Effect of rectal enema on intrafraction prostate movement during image-guided radiotherapy
Introduction Rectal volume and movement are major factors that influence prostate location. The aim of this study was to assess the effect of a rectal enema on intrafraction prostate motion. Methods The data from 12 patients with localised prostate cancer were analysed. Each patient underwent image‐...
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| Veröffentlicht in: | Journal of medical imaging and radiation oncology 2015-04, Vol.59 (2), p.236-242 |
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| creator | Choi, Youngmin Kwak, Dong-Won Lee, Hyung-Sik Hur, Won-Joo Cho, Won-Yeol Sung, Gyung Tak Kim, Tae-Hyo Kim, Soo-Dong Yun, Seong-Guk |
| description | Introduction
Rectal volume and movement are major factors that influence prostate location. The aim of this study was to assess the effect of a rectal enema on intrafraction prostate motion.
Methods
The data from 12 patients with localised prostate cancer were analysed. Each patient underwent image‐guided radiotherapy (RT), receiving a total dose of 70 Gy in 28 fractions. Rectal enemas were administered to all of the patients before each RT fraction. The location of the prostate was determined by implanting three fiducial markers under the guidance of transrectal ultrasound. Each patient underwent preparation for IGRT twice before an RT fraction and in the middle of the fraction. The intrafraction displacement of the prostate was calculated by comparing fiducial marker locations before and in the middle of an RT fraction.
Results
The rectal enemas were well tolerated by patients. The mean intrafraction prostate movement in 336 RT fractions was 1.11 ± 0.77 mm (range 0.08–7.20 mm). Intrafraction motions of 1, 2 and 3 mm were observed in 56.0%, 89.0% and 97.6% of all RT fractions, respectively. The intrafraction movements on supero‐inferior and anteroposterior axes were larger than on the right‐to‐left axes (P |
| doi_str_mv | 10.1111/1754-9485.12239 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1672610127</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3647504221</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4119-88514f18c2702d7d5fced2cc04b24a3f5afeea57d0efb83b16ee9041d209a5c83</originalsourceid><addsrcrecordid>eNqFkL1vFDEQxS1EREKgpkOWaNJs4vGu1-sSTiHkG6IgJBrLZ4-PDftx2F7g_nt8ueQKmkwzY-v3nmYeIW-AHUKuI5CiKlTViEPgvFTPyN725_l2lnKXvIzxjrEaoFIvyC4XnCvJyz3y_dh7tImOnobcTUdxwN7QcaDtkILxwdjU5tcyjDGZhLQff2OPQ6JuCu2woG1vFlgsptaho8G4dkw_MJjl6hXZ8aaL-Pqh75OvH49vZ5-Ki-uT09n7i8JWAKpoGgGVh8ZyybiTTniLjlvLqjmvTOmF8YhGSMfQz5tyDjWiYhU4zpQRtin3ycHGN6_4a8KYdN9Gi11nBhynqKGWvAYGXGb03X_o3TiFIW-3ppgCwaTK1NGGsvnmGNDrZchXhpUGptex63Wweh2yvo89K94--E7zHt2Wf8w5A3ID_Gk7XD3lp88uT2-uH62LjbKNCf9ulSb81LUspdDfrk40XH75MDu_vdGfy3_HLZzB</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1670915079</pqid></control><display><type>article</type><title>Effect of rectal enema on intrafraction prostate movement during image-guided radiotherapy</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Choi, Youngmin ; Kwak, Dong-Won ; Lee, Hyung-Sik ; Hur, Won-Joo ; Cho, Won-Yeol ; Sung, Gyung Tak ; Kim, Tae-Hyo ; Kim, Soo-Dong ; Yun, Seong-Guk</creator><creatorcontrib>Choi, Youngmin ; Kwak, Dong-Won ; Lee, Hyung-Sik ; Hur, Won-Joo ; Cho, Won-Yeol ; Sung, Gyung Tak ; Kim, Tae-Hyo ; Kim, Soo-Dong ; Yun, Seong-Guk</creatorcontrib><description>Introduction
Rectal volume and movement are major factors that influence prostate location. The aim of this study was to assess the effect of a rectal enema on intrafraction prostate motion.
