Chemical libraries dedicated to protein-protein interactions
The identification of complete networks of protein-protein interactions (PPI) within a cell has contributed to major breakthroughs in understanding biological pathways, host-pathogen interactions and cancer development. As a consequence, PPI have emerged as a new class of promising therapeutic targe...
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Veröffentlicht in: | M.S. Médecine sciences 2015-03, Vol.31 (3), p.312-319 |
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creator | Sperandio, Olivier Villoutreix, Bruno O Morelli, Xavier Roche, Philippe |
description | The identification of complete networks of protein-protein interactions (PPI) within a cell has contributed to major breakthroughs in understanding biological pathways, host-pathogen interactions and cancer development. As a consequence, PPI have emerged as a new class of promising therapeutic targets. However, they are still considered as a challenging class of targets for drug discovery programs. Recent successes have allowed the characterization of structural and physicochemical properties of protein-protein interfaces leading to a better understanding of how they can be disrupted with small molecule compounds. In addition, characterization of the profiles of PPI inhibitors has allowed the development of PPI-focused libraries. In this review, we present the current efforts at developing chemical libraries dedicated to these innovative targets. |
doi_str_mv | 10.1051/medsci/20153103017 |
format | Article |
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subjects | Animals Commerce Drug Discovery - economics Drug Discovery - methods Humans Protein Binding Protein Interaction Mapping - methods Signal Transduction Small Molecule Libraries - economics Small Molecule Libraries - metabolism |
title | Chemical libraries dedicated to protein-protein interactions |
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