Induction of hepatic drug metabolizing enzymes and interaction with carbon tetrachloride in rats after a single oral exposure to atrazine

A single oral dose (430 mg/kg) of atrazine, a widely employed s-triazine herbicide, was administered to young male rats. There was a significant increase of the in vivo elimination ofhexobarbital and a significant induction of the activity of 7-pentoxyresorufin-O-dealkylase, while cytochrome P-450 c...

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Veröffentlicht in:	Toxicology letters 1993-09, Vol.69 (3), p.279-288
Hauptverfasser:	Ugazio, Giancarlo, Burdino, Elisa, Dacasto, Mauro, Bosio, Anita, van't Klooster, Gerben, Nebbia, Carlo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrazine Atrazine - metabolism Atrazine - toxicity Carbon tetrachloride Carbon Tetrachloride - toxicity Cytochrome P-450 CYP1A1 Cytochrome P-450 CYP2B1 Cytochrome P-450 Enzyme System - biosynthesis Enzyme Induction - drug effects Glutathione - metabolism Herbicide Induction Liver - drug effects Liver - metabolism Male Oxidoreductases - biosynthesis Phenobarbital - pharmacology Rats Rats, Wistar Xenobiotic metabolizing enzyme
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