Intestinal Microbiota Development in Preterm Neonates and Effect of Perinatal Antibiotics
Objectives To assess the establishment of the intestinal microbiota in very low birthweight preterm infants and to evaluate the impact of perinatal factors, such as delivery mode and perinatal antibiotics. Study design We used 16S ribosomal RNA gene sequence-based microbiota analysis and quantitativ...
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| Veröffentlicht in: | The Journal of pediatrics 2015-03, Vol.166 (3), p.538-544 |
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| creator | Arboleya, Silvia, MSc Sánchez, Borja, PhD Milani, Christian, MSc Duranti, Sabrina, MSc Solís, Gonzalo, PhD Fernández, Nuria, PhD de los Reyes-Gavilán, Clara G., PhD Ventura, Marco, PhD Margolles, Abelardo, PhD Gueimonde, Miguel, PhD |
| description | Objectives To assess the establishment of the intestinal microbiota in very low birthweight preterm infants and to evaluate the impact of perinatal factors, such as delivery mode and perinatal antibiotics. Study design We used 16S ribosomal RNA gene sequence-based microbiota analysis and quantitative polymerase chain reaction to evaluate the establishment of the intestinal microbiota. We also evaluated factors affecting the microbiota, during the first 3 months of life in preterm infants (n = 27) compared with full-term babies (n = 13). Results Immaturity affects the microbiota as indicated by a reduced percentage of the family Bacteroidaceae during the first months of life and by a higher initial percentage of Lactobacillaceae in preterm infants compared with full term infants. Perinatal antibiotics, including intrapartum antimicrobial prophylaxis, affects the gut microbiota, as indicated by increased Enterobacteriaceae family organisms in the infants. Conclusions Prematurity and perinatal antibiotic administration strongly affect the initial establishment of microbiota with potential consequences for later health. |
| doi_str_mv | 10.1016/j.jpeds.2014.09.041 |
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Study design We used 16S ribosomal RNA gene sequence-based microbiota analysis and quantitative polymerase chain reaction to evaluate the establishment of the intestinal microbiota. We also evaluated factors affecting the microbiota, during the first 3 months of life in preterm infants (n = 27) compared with full-term babies (n = 13). Results Immaturity affects the microbiota as indicated by a reduced percentage of the family Bacteroidaceae during the first months of life and by a higher initial percentage of Lactobacillaceae in preterm infants compared with full term infants. Perinatal antibiotics, including intrapartum antimicrobial prophylaxis, affects the gut microbiota, as indicated by increased Enterobacteriaceae family organisms in the infants. Conclusions Prematurity and perinatal antibiotic administration strongly affect the initial establishment of microbiota with potential consequences for later health.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2014.09.041</identifier><identifier>PMID: 25444008</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Anti-Bacterial Agents - pharmacology ; Female ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases - genetics ; Infant, Premature, Diseases - microbiology ; Intestines - microbiology ; Male ; Microbiota - drug effects ; Microbiota - genetics ; Pediatrics ; Polymerase Chain Reaction ; RNA, Ribosomal, 16S - genetics</subject><ispartof>The Journal of pediatrics, 2015-03, Vol.166 (3), p.538-544</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-fe888ddd31374b42f808302692ba057a504a150bb5631dc2d37658ebc15cf78c3</citedby><cites>FETCH-LOGICAL-c459t-fe888ddd31374b42f808302692ba057a504a150bb5631dc2d37658ebc15cf78c3</cites><orcidid>0000-0002-0192-901X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpeds.2014.09.041$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25444008$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arboleya, Silvia, MSc</creatorcontrib><creatorcontrib>Sánchez, Borja, PhD</creatorcontrib><creatorcontrib>Milani, Christian, MSc</creatorcontrib><creatorcontrib>Duranti, Sabrina, MSc</creatorcontrib><creatorcontrib>Solís, Gonzalo, PhD</creatorcontrib><creatorcontrib>Fernández, Nuria, PhD</creatorcontrib><creatorcontrib>de los Reyes-Gavilán, Clara G., PhD</creatorcontrib><creatorcontrib>Ventura, Marco, PhD</creatorcontrib><creatorcontrib>Margolles, Abelardo, PhD</creatorcontrib><creatorcontrib>Gueimonde, Miguel, PhD</creatorcontrib><title>Intestinal Microbiota Development in Preterm Neonates and Effect of Perinatal Antibiotics</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Objectives To assess the establishment of the intestinal microbiota in very low birthweight preterm infants and to evaluate the impact of perinatal factors, such as delivery mode and perinatal antibiotics. Study design We used 16S ribosomal RNA gene sequence-based microbiota analysis and quantitative polymerase chain reaction to evaluate the establishment of the intestinal microbiota. We also evaluated factors affecting the microbiota, during the first 3 months of life in preterm infants (n = 27) compared with full-term babies (n = 13). Results Immaturity affects the microbiota as indicated by a reduced percentage of the family Bacteroidaceae during the first months of life and by a higher initial percentage of Lactobacillaceae in preterm infants compared with full term infants. Perinatal antibiotics, including intrapartum antimicrobial prophylaxis, affects the gut microbiota, as indicated by increased Enterobacteriaceae family organisms in the infants. Conclusions Prematurity and perinatal antibiotic administration strongly affect the initial establishment of microbiota with potential consequences for later health.