Endocrinopathies, metabolic disorders, and iron overload in major and intermedia thalassemia: serum ferritin as diagnostic and predictive marker associated with liver and cardiac T2 MRI assessment

Introduction Endocrinopathies and metabolic disorders‐characterized β thalassemic (βT) patients and the prevention and treatment of these comorbidities are important targets to be achieved. The aim of the study was to analyze the diagnostic and prognostic role of ferritin for endocrinopathies and me...

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Veröffentlicht in:	European journal of haematology 2015-05, Vol.94 (5), p.404-412
Hauptverfasser:	Chirico, Valeria, Rigoli, Luciana, Lacquaniti, Antonio, Salpietro, Vincenzo, Piraino, Basilia, Amorini, Maria, Salpietro, Carmelo, Arrigo, Teresa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult beta-Thalassemia - diagnosis beta-Thalassemia - epidemiology beta-Thalassemia - pathology beta-Thalassemia - therapy Biomarkers - blood Chelation Therapy Comorbidity endocrinopathies Female ferritin Ferritins - blood Humans Hypogonadism - diagnosis Hypogonadism - epidemiology Hypogonadism - pathology Hypogonadism - therapy hypothyroidism Hypothyroidism - diagnosis Hypothyroidism - epidemiology Hypothyroidism - pathology Hypothyroidism - therapy Iron - blood Iron Chelating Agents - therapeutic use iron chelation therapy Iron Overload - diagnosis Iron Overload - epidemiology Iron Overload - etiology Iron Overload - therapy Italy - epidemiology Liver - metabolism Liver - pathology Magnetic Resonance Imaging Male Middle Aged Myocardium - metabolism Myocardium - pathology Osteoporosis - diagnosis Osteoporosis - epidemiology Osteoporosis - pathology Osteoporosis - therapy Predictive Value of Tests Proportional Hazards Models ROC Curve thalassemia Transfusion Reaction
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