Analysis of Somatic Hypermutation in Mouse Peyer's Patches Using Immunoglobulin κ Light-Chain Transgenes

We have exploited mice transgenic for an immunoglobulin κ light chain in order to show that immunoglobulin genes in the B cells of Peyer's patches in unimmunized mice carry a high level of somatic mutations. Most of the mutations are found in the subpopulation of B cells which, based on peanut...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-11, Vol.90 (21), p.9862-9866
Hauptverfasser:	Gonzalez-Fernandez, Africa, Milstein, Cesar
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antigens B lymphocytes B-Lymphocytes - immunology Base Sequence Biological and medical sciences DNA - chemistry DNA - isolation & purification Flow Cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Genes, Immunoglobulin Genetic mutation Immunobiology Immunoglobulin kappa-Chains - genetics Immunoglobulin Light Chains - genetics Immunoglobulin Variable Region - genetics Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Lymphoid tissue Mice Mice, Transgenic Molecular Sequence Data Oligonucleotide Probes Peyer's Patches - immunology Peyers patches Point Mutation Polymerase Chain Reaction Somatic mutation Spleen Transgenes Transgenic animals
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