Methods
The data from 12 patients with localised prostate cancer were analysed. Each patient underwent image‐guided radiotherapy (RT), receiving a total dose of 70 Gy in 28 fractions. Rectal enemas were administered to all of the patients before each RT fraction. The location of the prostate was determined by implanting three fiducial markers under the guidance of transrectal ultrasound. Each patient underwent preparation for IGRT twice before an RT fraction and in the middle of the fraction. The intrafraction displacement of the prostate was calculated by comparing fiducial marker locations before and in the middle of an RT fraction.
Results
The rectal enemas were well tolerated by patients. The mean intrafraction prostate movement in 336 RT fractions was 1.11 ± 0.77 mm (range 0.08–7.20 mm). Intrafraction motions of 1, 2 and 3 mm were observed in 56.0%, 89.0% and 97.6% of all RT fractions, respectively. The intrafraction movements on supero‐inferior and anteroposterior axes were larger than on the right‐to‐left axes (P < 0.05). The CTV‐to‐PTV margin necessary to allow for movement, calculated using the van Herk formula (2.5Σ + 0.7σ), was 1.50 mm.
Conclusions
A daily rectal enema before each RT fraction was tolerable and yielded little intrafraction prostate displacement. We think the use of rectal enemas is a feasible method to reduce prostate movement during RT.</description><identifier>ISSN: 1754-9477</identifier><identifier>EISSN: 1754-9485</identifier><identifier>DOI: 10.1111/1754-9485.12239</identifier><identifier>PMID: 25229723</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Aged ; Dose Hypofractionation ; enema ; Enema - methods ; Humans ; image-guided radiotherapy ; Male ; Movement ; Patients ; prostate neoplasm ; Prostatic Neoplasms - diagnostic imaging ; Prostatic Neoplasms - radiotherapy ; Radiation therapy ; Radiography ; Radiotherapy, Image-Guided - methods ; Reproducibility of Results ; Retrospective Studies ; Sensitivity and Specificity</subject><ispartof>Journal of medical imaging and radiation oncology, 2015-04, Vol.59 (2), p.236-242</ispartof><rights>2014 The Royal Australian and New Zealand College of Radiologists</rights><rights>2014 The Royal Australian and New Zealand College of Radiologists.</rights><rights>Copyright © 2015 Royal Australian and New Zealand College of Radiologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4119-88514f18c2702d7d5fced2cc04b24a3f5afeea57d0efb83b16ee9041d209a5c83</citedby><cites>FETCH-LOGICAL-c4119-88514f18c2702d7d5fced2cc04b24a3f5afeea57d0efb83b16ee9041d209a5c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1754-9485.12239$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1754-9485.12239$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25229723$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Youngmin</creatorcontrib><creatorcontrib>Kwak, Dong-Won</creatorcontrib><creatorcontrib>Lee, Hyung-Sik</creatorcontrib><creatorcontrib>Hur, Won-Joo</creatorcontrib><creatorcontrib>Cho, Won-Yeol</creatorcontrib><creatorcontrib>Sung, Gyung Tak</creatorcontrib><creatorcontrib>Kim, Tae-Hyo</creatorcontrib><creatorcontrib>Kim, Soo-Dong</creatorcontrib><creatorcontrib>Yun, Seong-Guk</creatorcontrib><title>Effect of rectal enema on intrafraction prostate movement during image-guided radiotherapy</title><title>Journal of medical imaging and radiation oncology</title><addtitle>Journal of Medical Imaging and Radiation Oncology</addtitle><description>Introduction
Rectal volume and movement are major factors that influence prostate location. The aim of this study was to assess the effect of a rectal enema on intrafraction prostate motion.
