Dietary ethanol reduces phosphatidylcholine levels and inhibits the uptake of dietary choline in Drosophila melanogaster larvae
1. 1. Low to moderate concentrations of dietary ethanol (200 mM to 600 mM) significantly increased the level of phosphatidylethanolamine (PE), while phosphatidylcholine (PC) levels decreased in third instar larvae. This was seen in both ethanol tolerant and intolerant strains of Drosophila melanogas...
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| Veröffentlicht in: | Comparative biochemistry and physiology. A, Comparative physiology Comparative physiology, 1993, Vol.104 (4), p.837-844 |
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| container_title | Comparative biochemistry and physiology. A, Comparative physiology |
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| creator | Miller, Robert R Jonathan W, Yates Geer, Billy W |
| description | 1.
1. Low to moderate concentrations of dietary ethanol (200 mM to 600 mM) significantly increased the level of phosphatidylethanolamine (PE), while phosphatidylcholine (PC) levels decreased in third instar larvae. This was seen in both ethanol tolerant and intolerant strains of
Drosophila melanogaster, indicating that the reduction of PC is not associated with a high level of ethanol tolerance.
2.
2. The phospholipid changes were not ethanol-specific. Larvae fed ethanol,
n-butanol, isopropanol, methanol, and
n-propanol exhibited similar changes.
3.
3. At 200 mM concentrations, dietary ethanol acted as a competitive inhibitor for the larval uptake of dietary choline. At higher concentrations, dietary ethanol acted as a noncompetitive inhibitor. This ethanol-induced inhibition of dietary choline uptake can only partially explain the ethanol-induced reductions in larval PC. |
| doi_str_mv | 10.1016/0300-9629(93)90163-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_16717560</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>030096299390163X</els_id><sourcerecordid>16717560</sourcerecordid><originalsourceid>FETCH-LOGICAL-c410t-dedda823941e84f592fc0f3b4fdf9cbb47460dda424a90ddf7aa9bd0b48127483</originalsourceid><addsrcrecordid>eNp9kU9v1DAQxX0AlVL4BiB8QKgcAnbiTeILEmrLH6kSB6jUmzWxx43BG6e2s1JPfHW8bNgjJ1vzfvM8fkPIC87eccbb96xhrJJtLc9l81aWSlPdPiKnx_IT8jSln4wx3vDNCTnpmeykZKfk96XDDPGBYh5hCp5GNIvGROcxpHmE7MyD12PwbkLqcYc-UZgMddPoBpcTzSPSZc7wC2mw1Kxu_zrcRC9jSGEenQe6RV_euIOUMVIPcQf4jDy24BM-X88zcvPp6sfFl-r62-evFx-vKy04y5VBY6CvGyk49sJuZG01s80grLFSD4PoRMsKImoBslxsByAHwwbR87oTfXNG3hx85xjuF0xZbV3S6MtAGJakeNvxbtOyAooDqMvcKaJVc3Tb8ifFmdpnrfahqn2oSjbqb9bqtrS9XP2XYYvm2LQGXfTXqw5Jg7cRJu3SERNtx3gnC_bqgFkICu5iQW6-12VrRe15U--NPhyIsgncOYwqaYeTRuMi6qxMcP-f9A_AdqnO</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16717560</pqid></control><display><type>article</type><title>Dietary ethanol reduces phosphatidylcholine levels and inhibits the uptake of dietary choline in Drosophila melanogaster larvae</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Miller, Robert R ; Jonathan W, Yates ; Geer, Billy W</creator><creatorcontrib>Miller, Robert R ; Jonathan W, Yates ; Geer, Billy W</creatorcontrib><description>1.
1. Low to moderate concentrations of dietary ethanol (200 mM to 600 mM) significantly increased the level of phosphatidylethanolamine (PE), while phosphatidylcholine (PC) levels decreased in third instar larvae. This was seen in both ethanol tolerant and intolerant strains of
Drosophila melanogaster, indicating that the reduction of PC is not associated with a high level of ethanol tolerance.
2.
2. The phospholipid changes were not ethanol-specific. Larvae fed ethanol,
n-butanol, isopropanol, methanol, and
n-propanol exhibited similar changes.
3.
