Copper-catalyzed aerobic cascade cycloamination and acyloxylation: a direct approach to 4-acyloxy-1H-pyrazoles
A novel direct transformation of hydrazones to acyloxylated pyrazoles by copper-catalyzed regioselective olefinic C(sp(2))-H bond cycloamination and acyloxylation was performed under mild conditions, which combines the formation of the pyrazole skeleton and installation of an acyloxyl group in a sin...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2015-04, Vol.13 (16), p.4642-4646 |
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| container_issue | 16 |
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| container_title | Organic & biomolecular chemistry |
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| creator | Ding, Zhengwei Tan, Qitao Gao, Mingchun Xu, Bin |
| description | A novel direct transformation of hydrazones to acyloxylated pyrazoles by copper-catalyzed regioselective olefinic C(sp(2))-H bond cycloamination and acyloxylation was performed under mild conditions, which combines the formation of the pyrazole skeleton and installation of an acyloxyl group in a single step, using facile carboxylic acids as the acyloxylation reagents. |
| doi_str_mv | 10.1039/c5ob00409h |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Organic & biomolecular chemistry, 2015-04, Vol.13 (16), p.4642-4646 |
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| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Carboxylic Acids - chemistry Catalysis Copper - chemistry Cyclization Drug Design Hydrazines - chemistry Hydrazones - chemistry Hydrogen Bonding Ligands Metals - chemistry Models, Chemical Molecular Structure Organic Chemicals - chemistry Pyrazoles - chemistry |
| title | Copper-catalyzed aerobic cascade cycloamination and acyloxylation: a direct approach to 4-acyloxy-1H-pyrazoles |
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