Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3'-kinase, and protein kinase C

The receptor tyrosine kinase Kit and Kit ligand (KL), encoded at the murine white spotting (W) and steel (Sl) loci, respectively, function in hematopoiesis, melanogenesis, and gametogenesis. To understand the mechanism of turnover of Kit in mast cells, mutant receptors generated in vitro were hetero...

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Veröffentlicht in:	The Journal of biological chemistry 1994-12, Vol.269 (50), p.31991-31998
Hauptverfasser:	Yee, N.S., Hsiau, C.W., Serve, H, Vosseller, K, Besmer, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA Mutational Analysis Down-Regulation Endopeptidases - metabolism Hematopoietic Cell Growth Factors - metabolism Mast Cells - metabolism Mice Mice, Inbred C57BL Mice, Mutant Strains Molecular Weight Peptide Fragments - chemistry Peptide Fragments - metabolism Phosphatidylinositol 3-Kinases Phosphorylation Phosphotransferases (Alcohol Group Acceptor) - metabolism Phosphotyrosine Protein Kinase C - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-kit Receptor Protein-Tyrosine Kinases - metabolism Receptors, Colony-Stimulating Factor - metabolism Stem Cell Factor Structure-Activity Relationship Tetradecanoylphorbol Acetate - pharmacology Time Factors Tyrosine - analogs & derivatives Tyrosine - metabolism Ubiquitins - metabolism
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