müllerian hormone (AMH). Cytokeratins AE1/AE3 (CK) and desmin (DES) were expressed in 6/13 and 8/13 cases, respectively. Neoplastic GCs were labelled for placental alkaline phosphatase (PLAP) in 7/13 cases and for CD117 (KIT) in 8/13 cases, while 10 cases were stained uniformly by periodic acid–Schiff (PAS). Immature canine SCs are known to express CK, DES, INH-α and AMH, while immature GCs are stained by PAS and express PLAP and KIT. This GC phenotype also distinguishes between classical and spermatocytic seminoma, with the latter being negative for these markers. The results of the present study show that both neoplastic SCs and GCs in MGSCTs have a de-differentiated phenotype.</description><subject>Animals</subject><subject>Biomarkers, Tumor - analysis</subject><subject>dog</subject><subject>Dog Diseases - pathology</subject><subject>Dogs</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>mixed germ cell sex cord stromal tumour</subject><subject>Neoplasms, Germ Cell and Embryonal - pathology</subject><subject>Neoplasms, Germ Cell and Embryonal - veterinary</subject><subject>Sex Cord-Gonadal Stromal Tumors - pathology</subject><subject>Sex Cord-Gonadal Stromal Tumors - veterinary</subject><subject>testes</subject><subject>Testicular Neoplasms - pathology</subject><subject>Testicular Neoplasms - veterinary</subject><subject>Testis - pathology</subject><issn>0021-9975</issn><issn>1532-3129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtP7DAQRi10ESyPP0CBXN4mwY_EjiUaFPGSQBQsBZXltWeFV-t4r50g-Pd4tVxKqinmzDczB6EzSmpKqLhY1Su7MTUjtKkpqwnp9tCMtpxVnDL1B80IYbRSSraH6CjnFSlE17IDdMhaIYmQdIZe70OYhvjm8xjtGwRvzRo_j5P7xHGJH_0HOHwLKeAe1qUBH7iPyRUixVDI-RTilDL2A6Yc92bwA-A55BHyCdpfmnWG0-96jF5uruf9XfXwdHvfXz1UtpFkrJw1zWIBTFnBOe1YOZkrpZwUHbWdcJ2xxjFJpGyBOq6arlVNI4SVRlnoWn6M_u5yNyn-m8pqHXy25VozQJyypkJyLhlrZEHZDrUp5pxgqTfJB5M-NSV6q1Sv9Fap3irVlOkirAydf-dPiwDuZ-S_wwJc7gAoX757SDpbD4MF5xPYUbvof8v_Asszhe4</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Banco, B.</creator><creator>Giudice, C.</creator><creator>Ghisleni, G.</creator><creator>Romussi, S.</creator><creator>Behar, D.K.</creator><creator>Grieco, V.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150201</creationdate><title>Immunohistochemical Study of Mixed Germ Cell Sex Cord Stromal Tumours in 13 Canine Testes</title><author>Banco, B. ; Giudice, C. ; Ghisleni, G. ; Romussi, S. ; Behar, D.K. ; Grieco, V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-dca4bbe29c6331820213999d7681c86d8acad270775e1d3948594466c7a9ce853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Biomarkers, Tumor - analysis</topic><topic>dog</topic><topic>Dog Diseases - pathology</topic><topic>Dogs</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>mixed germ cell sex cord stromal tumour</topic><topic>Neoplasms, Germ Cell and Embryonal - pathology</topic><topic>Neoplasms, Germ Cell and Embryonal - veterinary</topic><topic>Sex Cord-Gonadal Stromal Tumors - pathology</topic><topic>Sex Cord-Gonadal Stromal Tumors - veterinary</topic><topic>testes</topic><topic>Testicular Neoplasms - pathology</topic><topic>Testicular Neoplasms - veterinary</topic><topic>Testis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Banco, B.</creatorcontrib><creatorcontrib>Giudice, C.</creatorcontrib><creatorcontrib>Ghisleni, G.</creatorcontrib><creatorcontrib>Romussi, S.</creatorcontrib><creatorcontrib>Behar, D.K.</creatorcontrib><creatorcontrib>Grieco, V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of comparative pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Banco, B.</au><au>Giudice, C.</au><au>Ghisleni, G.</au><au>Romussi, S.</au><au>Behar, D.K.</au><au>Grieco, V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical Study of Mixed Germ Cell Sex Cord Stromal Tumours in 13 Canine Testes</atitle><jtitle>Journal of comparative pathology</jtitle><addtitle>J Comp Pathol</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>152</volume><issue>2-3</issue><spage>182</spage><epage>187</epage><pages>182-187</pages><issn>0021-9975</issn><eissn>1532-3129</eissn><abstract>Mixed germ cell sex cord stromal tumours (MGSCTs) are composed of seminiferous tubules, filled with admixed neoplastic Sertoli cells (SCs) and germ cells (GCs). The aim of the present study was to describe 13 canine testicular MGSCTs and to investigate the histochemical features and the immunophenotype of the neoplastic GCs and SCs. Neoplastic SCs were always diffusely labelled for vimentin (VIM), neuron specific enolase (NSE), inhibin (INH)-α and anti-Müllerian hormone (AMH). Cytokeratins AE1/AE3 (CK) and desmin (DES) were expressed in 6/13 and 8/13 cases, respectively. Neoplastic GCs were labelled for placental alkaline phosphatase (PLAP) in 7/13 cases and for CD117 (KIT) in 8/13 cases, while 10 cases were stained uniformly by periodic acid–Schiff (PAS). Immature canine SCs are known to express CK, DES, INH-α and AMH, while immature GCs are stained by PAS and express PLAP and KIT. This GC phenotype also distinguishes between classical and spermatocytic seminoma, with the latter being negative for these markers. 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| subjects | Animals Biomarkers, Tumor - analysis dog Dog Diseases - pathology Dogs Immunohistochemistry Male mixed germ cell sex cord stromal tumour Neoplasms, Germ Cell and Embryonal - pathology Neoplasms, Germ Cell and Embryonal - veterinary Sex Cord-Gonadal Stromal Tumors - pathology Sex Cord-Gonadal Stromal Tumors - veterinary testes Testicular Neoplasms - pathology Testicular Neoplasms - veterinary Testis - pathology |
| title | Immunohistochemical Study of Mixed Germ Cell Sex Cord Stromal Tumours in 13 Canine Testes |
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