Administration of Interleukin-2 (IL-2) Results in Increased Plasma Concentrations of IL-5 and Eosinophilia in Patients With Cancer

Peripheral eosinophilia is almost invariably observed during the course of interleukin-2 (IL-2) therapy and is frequently accompanied by the development of a capillary leak syndrome characterized by edema, weight gain, and oliguria. We studied five patients with advanced malignancy treated with IL-2...

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Veröffentlicht in:	Blood 1991-09, Vol.78 (6), p.1538-1544
Hauptverfasser:	Pisani, Carol van Haelst, Kovach, John S., Kita, Hirohito, Leiferman, Kristin M., Gleich, Gerald J., Silver, Jon E., Dennin, Robert, Abrams, John S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Blood Proteins - analysis Carcinoma, Renal Cell - blood Carcinoma, Renal Cell - therapy Eosinophil Granule Proteins Eosinophilia - etiology Female Humans Interleukin-2 - administration & dosage Interleukin-2 - adverse effects Interleukin-4 - blood Interleukin-5 - blood Kidney Neoplasms - blood Kidney Neoplasms - therapy Male Medical sciences Melanoma - blood Melanoma - therapy Middle Aged Recombinant Proteins - administration & dosage Recombinant Proteins - adverse effects Ribonucleases Tumors
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