Chemical libraries dedicated to protein-protein interactions

The identification of complete networks of protein-protein interactions (PPI) within a cell has contributed to major breakthroughs in understanding biological pathways, host-pathogen interactions and cancer development. As a consequence, PPI have emerged as a new class of promising therapeutic targe...

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Veröffentlicht in:M.S. Médecine sciences 2015-03, Vol.31 (3), p.312-319
Hauptverfasser: Sperandio, Olivier, Villoutreix, Bruno O, Morelli, Xavier, Roche, Philippe
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container_title M.S. Médecine sciences
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creator Sperandio, Olivier
Villoutreix, Bruno O
Morelli, Xavier
Roche, Philippe
description The identification of complete networks of protein-protein interactions (PPI) within a cell has contributed to major breakthroughs in understanding biological pathways, host-pathogen interactions and cancer development. As a consequence, PPI have emerged as a new class of promising therapeutic targets. However, they are still considered as a challenging class of targets for drug discovery programs. Recent successes have allowed the characterization of structural and physicochemical properties of protein-protein interfaces leading to a better understanding of how they can be disrupted with small molecule compounds. In addition, characterization of the profiles of PPI inhibitors has allowed the development of PPI-focused libraries. In this review, we present the current efforts at developing chemical libraries dedicated to these innovative targets.
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source MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
subjects Animals
Commerce
Drug Discovery - economics
Drug Discovery - methods
Humans
Protein Binding
Protein Interaction Mapping - methods
Signal Transduction
Small Molecule Libraries - economics
Small Molecule Libraries - metabolism
title Chemical libraries dedicated to protein-protein interactions
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