Reliability of risk-based screening for hepatitis C virus infection among pregnant women in Egypt
Summary Objectives The Centers for Disease Control and Prevention (CDC) only recommends risk-based HCV screening for pregnant women in the United States. This study sought to determine the reliability of risk-based versus universal HCV screening for pregnant women in Egypt, a country with the world&...
Gespeichert in:
| Veröffentlicht in: | The Journal of infection 2015-05, Vol.70 (5), p.512-519 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 519 |
|---|---|
| container_issue | 5 |
| container_start_page | 512 |
| container_title | The Journal of infection |
| container_volume | 70 |
| creator | El-Kamary, Samer S Hashem, Mohamed Saleh, Doa'a A Ehab, Mohamed Sharaf, Sahar A El-Mougy, Fatma Abdelsalam, Lobna Jhaveri, Ravi Aboulnasr, Ahmed El-Ghazaly, Hesham |
| description | Summary Objectives The Centers for Disease Control and Prevention (CDC) only recommends risk-based HCV screening for pregnant women in the United States. This study sought to determine the reliability of risk-based versus universal HCV screening for pregnant women in Egypt, a country with the world's highest HCV prevalence that also relies on risk-based screening, and to identify additional characteristics that could increase the reliability of risk-based screening. Methods Pregnant women attending the Cairo University antenatal clinic were tested for anti-HCV antibodies and RNA, and demographic characteristics and risk factors for infection were assessed. Results All 1250 pregnant women approached agreed to participate (100%) with a mean age of 27.4 ± 5.5 years (range:16–45). HCV antibodies and RNA were positive in 52 (4.2%) and 30 (2.4%) women respectively. After adjustment, only age (OR:1.08, 95%CI:1.002–1.16, p |
| doi_str_mv | 10.1016/j.jinf.2015.01.009 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1673073367</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0163445315000304</els_id><sourcerecordid>1673073367</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-a5b23b10e3ef8e9bcd886078aa5f4829e775495e2c9e437cf524d0f13e3d04be3</originalsourceid><addsrcrecordid>eNp9kUtv1DAURi0EosPAH2CBvGST4GceEkJCo_KQKiG1sLYc53pwmtjBTlrNv8fRFBZddHUX99zP8vkQektJSQmtPgzl4LwtGaGyJLQkpH2GdlRyVrBasOdolyFeCCH5BXqV0kAywdvqJbpgsmKc1tUO6WsYne7c6JYTDhZHl26LTifocTIRwDt_xDZE_BtmvbjFJXzAdy6uCee3wSwueKynkKk5wtFrv-D7MIHPa3x5PM3La_TC6jHBm4e5R7--XP48fCuufnz9fvh8VRjR0KXQsmO8owQ42AbazvRNU5G60Vpa0bAW6lqKVgIzLQheGyuZ6ImlHHhPRAd8j96fc-cY_qyQFjW5ZGActYewJkWrmpOa8zz2iJ1RE0NKEayao5t0PClK1KZWDWpTqza1ilC1idujdw_5azdB___kn8sMfDwDkH955yCqZBx4A72LWZTqg3s6_9OjczM674web-EEaQhr9NmfoioxRdTNVu7WLZW5V04E_wuMLp_i</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1673073367</pqid></control><display><type>article</type><title>Reliability of risk-based screening for hepatitis C virus infection among pregnant women in Egypt</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>El-Kamary, Samer S ; Hashem, Mohamed ; Saleh, Doa'a A ; Ehab, Mohamed ; Sharaf, Sahar A ; El-Mougy, Fatma ; Abdelsalam, Lobna ; Jhaveri, Ravi ; Aboulnasr, Ahmed ; El-Ghazaly, Hesham</creator><creatorcontrib>El-Kamary, Samer S ; Hashem, Mohamed ; Saleh, Doa'a A ; Ehab, Mohamed ; Sharaf, Sahar A ; El-Mougy, Fatma ; Abdelsalam, Lobna ; Jhaveri, Ravi ; Aboulnasr, Ahmed ; El-Ghazaly, Hesham</creatorcontrib><description>Summary Objectives The Centers for Disease Control and Prevention (CDC) only recommends risk-based HCV screening for pregnant women in the United States. This study sought to determine the reliability of risk-based versus universal HCV screening for pregnant women in Egypt, a country with the world's highest HCV prevalence that also relies on risk-based screening, and to identify additional characteristics that could increase the reliability of risk-based screening. Methods Pregnant women attending the Cairo University antenatal clinic were tested for anti-HCV antibodies and RNA, and demographic characteristics and risk factors for infection were assessed. Results All 1250 pregnant women approached