3. At 200 mM concentrations, dietary ethanol acted as a competitive inhibitor for the larval uptake of dietary choline. At higher concentrations, dietary ethanol acted as a noncompetitive inhibitor. This ethanol-induced inhibition of dietary choline uptake can only partially explain the ethanol-induced reductions in larval PC.</description><identifier>ISSN: 0300-9629</identifier><identifier>DOI: 10.1016/0300-9629(93)90163-X</identifier><identifier>PMID: 8097990</identifier><identifier>CODEN: CBPAB5</identifier><language>eng</language><publisher>New York, NY: Elsevier B.V</publisher><subject>Alcohols - pharmacology ; Animals ; Biochemistry. Physiology. Immunology ; Biological and medical sciences ; choline ; Choline - metabolism ; competitive inhibitors ; Diet ; Drosophila melanogaster ; Drosophila melanogaster - metabolism ; ethanol ; Ethanol - pharmacokinetics ; Ethanol - pharmacology ; Fundamental and applied biological sciences. Psychology ; inhibition ; inhibitors ; Insecta ; Invertebrates ; Larva - metabolism ; larvae ; noncompetitive inhibitors ; nutrient uptake ; phosphatidylcholines ; Phosphatidylcholines - metabolism ; phosphatidylethanolamines ; Phosphatidylethanolamines - metabolism ; Physiology. Development ; strain differences ; tolerance ; toxicity ; uptake mechanisms</subject><ispartof>Comparative biochemistry and physiology. A, Comparative physiology, 1993, Vol.104 (4), p.837-844</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-dedda823941e84f592fc0f3b4fdf9cbb47460dda424a90ddf7aa9bd0b48127483</citedby><cites>FETCH-LOGICAL-c410t-dedda823941e84f592fc0f3b4fdf9cbb47460dda424a90ddf7aa9bd0b48127483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4023,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4670179$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8097990$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miller, Robert R</creatorcontrib><creatorcontrib>Jonathan W, Yates</creatorcontrib><creatorcontrib>Geer, Billy W</creatorcontrib><title>Dietary ethanol reduces phosphatidylcholine levels and inhibits the uptake of dietary choline in Drosophila melanogaster larvae</title><title>Comparative biochemistry and physiology. A, Comparative physiology</title><addtitle>Comp Biochem Physiol Comp Physiol</addtitle><description>1.
1. Low to moderate concentrations of dietary ethanol (200 mM to 600 mM) significantly increased the level of phosphatidylethanolamine (PE), while phosphatidylcholine (PC) levels decreased in third instar larvae. This was seen in both ethanol tolerant and intolerant strains of
Drosophila melanogaster, indicating that the reduction of PC is not associated with a high level of ethanol tolerance.
2.
2. The phospholipid changes were not ethanol-specific. Larvae fed ethanol,
n-butanol, isopropanol, methanol, and
n-propanol exhibited similar changes.
3.
3. At 200 mM concentrations, dietary ethanol acted as a competitive inhibitor for the larval uptake of dietary choline. At higher concentrations, dietary ethanol acted as a noncompetitive inhibitor. This ethanol-induced inhibition of dietary choline uptake can only partially explain the ethanol-induced reductions in larval PC.</description><subject>Alcohols - pharmacology</subject><subject>Animals</subject><subject>Biochemistry. Physiology. Immunology</subject><subject>Biological and medical sciences</subject><subject>choline</subject><subject>Choline - metabolism</subject><subject>competitive inhibitors</subject><subject>Diet</subject><subject>Drosophila melanogaster</subject><subject>Drosophila melanogaster - metabolism</subject><subject>ethanol</subject><subject>Ethanol - pharmacokinetics</subject><subject>Ethanol - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>inhibition</subject><subject>inhibitors</subject><subject>Insecta</subject><subject>Invertebrates</subject><subject>Larva - metabolism</subject><subject>larvae</subject><subject>noncompetitive inhibitors</subject><subject>nutrient uptake</subject><subject>phosphatidylcholines</subject><subject>Phosphatidylcholines - metabolism</subject><subject>phosphatidylethanolamines</subject><subject>Phosphatidylethanolamines - metabolism</subject><subject>Physiology. Development</subject><subject>strain differences</subject><subject>tolerance</subject><subject>toxicity</subject><subject>uptake mechanisms</subject><issn>0300-9629</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9v1DAQxX0AlVL4BiB8QKgcAnbiTeILEmrLH6kSB6jUmzWxx43BG6e2s1JPfHW8bNgjJ1vzfvM8fkPIC87eccbb96xhrJJtLc9l81aWSlPdPiKnx_IT8jSln4wx3vDNCTnpmeykZKfk96XDDPGBYh5hCp5GNIvGROcxpHmE7MyD12PwbkLqcYc-UZgMddPoBpcTzSPSZc7wC2mw1Kxu_zrcRC9jSGEenQe6RV_euIOUMVIPcQf4jDy24BM-X88zcvPp6sfFl-r62-evFx-vKy04y5VBY6CvGyk49sJuZG01s80grLFSD4PoRMsKImoBslxsByAHwwbR87oTfXNG3hx85xjuF0xZbV3S6MtAGJakeNvxbtOyAooDqMvcKaJVc3Tb8ifFmdpnrfahqn2oSjbqb9bqtrS9XP2XYYvm2LQGXfTXqw5Jg7cRJu3SERNtx3gnC_bqgFkICu5iQW6-12VrRe15U--NPhyIsgncOYwqaYeTRuMi6qxMcP-f9A_AdqnO</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Miller, Robert