Methods
The data from 12 patients with localised prostate cancer were analysed. Each patient underwent image‐guided radiotherapy (RT), receiving a total dose of 70 Gy in 28 fractions. Rectal enemas were administered to all of the patients before each RT fraction. The location of the prostate was determined by implanting three fiducial markers under the guidance of transrectal ultrasound. Each patient underwent preparation for IGRT twice before an RT fraction and in the middle of the fraction. The intrafraction displacement of the prostate was calculated by comparing fiducial marker locations before and in the middle of an RT fraction.
Results
The rectal enemas were well tolerated by patients. The mean intrafraction prostate movement in 336 RT fractions was 1.11 ± 0.77 mm (range 0.08–7.20 mm). Intrafraction motions of 1, 2 and 3 mm were observed in 56.0%, 89.0% and 97.6% of all RT fractions, respectively. The intrafraction movements on supero‐inferior and anteroposterior axes were larger than on the right‐to‐left axes (P < 0.05). The CTV‐to‐PTV margin necessary to allow for movement, calculated using the van Herk formula (2.5Σ + 0.7σ), was 1.50 mm.
Conclusions
A daily rectal enema before each RT fraction was tolerable and yielded little intrafraction prostate displacement. We think the use of rectal enemas is a feasible method to reduce prostate movement during RT.</description><subject>Aged</subject><subject>Dose Hypofractionation</subject><subject>enema</subject><subject>Enema - methods</subject><subject>Humans</subject><subject>image-guided radiotherapy</subject><subject>Male</subject><subject>Movement</subject><subject>Patients</subject><subject>prostate neoplasm</subject><subject>Prostatic Neoplasms - diagnostic imaging</subject><subject>Prostatic Neoplasms - radiotherapy</subject><subject>Radiation therapy</subject><subject>Radiography</subject><subject>Radiotherapy, Image-Guided - methods</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><issn>1754-9477</issn><issn>1754-9485</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1vFDEQxS1EREKgpkOWaNJs4vGu1-sSTiHkG6IgJBrLZ4-PDftx2F7g_nt8ueQKmkwzY-v3nmYeIW-AHUKuI5CiKlTViEPgvFTPyN725_l2lnKXvIzxjrEaoFIvyC4XnCvJyz3y_dh7tImOnobcTUdxwN7QcaDtkILxwdjU5tcyjDGZhLQff2OPQ6JuCu2woG1vFlgsptaho8G4dkw_MJjl6hXZ8aaL-Pqh75OvH49vZ5-Ki-uT09n7i8JWAKpoGgGVh8ZyybiTTniLjlvLqjmvTOmF8YhGSMfQz5tyDjWiYhU4zpQRtin3ycHGN6_4a8KYdN9Gi11nBhynqKGWvAYGXGb03X_o3TiFIW-3ppgCwaTK1NGGsvnmGNDrZchXhpUGptex63Wweh2yvo89K94--E7zHt2Wf8w5A3ID_Gk7XD3lp88uT2-uH62LjbKNCf9ulSb81LUspdDfrk40XH75MDu_vdGfy3_HLZzB</recordid><startdate>201504</startdate><enddate>201504</enddate><creator>Choi, Youngmin</creator><creator>Kwak, Dong-Won</creator><creator>Lee, Hyung-Sik</creator><creator>Hur, Won-Joo</creator><creator>Cho, Won-Yeol</creator><creator>Sung, Gyung Tak</creator><creator>Kim, Tae-Hyo</creator><creator>Kim, Soo-Dong</creator><creator>Yun, Seong-Guk</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201504</creationdate><title>Effect of rectal enema on intrafraction prostate movement during image-guided radiotherapy</title><author>Choi, Youngmin ; Kwak, Dong-Won ; Lee, Hyung-Sik ; Hur, Won-Joo ; Cho, Won-Yeol ; Sung, Gyung Tak ; Kim, Tae-Hyo ; Kim, Soo-Dong ; Yun, Seong-Guk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4119-88514f18c2702d7d5fced2cc04b24a3f5afeea57d0efb83b16ee9041d209a5c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Dose Hypofractionation</topic><topic>enema</topic><topic>Enema - methods</topic><topic>Humans</topic><topic>image-guided radiotherapy</topic><topic>Male</topic><topic>Movement</topic><topic>Patients</topic><topic>prostate neoplasm</topic><topic>Prostatic