Copper-catalyzed aerobic cascade cycloamination and acyloxylation: a direct approach to 4-acyloxy-1H-pyrazoles

Copper-catalyzed aerobic cascade cycloamination and acyloxylation: a direct approach to 4-acyloxy-1H-pyrazoles

A novel direct transformation of hydrazones to acyloxylated pyrazoles by copper-catalyzed regioselective olefinic C(sp(2))-H bond cycloamination and acyloxylation was performed under mild conditions, which combines the formation of the pyrazole skeleton and installation of an acyloxyl group in a sin...

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Veröffentlicht in:Organic & biomolecular chemistry 2015-04, Vol.13 (16), p.4642-4646
Hauptverfasser: Ding, Zhengwei, Tan, Qitao, Gao, Mingchun, Xu, Bin
Format: Artikel
Sprache:eng
Schlagworte:
Carboxylic Acids - chemistry
Catalysis
Copper - chemistry
Cyclization
Drug Design
Hydrazines - chemistry
Hydrazones - chemistry
Hydrogen Bonding
Ligands
Metals - chemistry
Models, Chemical
Molecular Structure
Organic Chemicals - chemistry
Pyrazoles - chemistry
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Zusammenfassung:A novel direct transformation of hydrazones to acyloxylated pyrazoles by copper-catalyzed regioselective olefinic C(sp(2))-H bond cycloamination and acyloxylation was performed under mild conditions, which combines the formation of the pyrazole skeleton and installation of an acyloxyl group in a single step, using facile carboxylic acids as the acyloxylation reagents.
ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob00409h