A copper-catalyzed one-pot, three-component tandem conjugative alkynylation/6-endo cyclization sequence: access to pyrano[2,3-d]-pyrimidines

A copper-catalyzed one-pot, three-component tandem conjugative alkynylation/6-endo cyclization sequence: access to pyrano[2,3-d]-pyrimidines

A copper catalyzed one-pot, three component reaction between barbituric acid, aldehydes and terminal alkynes has been developed for the construction of pyrano[2,3-d]pyrimidines via a tandem conjugative alkynylation/6-endo cyclization pattern. Screening of barbituric acid derived organic acceptors in...

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Veröffentlicht in:Organic & biomolecular chemistry 2015-04, Vol.13 (16), p.4668-4672
Hauptverfasser: Rajesh, Nimmakuri, Prajapati, Dipak
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creator Rajesh, Nimmakuri
Prajapati, Dipak
description A copper catalyzed one-pot, three component reaction between barbituric acid, aldehydes and terminal alkynes has been developed for the construction of pyrano[2,3-d]pyrimidines via a tandem conjugative alkynylation/6-endo cyclization pattern. Screening of barbituric acid derived organic acceptors in conjugative alkynylation reaction and the synthetic applicability of conjugative addition products under one-pot conditions were documented for the first time.
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title A copper-catalyzed one-pot, three-component tandem conjugative alkynylation/6-endo cyclization sequence: access to pyrano[2,3-d]-pyrimidines
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