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Premature, Diseases - genetics</subject><subject>Infant, Premature, Diseases - microbiology</subject><subject>Intestines - microbiology</subject><subject>Male</subject><subject>Microbiota - drug effects</subject><subject>Microbiota - genetics</subject><subject>Pediatrics</subject><subject>Polymerase Chain Reaction</subject><subject>RNA, Ribosomal, 16S - genetics</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1TAUhC0EoreFJ0BCWbJJevyTOFmAVJXSViptJWDFwnLsE8khcS62b6W-TZ-lT4bDLSzYsLIXM3M03xDyhkJFgTbHYzVu0caKARUVdBUI-oxsKHSybFrOn5MNAGMlF7I5IIcxjgDQCYCX5IDVQuRfuyHfL33CmJzXU_HZmbD0bkm6-Ih3OC3bGX0qnC9uAyYMc3GNi9dZX2hvi7NhQJMeH5bh8eEWQ45IOeTEJ7dmOBNfkReDniK-fnqPyLdPZ19PL8qrm_PL05Or0oi6S-WAbdtaaznlUvSCDS20HFjTsV5DLXUNQtMa-r5uOLWGWS6busXe0NoMsjX8iLzb527D8nOX26jZRYPTpD0uu6hoIzlIKbjMUr6X5qYxBhzUNrhZh3tFQa1U1ah-U1UrVQWdylSz6-3TgV0_o_3r-YMxC97vBZhr3jkMKhqH3qB1ITNSdnH_OfDhH7-ZnHdGTz_wHuO47EIeKDdRkSlQX9Zh113per1jwH8BO8-gBQ</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Arboleya, Silvia, MSc</creator><creator>Sánchez, Borja, PhD</creator><creator>Milani, Christian, MSc</creator><creator>Duranti, Sabrina, MSc</creator><creator>Solís, Gonzalo, PhD</creator><creator>Fernández, Nuria, PhD</creator><creator>de los Reyes-Gavilán, Clara G., PhD</creator><creator>Ventura, Marco, PhD</creator><creator>Margolles, Abelardo, PhD</creator><creator>Gueimonde, Miguel, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0192-901X</orcidid></search><sort><creationdate>20150301</creationdate><title>Intestinal Microbiota Development in Preterm Neonates and Effect of Perinatal Antibiotics</title><author>Arboleya, Silvia, MSc ; Sánchez, Borja, PhD ; Milani, Christian, MSc ; Duranti, Sabrina, MSc ; Solís, Gonzalo, PhD ; Fernández, Nuria, PhD ; de los Reyes-Gavilán, Clara G., PhD ; Ventura, Marco, PhD ; Margolles, Abelardo, PhD ; Gueimonde, Miguel, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-fe888ddd31374b42f808302692ba057a504a150bb5631dc2d37658ebc15cf78c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Premature, Diseases - genetics</topic><topic>Infant, Premature, Diseases - microbiology</topic><topic>Intestines - microbiology</topic><topic>Male</topic><topic>Microbiota - drug effects</topic><topic>Microbiota - genetics</topic><topic>Pediatrics</topic><topic>Polymerase Chain Reaction</topic><topic>RNA, Ribosomal, 16S - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arboleya, Silvia, MSc</creatorcontrib><creatorcontrib>Sánchez, Borja, PhD</creatorcontrib><creatorcontrib>Milani, Christian, MSc</creatorcontrib><creatorcontrib>Duranti, Sabrina, MSc</creatorcontrib><creatorcontrib>Solís, Gonzalo, PhD</creatorcontrib><creatorcontrib>Fernández, Nuria, PhD</creatorcontrib><creatorcontrib>de los Reyes-Gavilán, Clara G., PhD</creatorcontrib><creatorcontrib>Ventura, Marco, PhD</creatorcontrib><creatorcontrib>Margolles, Abelardo, PhD</creatorcontrib><creatorcontrib>Gueimonde, Miguel, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arboleya, Silvia, MSc</au><au>Sánchez, Borja, PhD</au><au>Milani, Christian, MSc</au><au>Duranti, Sabrina, MSc</au><au>Solís, Gonzalo, PhD</au><au>Fernández, Nuria, PhD</au><au>de los Reyes-Gavilán, Clara G., PhD</au><au>Ventura, Marco, PhD</au><au>Margolles, Abelardo, PhD</au><au>Gueimonde, Miguel, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intestinal Microbiota Development in Preterm Neonates and Effect of Perinatal Antibiotics</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>166</volume><issue>3</issue><spage>538</spage><epage>544</epage><pages>538-544</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>Objectives To assess the establishment of the intestinal microbiota in very low birthweight preterm infants and to evaluate the impact of perinatal factors, such as delivery mode and perinatal antibiotics. Study design We used 16S ribosomal RNA gene sequence-based microbiota analysis and quantitative polymerase chain reaction to evaluate the establishment of the intestinal microbiota. We also evaluated factors affecting the microbiota, during the first 3 months of life in preterm infants (n = 27) compared with full-term babies (n = 13). Results Immaturity affects the microbiota as indicated by a reduced percentage of the family Bacteroidaceae during the first months of life and by a higher initial percentage of Lactobacillaceae in preterm infants compared with full term infants. Perinatal antibiotics, including intrapartum antimicrobial prophylaxis, affects the gut microbiota, as indicated by increased Enterobacteriaceae family organisms in the infants. Conclusions Prematurity and perinatal antibiotic administration strongly affect the initial establishment of microbiota with potential consequences for later health.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25444008</pmid><doi>10.1016/j.jpeds.2014.09.041</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0192-901X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Anti-Bacterial Agents - pharmacology Female Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases - genetics Infant, Premature, Diseases - microbiology Intestines - microbiology Male Microbiota - drug effects Microbiota - genetics Pediatrics Polymerase Chain Reaction RNA, Ribosomal, 16S - genetics |
| title | Intestinal Microbiota Development in Preterm Neonates and Effect of Perinatal Antibiotics |
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