Frequency discrimination in rats exposed to noise as juveniles
Abstract Sound exposure during the early postnatal period can significantly influence the function of the auditory system in rats during adulthood. In the present study, rat pups (strain Long–Evans) were exposed to broad-band noise at 125 dB SPL for 8, 12 or 25 min on postnatal day 14 and then at th...
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| Veröffentlicht in: | Physiology & behavior 2015-05, Vol.144, p.60-65 |
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| creator | Šuta, Daniel Rybalko, Natalia Shen, Da-Wei Popelář, Jiří Poon, Paul W.F Syka, Josef |
| description | Abstract Sound exposure during the early postnatal period can significantly influence the function of the auditory system in rats during adulthood. In the present study, rat pups (strain Long–Evans) were exposed to broad-band noise at 125 dB SPL for 8, 12 or 25 min on postnatal day 14 and then at the age of 3–5 months their frequency discrimination at 4 and 16 kHz was assessed using a modified method of the prepulse inhibition of the acoustic startle reflex. In all groups of exposed rats, an altered frequency discrimination of the tonal stimuli was observed, in comparison with controls, at 70 dB SPL. A worsening of frequency discrimination was observed even in animals exposed for 8 min, the auditory thresholds of which were almost identical to that of control animals. The individual auditory thresholds did not correlate with frequency discrimination. The difference in frequency discrimination between the exposed and control animals disappeared at 85–90 dB SPL. Our data suggests that brief noise exposure during the critical period of development results in the altered frequency discrimination at moderate sound intensities in adult rats, which may appear even in individuals with normal hearing thresholds. |
| doi_str_mv | 10.1016/j.physbeh.2015.03.005 |
| format | Article |
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In the present study, rat pups (strain Long–Evans) were exposed to broad-band noise at 125 dB SPL for 8, 12 or 25 min on postnatal day 14 and then at the age of 3–5 months their frequency discrimination at 4 and 16 kHz was assessed using a modified method of the prepulse inhibition of the acoustic startle reflex. In all groups of exposed rats, an altered frequency discrimination of the tonal stimuli was observed, in comparison with controls, at 70 dB SPL. A worsening of frequency discrimination was observed even in animals exposed for 8 min, the auditory thresholds of which were almost identical to that of control animals. The individual auditory thresholds did not correlate with frequency discrimination. The difference in frequency discrimination between the exposed and control animals disappeared at 85–90 dB SPL. Our data suggests that brief noise exposure during the critical period of development results in the altered frequency discrimination at moderate sound intensities in adult rats, which may appear even in individuals with normal hearing thresholds.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/j.physbeh.2015.03.005</identifier><identifier>PMID: 25747769</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acoustic Stimulation ; Analysis of Variance ; Animals ; Animals, Newborn ; Auditory system ; Auditory Threshold - physiology ; Behavioral ; Critical period ; Development ; Electroencephalography ; Evoked Potentials, Auditory, Brain Stem - physiology ; Female ; Male ; Noise ; Noise exposure ; Prepulse inhibition ; Prepulse Inhibition - physiology ; Psychiatry ; Psychoacoustics ; Rats ; Rats, Long-Evans ; Reflex, Startle - physiology ; Startle reflex ; Time Factors</subject><ispartof>Physiology & behavior, 2015-05, Vol.144, p.60-65</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-9c52ded453ace2bdef8a85c5e3611556032743dbbf287ca048dfd2f35ccb19b33</citedby><cites>FETCH-LOGICAL-c420t-9c52ded453ace2bdef8a85c5e3611556032743dbbf287ca048dfd2f35ccb19b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0031938415001328$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25747769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Šuta, Daniel</creatorcontrib><creatorcontrib>Rybalko, Natalia</creatorcontrib><creatorcontrib>Shen, Da-Wei</creatorcontrib><creatorcontrib>Popelář, Jiří</creatorcontrib><creatorcontrib>Poon, Paul W.F</creatorcontrib><creatorcontrib>Syka, Josef</creatorcontrib><title>Frequency discrimination in rats exposed to noise as juveniles</title><title>Physiology & behavior</title><addtitle>Physiol Behav</addtitle><description>Abstract Sound exposure during the early postnatal period can significantly influence the function of the auditory system in rats during adulthood. In the present study, rat pups (strain Long–Evans) were exposed to broad-band noise at 125 dB SPL for 8, 12 or 25 min on postnatal day 14 and then at the age of 3–5 months their frequency discrimination at 4 and 16 kHz was assessed using a modified method of the prepulse inhibition of the acoustic startle reflex. In all groups of exposed rats, an altered frequency discrimination of the tonal stimuli was observed, in comparison with controls, at 70 dB SPL. A worsening of frequency discrimination was observed even in animals exposed for 8 min, the auditory thresholds of which were almost identical to that of control animals. The individual auditory thresholds did not correlate with frequency discrimination. The difference in frequency discrimination between the exposed and control animals disappeared at 85–90 dB SPL. Our data suggests that brief noise exposure during the critical period of development results in the altered frequency discrimination at moderate sound intensities in adult rats, which may appear even in individuals with normal hearing thresholds.