Neoplasms - diagnostic imaging</topic><topic>Prostatic Neoplasms - radiotherapy</topic><topic>Radiation therapy</topic><topic>Radiography</topic><topic>Radiotherapy, Image-Guided - methods</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Youngmin</creatorcontrib><creatorcontrib>Kwak, Dong-Won</creatorcontrib><creatorcontrib>Lee, Hyung-Sik</creatorcontrib><creatorcontrib>Hur, Won-Joo</creatorcontrib><creatorcontrib>Cho, Won-Yeol</creatorcontrib><creatorcontrib>Sung, Gyung Tak</creatorcontrib><creatorcontrib>Kim, Tae-Hyo</creatorcontrib><creatorcontrib>Kim, Soo-Dong</creatorcontrib><creatorcontrib>Yun, Seong-Guk</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical imaging and radiation oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Youngmin</au><au>Kwak, Dong-Won</au><au>Lee, Hyung-Sik</au><au>Hur, Won-Joo</au><au>Cho, Won-Yeol</au><au>Sung, Gyung Tak</au><au>Kim, Tae-Hyo</au><au>Kim, Soo-Dong</au><au>Yun, Seong-Guk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of rectal enema on intrafraction prostate movement during image-guided radiotherapy</atitle><jtitle>Journal of medical imaging and radiation oncology</jtitle><addtitle>Journal of Medical Imaging and Radiation Oncology</addtitle><date>2015-04</date><risdate>2015</risdate><volume>59</volume><issue>2</issue><spage>236</spage><epage>242</epage><pages>236-242</pages><issn>1754-9477</issn><eissn>1754-9485</eissn><abstract>Introduction
Rectal volume and movement are major factors that influence prostate location. The aim of this study was to assess the effect of a rectal enema on intrafraction prostate motion.
Methods
The data from 12 patients with localised prostate cancer were analysed. Each patient underwent image‐guided radiotherapy (RT), receiving a total dose of 70 Gy in 28 fractions. Rectal enemas were administered to all of the patients before each RT fraction. The location of the prostate was determined by implanting three fiducial markers under the guidance of transrectal ultrasound. Each patient underwent preparation for IGRT twice before an RT fraction and in the middle of the fraction. The intrafraction displacement of the prostate was calculated by comparing fiducial marker locations before and in the middle of an RT fraction.
Results
The rectal enemas were well tolerated by patients. The mean intrafraction prostate movement in 336 RT fractions was 1.11 ± 0.77 mm (range 0.08–7.20 mm). Intrafraction motions of 1, 2 and 3 mm were observed in 56.0%, 89.0% and 97.6% of all RT fractions, respectively. The intrafraction movements on supero‐inferior and anteroposterior axes were larger than on the right‐to‐left axes (P < 0.05). The CTV‐to‐PTV margin necessary to allow for movement, calculated using the van Herk formula (2.5Σ + 0.7σ), was 1.50 mm.
Conclusions
A daily rectal enema before each RT fraction was tolerable and yielded little intrafraction prostate displacement. We think the use of rectal enemas is a feasible method to reduce prostate movement during RT.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>25229723</pmid><doi>10.1111/1754-9485.12239</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Dose Hypofractionation enema Enema - methods Humans image-guided radiotherapy Male Movement Patients prostate neoplasm Prostatic Neoplasms - diagnostic imaging Prostatic Neoplasms - radiotherapy Radiation therapy Radiography Radiotherapy, Image-Guided - methods Reproducibility of Results Retrospective Studies Sensitivity and Specificity |
| title | Effect of rectal enema on intrafraction prostate movement during image-guided radiotherapy |
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