Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an endogenous secreted peptide and, in preclinical studies, preferentially induces apoptosis in tumor cells rather than in normal cells. The acquisition of resistance in cells exposed to TRAIL or its mimics limits their clinical effi...

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Veröffentlicht in:	Science signaling 2015-04, Vol.8 (371), p.rs3-rs3
Hauptverfasser:	So, Jonathan, Pasculescu, Adrian, Dai, Anna Y, Williton, Kelly, James, Andrew, Nguyen, Vivian, Creixell, Pau, Schoof, Erwin M, Sinclair, John, Barrios-Rodiles, Miriam, Gu, Jun, Krizus, Aldis, Williams, Ryan, Olhovsky, Marina, Dennis, James W, Wrana, Jeffrey L, Linding, Rune, Jorgensen, Claus, Pawson, Tony, Colwill, Karen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma - therapy Apoptosis Cell Line, Tumor Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colonic Neoplasms - therapy HEK293 Cells Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Signal Transduction TNF-Related Apoptosis-Inducing Ligand - genetics TNF-Related Apoptosis-Inducing Ligand - metabolism
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