Inhibition of histone deacetylases enhances the function of serotoninergic neurons in organotypic raphe slice cultures

•We examined the effects of HDAC inhibitors on 5-HT neurons in raphe slice cultures.•Sustained treatment with trichostatin A (TSA) increased 5-HT synthesis and release.•TSA enhanced AMPAR-mediated 5-HT release with increased GluA2 gene expression.•CaMKII inhibitors blocked TSA-induced increase in 5-...

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Veröffentlicht in:	Neuroscience letters 2015-04, Vol.593, p.72-77
Hauptverfasser:	Asaoka, Nozomi, Nagayasu, Kazuki, Nishitani, Naoya, Yamashiro, Mayumi, Shirakawa, Hisashi, Nakagawa, Takayuki, Kaneko, Shuji
Format:	Artikel
Sprache:	eng
Schlagworte:	AMPA receptor Animals Ca2+/calmodulin-dependent kinase II Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Hydroxamic Acids - pharmacology Raphe Nuclei - drug effects Raphe Nuclei - physiology Raphe slice cultures Rats, Wistar Receptors, Glutamate - metabolism Serotonergic Neurons - drug effects Serotonergic Neurons - physiology Serotonin Serotonin - metabolism Tissue Culture Techniques Transcription, Genetic Trichostatin A Tryptophan Hydroxylase - genetics Tryptophan Hydroxylase - metabolism
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