Influence of Fluorination on Protein-Engineered Coiled-Coil Fibers

We describe the design and characterization of fluorinated coiled-coil proteins able to assemble into robust nano- and microfibers. Fluorination is achieved biosynthetically by residue-specific incorporation of 5,5,5-trifluoroleucine (TFL). The fluorinated proteins C+TFL and Q+TFL are highly α-helic...

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Veröffentlicht in:	Biomacromolecules 2015-04, Vol.16 (4), p.1210-1217
Hauptverfasser:	More, Haresh T, Zhang, Kevin S, Srivastava, Nikita, Frezzo, Joseph A, Montclare, Jin K
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Cartilage Oligomeric Matrix Protein - chemistry Cartilage Oligomeric Matrix Protein - metabolism Curcumin - chemistry Halogenation Leucine - analogs & derivatives Leucine - chemistry Molecular Sequence Data Osmolar Concentration Protein Aggregates Protein Binding Protein Stability Protein Structure, Tertiary Zinc - chemistry
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