agreed to participate (100%) with a mean age of 27.4 ± 5.5 years (range:16–45). HCV antibodies and RNA were positive in 52 (4.2%) and 30 (2.4%) women respectively. After adjustment, only age (OR:1.08, 95%CI:1.002–1.16, p < 0.01 ), history of prior pregnancies (OR:1.20, 95%CI:1.01–1.43, p < 0.04 ), and working in the healthcare sector (OR:8.68, 95%CI:1.72–43.62, p < 0.01 ), remained significantly associated with chronic HCV infection. Conclusions Universal antenatal HCV screening was widely accepted (100%) and traditional risk-based screening alone would have missed 3 (10%) chronically infected women, thereby supporting universal screening of pregnant women whenever possible. Otherwise, risk-based screening should be modified to include history of prior pregnancy and healthcare employment.</description><identifier>ISSN: 0163-4453</identifier><identifier>EISSN: 1532-2742</identifier><identifier>DOI: 10.1016/j.jinf.2015.01.009</identifier><identifier>PMID: 25623176</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Cross-Sectional Studies ; Egypt ; Egypt - epidemiology ; Female ; Hepacivirus - genetics ; Hepacivirus - isolation & purification ; Hepatitis C ; Hepatitis C - diagnosis ; Hepatitis C - epidemiology ; Hepatitis C Antibodies - blood ; Hepatitis C, Chronic - diagnosis ; Hepatitis C, Chronic - epidemiology ; Humans ; Infectious Disease ; Mass Screening ; Middle Aged ; Pregnancy ; Pregnancy Complications, Infectious - diagnosis ; Pregnancy Complications, Infectious - epidemiology ; Prevalence ; Reproducibility of Results ; Risk Factors ; Young Adult</subject><ispartof>The Journal of infection, 2015-05, Vol.70 (5), p.512-519</ispartof><rights>The British Infection Association</rights><rights>2015 The British Infection Association</rights><rights>Copyright © 2015 The British Infection Association. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-a5b23b10e3ef8e9bcd886078aa5f4829e775495e2c9e437cf524d0f13e3d04be3</citedby><cites>FETCH-LOGICAL-c481t-a5b23b10e3ef8e9bcd886078aa5f4829e775495e2c9e437cf524d0f13e3d04be3</cites><orcidid>0000-0002-1137-7079 ; 0000-0001-9921-0419</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0163445315000304$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25623176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Kamary, Samer S</creatorcontrib><creatorcontrib>Hashem, Mohamed</creatorcontrib><creatorcontrib>Saleh, Doa'a A</creatorcontrib><creatorcontrib>Ehab, Mohamed</creatorcontrib><creatorcontrib>Sharaf, Sahar A</creatorcontrib><creatorcontrib>El-Mougy, Fatma</creatorcontrib><creatorcontrib>Abdelsalam, Lobna</creatorcontrib><creatorcontrib>Jhaveri, Ravi</creatorcontrib><creatorcontrib>Aboulnasr, Ahmed</creatorcontrib><creatorcontrib>El-Ghazaly, Hesham</creatorcontrib><title>Reliability of risk-based screening for hepatitis C virus infection among pregnant women in Egypt</title><title>The Journal of infection</title><addtitle>J Infect</addtitle><description>Summary Objectives The Centers for Disease Control and Prevention (CDC) only recommends risk-based HCV screening for pregnant women in the United States. This study sought to determine the reliability of risk-based versus universal HCV screening for pregnant women in Egypt, a country with the world's highest HCV prevalence that also relies on risk-based screening, and to identify additional characteristics that could increase the reliability of risk-based screening. Methods Pregnant women attending the Cairo University antenatal clinic were tested for anti-HCV antibodies and RNA, and demographic characteristics and risk factors for infection were assessed. Results All 1250 pregnant women approached agreed to participate (100%) with a mean age of 27.4 ± 5.5 years (range:16–45). HCV antibodies and RNA were positive in 52 (4.2%) and 30 (2.4%) women respectively. After adjustment, only age (OR:1.08, 95%CI:1.002–1.16, p < 0.01 ), history of prior pregnancies (OR:1.20, 95%CI:1.01–1.43, p < 0.04 ), and working in the healthcare sector (OR:8.68, 95%CI:1.72–43.62, p < 0.01 ), remained significantly associated with chronic HCV infection. Conclusions Universal antenatal HCV screening was widely accepted (100%) and traditional risk-based screening alone would have missed 3 (10%) chronically infected women, thereby supporting universal screening of pregnant women whenever possible. Otherwise, risk-based screening should be modified to include history of prior pregnancy and healthcare employment.