Histidine-419 plays a role in energy coupling in the vesicular monoamine transporter from rat

Vesicular monoamine transporters (VMAT) catalyze transport of serotonin, dopamine, epinephrine and norepinephrine into subcellular storage organelles in a variety of cells. Accumulation of the neurotransmitter depends on the proton electrochemical gradient across the organelle membrane and involves...

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Veröffentlicht in:	FEBS letters 1994-12, Vol.356 (1), p.145-150
Hauptverfasser:	Shirvan, Anat, Laskar, Orly, Steiner-Mordoch, Sonia, Schuldiner, Shimon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiporter Arginine - metabolism Biological Transport CCCP, carbonyl cyanide m-chlorophenyl hydrazone Cysteine - metabolism DEPC, diethyl pyrocarbonate Drug resistance Energy coupling Energy Metabolism Glycoproteins - genetics Glycoproteins - metabolism H + transport Histidine Histidine - metabolism Membrane Glycoproteins Membrane Transport Proteins Mutagenesis, Site-Directed Neuropeptides Neurotransmitter Agents - genetics Neurotransmitter Agents - metabolism Neurotransmitter transport PG, phenylglyoxal Rats Reserpine - metabolism Serotonin - metabolism TEXANS Vesicular Biogenic Amine Transport Proteins Vesicular Monoamine Transport Proteins VMAT, vesicular monoamine transporter ΔμH+, electrochemical potential for H
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