</description><subject>Acoustic Stimulation</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Auditory system</subject><subject>Auditory Threshold - physiology</subject><subject>Behavioral</subject><subject>Critical period</subject><subject>Development</subject><subject>Electroencephalography</subject><subject>Evoked Potentials, Auditory, Brain Stem - physiology</subject><subject>Female</subject><subject>Male</subject><subject>Noise</subject><subject>Noise exposure</subject><subject>Prepulse inhibition</subject><subject>Prepulse Inhibition - physiology</subject><subject>Psychiatry</subject><subject>Psychoacoustics</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>Reflex, Startle - physiology</subject><subject>Startle reflex</subject><subject>Time Factors</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS0EotvCRwDlyCVh7Inj5FKEKkqRKvVAK3GzHHuiOmTjxU4q9tvj1S4cuHQuc3nz5_0eY-84VBx483Gsdo_71NNjJYDLCrACkC_YhrcKSwnqx0u2AUBedtjWZ-w8pRFyYY2v2ZmQqlaq6Tbs8jrSr5Vmuy-cTzb6rZ_N4sNc-LmIZkkF_d6FRK5YQjEHn6gwqRjXJ5r9ROkNezWYKdHbU79gD9df7q9uytu7r9-uPt-WthawlJ2VwpGrJRpLonc0tKaVVhI2nEvZAApVo-v7QbTKGqhbNzgxoLS2512PeME-HPfuYsjvpkVv87c0TWamsCbNG4WouKq7LJVHqY0hpUiD3mVXJu41B31Ap0d9QqcP6DSgzujy3PvTibXfkvs39ZdVFnw6CigbffIUdbI-kyPnI9lFu-CfPXH53wY7-dlbM_2kPaUxrHHOFDXXSWjQ3w_5HeLjEoCjaPEP2YiXzg</recordid><startdate>20150515</startdate><enddate>20150515</enddate><creator>Šuta, Daniel</creator><creator>Rybalko, Natalia</creator><creator>Shen, Da-Wei</creator><creator>Popelář, Jiří</creator><creator>Poon, Paul W.F</creator><creator>Syka, Josef</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150515</creationdate><title>Frequency discrimination in rats exposed to noise as juveniles</title><author>Šuta, Daniel ; Rybalko, Natalia ; Shen, Da-Wei ; Popelář, Jiří ; Poon, Paul W.F ; Syka, Josef</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-9c52ded453ace2bdef8a85c5e3611556032743dbbf287ca048dfd2f35ccb19b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acoustic Stimulation</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Auditory system</topic><topic>Auditory Threshold - physiology</topic><topic>Behavioral</topic><topic>Critical period</topic><topic>Development</topic><topic>Electroencephalography</topic><topic>Evoked Potentials, Auditory, Brain Stem - physiology</topic><topic>Female</topic><topic>Male</topic><topic>Noise</topic><topic>Noise exposure</topic><topic>Prepulse inhibition</topic><topic>Prepulse Inhibition - physiology</topic><topic>Psychiatry</topic><topic>Psychoacoustics</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>Reflex, Startle - physiology</topic><topic>Startle reflex</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Šuta, Daniel</creatorcontrib><creatorcontrib>Rybalko, Natalia</creatorcontrib><creatorcontrib>Shen, Da-Wei</creatorcontrib><creatorcontrib>Popelář, Jiří</creatorcontrib><creatorcontrib>Poon, Paul W.F</creatorcontrib><creatorcontrib>Syka, Josef</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Šuta, Daniel</au><au>Rybalko, Natalia</au><au>Shen, Da-Wei</au><au>Popelář, Jiří</au><au>Poon, Paul W.F</au><au>Syka, Josef</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frequency discrimination in rats exposed to noise as juveniles</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>2015-05-15</date><risdate>2015</risdate><volume>144</volume><spage>60</spage><epage>65</epage><pages>60-65</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>Abstract Sound exposure during the early postnatal period can significantly influence the function of the auditory system in rats during adulthood. In the present study, rat pups (strain Long–Evans) were exposed to broad-band noise at 125 dB SPL for 8, 12 or 25 min on postnatal day 14 and then at the age of 3–5 months their frequency discrimination at 4 and 16 kHz was assessed using a modified method of the prepulse inhibition of the acoustic startle reflex. In all groups of exposed rats, an altered frequency discrimination of the tonal stimuli was observed, in comparison with controls, at 70 dB SPL. A worsening of frequency discrimination was observed even in animals exposed for 8 min, the auditory thresholds of which were almost identical to that of control animals. The individual auditory thresholds did not correlate with frequency discrimination. The difference in frequency discrimination between the exposed and control animals disappeared at 85–90 dB SPL. Our data suggests that brief noise exposure during the critical period of development results in the altered frequency discrimination at moderate sound intensities in adult rats, which may appear even in individuals with normal hearing thresholds.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25747769</pmid><doi>10.1016/j.physbeh.2015.03.005</doi><tpages>6</tpages></addata></record> |
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| subjects | Acoustic Stimulation Analysis of Variance Animals Animals, Newborn Auditory system Auditory Threshold - physiology Behavioral Critical period Development Electroencephalography Evoked Potentials, Auditory, Brain Stem - physiology Female Male Noise Noise exposure Prepulse inhibition Prepulse Inhibition - physiology Psychiatry Psychoacoustics Rats Rats, Long-Evans Reflex, Startle - physiology Startle reflex Time Factors |
| title | Frequency discrimination in rats exposed to noise as juveniles |
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