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Cross-Sectional Studies</subject><subject>Egypt</subject><subject>Egypt - epidemiology</subject><subject>Female</subject><subject>Hepacivirus - genetics</subject><subject>Hepacivirus - isolation & purification</subject><subject>Hepatitis C</subject><subject>Hepatitis C - diagnosis</subject><subject>Hepatitis C - epidemiology</subject><subject>Hepatitis C Antibodies - blood</subject><subject>Hepatitis C, Chronic - diagnosis</subject><subject>Hepatitis C, Chronic - epidemiology</subject><subject>Humans</subject><subject>Infectious Disease</subject><subject>Mass Screening</subject><subject>Middle Aged</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - diagnosis</subject><subject>Pregnancy Complications, Infectious - epidemiology</subject><subject>Prevalence</subject><subject>Reproducibility of Results</subject><subject>Risk Factors</subject><subject>Young Adult</subject><issn>0163-4453</issn><issn>1532-2742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1DAURi0EosPAH2CBvGST4GceEkJCo_KQKiG1sLYc53pwmtjBTlrNv8fRFBZddHUX99zP8vkQektJSQmtPgzl4LwtGaGyJLQkpH2GdlRyVrBasOdolyFeCCH5BXqV0kAywdvqJbpgsmKc1tUO6WsYne7c6JYTDhZHl26LTifocTIRwDt_xDZE_BtmvbjFJXzAdy6uCee3wSwueKynkKk5wtFrv-D7MIHPa3x5PM3La_TC6jHBm4e5R7--XP48fCuufnz9fvh8VRjR0KXQsmO8owQ42AbazvRNU5G60Vpa0bAW6lqKVgIzLQheGyuZ6ImlHHhPRAd8j96fc-cY_qyQFjW5ZGActYewJkWrmpOa8zz2iJ1RE0NKEayao5t0PClK1KZWDWpTqza1ilC1idujdw_5azdB___kn8sMfDwDkH955yCqZBx4A72LWZTqg3s6_9OjczM674web-EEaQhr9NmfoioxRdTNVu7WLZW5V04E_wuMLp_i</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>El-Kamary, Samer S</creator><creator>Hashem, Mohamed</creator><creator>Saleh, Doa'a A</creator><creator>Ehab, Mohamed</creator><creator>Sharaf, Sahar A</creator><creator>El-Mougy, Fatma</creator><creator>Abdelsalam, Lobna</creator><creator>Jhaveri, Ravi</creator><creator>Aboulnasr, Ahmed</creator><creator>El-Ghazaly, Hesham</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1137-7079</orcidid><orcidid>https://orcid.org/0000-0001-9921-0419</orcidid></search><sort><creationdate>20150501</creationdate><title>Reliability of risk-based screening for hepatitis C virus infection among pregnant women in Egypt</title><author>El-Kamary, Samer S ; Hashem, Mohamed ; Saleh, Doa'a A ; Ehab, Mohamed ; Sharaf, Sahar A ; El-Mougy, Fatma ; Abdelsalam, Lobna ; Jhaveri, Ravi ; Aboulnasr, Ahmed ; El-Ghazaly, Hesham</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-a5b23b10e3ef8e9bcd886078aa5f4829e775495e2c9e437cf524d0f13e3d04be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Cross-Sectional Studies</topic><topic>Egypt</topic><topic>Egypt - epidemiology</topic><topic>Female</topic><topic>Hepacivirus - genetics</topic><topic>Hepacivirus - isolation & purification</topic><topic>Hepatitis C</topic><topic>Hepatitis C - diagnosis</topic><topic>Hepatitis C - epidemiology</topic><topic>Hepatitis C Antibodies - blood</topic><topic>Hepatitis C, Chronic - diagnosis</topic><topic>Hepatitis C, Chronic - epidemiology</topic><topic>Humans</topic><topic>Infectious Disease</topic><topic>Mass Screening</topic><topic>Middle Aged</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - diagnosis</topic><topic>Pregnancy Complications, Infectious - epidemiology</topic><topic>Prevalence</topic><topic>Reproducibility of Results</topic><topic>Risk Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Kamary, Samer S</creatorcontrib><creatorcontrib>Hashem, Mohamed</creatorcontrib><creatorcontrib>Saleh, Doa'a A</creatorcontrib><creatorcontrib>Ehab, Mohamed</creatorcontrib><creatorcontrib>Sharaf, Sahar