Thromboxane prostanoid receptors enhance contractions, endothelin-1, and oxidative stress in microvessels from mice with chronic kidney disease

Cardiovascular disease is frequent in chronic kidney disease and has been related to angiotensin II, endothelin-1 (ET-1), thromboxane A2, and reactive oxygen species (ROS). Because activation of thromboxane prostanoid receptors (TP-Rs) can generate ROS, which can generate ET-1, we tested the hypothe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2015-05, Vol.65 (5), p.1055-1063
Hauptverfasser:	Wang, Cheng, Luo, Zaiming, Kohan, Donald, Wellstein, Anton, Jose, Pedro A, Welch, William J, Wilcox, Christopher S, Wang, Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arterioles - metabolism Arterioles - physiopathology Disease Models, Animal Endothelin-1 - biosynthesis Endothelin-1 - genetics Gene Expression Regulation Kidney - blood supply Male Mice Mice, Inbred C57BL Oxidative Stress Reactive Oxygen Species - metabolism Real-Time Polymerase Chain Reaction Receptors, Thromboxane - biosynthesis Receptors, Thromboxane - genetics Renal Circulation Renal Insufficiency, Chronic - genetics Renal Insufficiency, Chronic - metabolism Renal Insufficiency, Chronic - physiopathology RNA - genetics Vascular Remodeling Vasoconstriction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!