R</creator><creator>Jonathan W, Yates</creator><creator>Geer, Billy W</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>1993</creationdate><title>Dietary ethanol reduces phosphatidylcholine levels and inhibits the uptake of dietary choline in Drosophila melanogaster larvae</title><author>Miller, Robert R ; Jonathan W, Yates ; Geer, Billy W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-dedda823941e84f592fc0f3b4fdf9cbb47460dda424a90ddf7aa9bd0b48127483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Alcohols - pharmacology</topic><topic>Animals</topic><topic>Biochemistry. Physiology. Immunology</topic><topic>Biological and medical sciences</topic><topic>choline</topic><topic>Choline - metabolism</topic><topic>competitive inhibitors</topic><topic>Diet</topic><topic>Drosophila melanogaster</topic><topic>Drosophila melanogaster - metabolism</topic><topic>ethanol</topic><topic>Ethanol - pharmacokinetics</topic><topic>Ethanol - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>inhibition</topic><topic>inhibitors</topic><topic>Insecta</topic><topic>Invertebrates</topic><topic>Larva - metabolism</topic><topic>larvae</topic><topic>noncompetitive inhibitors</topic><topic>nutrient uptake</topic><topic>phosphatidylcholines</topic><topic>Phosphatidylcholines - metabolism</topic><topic>phosphatidylethanolamines</topic><topic>Phosphatidylethanolamines - metabolism</topic><topic>Physiology. Development</topic><topic>strain differences</topic><topic>tolerance</topic><topic>toxicity</topic><topic>uptake mechanisms</topic><toplevel>online_resources</toplevel><creatorcontrib>Miller, Robert R</creatorcontrib><creatorcontrib>Jonathan W, Yates</creatorcontrib><creatorcontrib>Geer, Billy W</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Comparative biochemistry and physiology. A, Comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miller, Robert R</au><au>Jonathan W, Yates</au><au>Geer, Billy W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary ethanol reduces phosphatidylcholine levels and inhibits the uptake of dietary choline in Drosophila melanogaster larvae</atitle><jtitle>Comparative biochemistry and physiology. A, Comparative physiology</jtitle><addtitle>Comp Biochem Physiol Comp Physiol</addtitle><date>1993</date><risdate>1993</risdate><volume>104</volume><issue>4</issue><spage>837</spage><epage>844</epage><pages>837-844</pages><issn>0300-9629</issn><coden>CBPAB5</coden><abstract>1.
1. Low to moderate concentrations of dietary ethanol (200 mM to 600 mM) significantly increased the level of phosphatidylethanolamine (PE), while phosphatidylcholine (PC) levels decreased in third instar larvae. This was seen in both ethanol tolerant and intolerant strains of
Drosophila melanogaster, indicating that the reduction of PC is not associated with a high level of ethanol tolerance.
2.
2. The phospholipid changes were not ethanol-specific. Larvae fed ethanol,
n-butanol, isopropanol, methanol, and
n-propanol exhibited similar changes.
3.
3. At 200 mM concentrations, dietary ethanol acted as a competitive inhibitor for the larval uptake of dietary choline. At higher concentrations, dietary ethanol acted as a noncompetitive inhibitor. This ethanol-induced inhibition of dietary choline uptake can only partially explain the ethanol-induced reductions in larval PC.</abstract><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>8097990</pmid><doi>10.1016/0300-9629(93)90163-X</doi><tpages>8</tpages></addata></record> |
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| ispartof | Comparative biochemistry and physiology. A, Comparative physiology, 1993, Vol.104 (4), p.837-844 |
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| subjects | Alcohols - pharmacology Animals Biochemistry. Physiology. Immunology Biological and medical sciences choline Choline - metabolism competitive inhibitors Diet Drosophila melanogaster Drosophila melanogaster - metabolism ethanol Ethanol - pharmacokinetics Ethanol - pharmacology Fundamental and applied biological sciences. Psychology inhibition inhibitors Insecta Invertebrates Larva - metabolism larvae noncompetitive inhibitors nutrient uptake phosphatidylcholines Phosphatidylcholines - metabolism phosphatidylethanolamines Phosphatidylethanolamines - metabolism Physiology. Development strain differences tolerance toxicity uptake mechanisms |
| title | Dietary ethanol reduces phosphatidylcholine levels and inhibits the uptake of dietary choline in Drosophila melanogaster larvae |
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