A</creatorcontrib><creatorcontrib>El-Mougy, Fatma</creatorcontrib><creatorcontrib>Abdelsalam, Lobna</creatorcontrib><creatorcontrib>Jhaveri, Ravi</creatorcontrib><creatorcontrib>Aboulnasr, Ahmed</creatorcontrib><creatorcontrib>El-Ghazaly, Hesham</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Kamary, Samer S</au><au>Hashem, Mohamed</au><au>Saleh, Doa'a A</au><au>Ehab, Mohamed</au><au>Sharaf, Sahar A</au><au>El-Mougy, Fatma</au><au>Abdelsalam, Lobna</au><au>Jhaveri, Ravi</au><au>Aboulnasr, Ahmed</au><au>El-Ghazaly, Hesham</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reliability of risk-based screening for hepatitis C virus infection among pregnant women in Egypt</atitle><jtitle>The Journal of infection</jtitle><addtitle>J Infect</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>70</volume><issue>5</issue><spage>512</spage><epage>519</epage><pages>512-519</pages><issn>0163-4453</issn><eissn>1532-2742</eissn><abstract>Summary Objectives The Centers for Disease Control and Prevention (CDC) only recommends risk-based HCV screening for pregnant women in the United States. This study sought to determine the reliability of risk-based versus universal HCV screening for pregnant women in Egypt, a country with the world's highest HCV prevalence that also relies on risk-based screening, and to identify additional characteristics that could increase the reliability of risk-based screening. Methods Pregnant women attending the Cairo University antenatal clinic were tested for anti-HCV antibodies and RNA, and demographic characteristics and risk factors for infection were assessed. Results All 1250 pregnant women approached agreed to participate (100%) with a mean age of 27.4 ± 5.5 years (range:16–45). HCV antibodies and RNA were positive in 52 (4.2%) and 30 (2.4%) women respectively. After adjustment, only age (OR:1.08, 95%CI:1.002–1.16, p < 0.01 ), history of prior pregnancies (OR:1.20, 95%CI:1.01–1.43, p < 0.04 ), and working in the healthcare sector (OR:8.68, 95%CI:1.72–43.62, p < 0.01 ), remained significantly associated with chronic HCV infection. Conclusions Universal antenatal HCV screening was widely accepted (100%) and traditional risk-based screening alone would have missed 3 (10%) chronically infected women, thereby supporting universal screening of pregnant women whenever possible. Otherwise, risk-based screening should be modified to include history of prior pregnancy and healthcare employment.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>25623176</pmid><doi>10.1016/j.jinf.2015.01.009</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1137-7079</orcidid><orcidid>https://orcid.org/0000-0001-9921-0419</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-4453 |
| ispartof | The Journal of infection, 2015-05, Vol.70 (5), p.512-519 |
| issn | 0163-4453 1532-2742 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1673073367 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Cross-Sectional Studies Egypt Egypt - epidemiology Female Hepacivirus - genetics Hepacivirus - isolation & purification Hepatitis C Hepatitis C - diagnosis Hepatitis C - epidemiology Hepatitis C Antibodies - blood Hepatitis C, Chronic - diagnosis Hepatitis C, Chronic - epidemiology Humans Infectious Disease Mass Screening Middle Aged Pregnancy Pregnancy Complications, Infectious - diagnosis Pregnancy Complications, Infectious - epidemiology Prevalence Reproducibility of Results Risk Factors Young Adult |
| title | Reliability of risk-based screening for hepatitis C virus infection among pregnant women in Egypt |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T00%3A09%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Reliability%20of%20risk-based%20screening%20for%20hepatitis%20C%20virus%20infection%20among%20pregnant%20women%20in%20Egypt&rft.jtitle=The%20Journal%20of%20infection&rft.au=El-Kamary,%20Samer%20S&rft.date=2015-05-01&rft.volume=70&rft.issue=5&rft.spage=512&rft.epage=519&rft.pages=512-519&rft.issn=0163-4453&rft.eissn=1532-2742&rft_id=info:doi/10.1016/j.jinf.2015.01.009&rft_dat=%3Cproquest_cross%3E1673073367%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1673073367&rft_id=info:pmid/25623176&rft_els_id=S0163445315000304&rfr_iscdi=true |